DUSP2 — 61 ClinVar variants
All ClinVar germline DUSP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
1 Benign · 1 Likely benign · 59 Uncertain significance
Full DUSP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP2 p.Ala107Val Uncertain significance Single submitter
- DUSP2 p.Ala265Val Uncertain significance Single submitter
- DUSP2 p.Arg263Cys Uncertain significance Single submitter
- DUSP2 p.Arg26Ser Uncertain significance Single submitter
- DUSP2 p.Arg276Cys Uncertain significance Single submitter
- DUSP2 p.Arg33Gly Uncertain significance Single submitter
- DUSP2 p.Arg47Leu Uncertain significance Single submitter
- DUSP2 p.Arg57His Uncertain significance Single submitter
- DUSP2 p.Asn248Asp Uncertain significance Single submitter
- DUSP2 p.Asn248Thr Uncertain significance Single submitter
- DUSP2 p.Asp156Glu Uncertain significance Single submitter
- DUSP2 p.Asp31Ala Uncertain significance Single submitter
- DUSP2 p.Asp31Asn Uncertain significance Single submitter
- DUSP2 p.Glu231Lys Uncertain significance Single submitter
- DUSP2 p.Gly131Val Uncertain significance Single submitter
- DUSP2 p.Gly260Ser Uncertain significance Single submitter
- DUSP2 p.His42Gln Uncertain significance Single submitter
- DUSP2 p.Leu54Pro Uncertain significance Single submitter
- DUSP2 p.Leu54Val Uncertain significance Single submitter
- DUSP2 p.Pro152Leu Uncertain significance Single submitter
- DUSP2 p.Pro48Ala Uncertain significance Single submitter
- DUSP2 p.Ser188Leu Uncertain significance Single submitter
- DUSP2 p.Ser188Trp Uncertain significance Single submitter
- DUSP2 p.Ser97Ala Uncertain significance Single submitter
- DUSP2 p.Trp245Cys Uncertain significance Single submitter
- DUSP2 p.Val205Met Uncertain significance Single submitter
- DUSP2 p.Val43Leu Uncertain significance Single submitter
- DUSP2 p.Val90Gly Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- DUSP2 p.Ala265Pro Uncertain significance Single submitter
- DUSP2 p.Ala45Val Uncertain significance Single submitter
- DUSP2 p.Ala65Gly Uncertain significance Single submitter
- DUSP2 p.Arg26His Uncertain significance Single submitter
- DUSP2 p.Arg47Pro Uncertain significance Single submitter
- DUSP2 p.Arg56Leu Uncertain significance Single submitter
- DUSP2 p.Arg74His Uncertain significance Single submitter
- DUSP2 p.Arg82Cys Uncertain significance Single submitter
- DUSP2 p.Arg82His Uncertain significance Single submitter
- DUSP2 p.Arg87Trp Uncertain significance Single submitter
- DUSP2 p.Asp133Asn Uncertain significance Single submitter
- DUSP2 p.Asp73His Uncertain significance Single submitter
- DUSP2 p.Glu10Gln Uncertain significance Single submitter
- DUSP2 p.Glu23Asp Uncertain significance Single submitter
- DUSP2 p.Glu4Val Uncertain significance Single submitter
- DUSP2 p.Glu8Gly Uncertain significance Single submitter
- DUSP2 p.Gly292Glu Uncertain significance Single submitter
- DUSP2 p.Gly61Asp Uncertain significance Single submitter
- DUSP2 p.His108Asp Uncertain significance Single submitter
- DUSP2 p.Leu29Met Uncertain significance Single submitter
- DUSP2 p.Leu67Phe Uncertain significance Single submitter
- DUSP2 p.Pro103Ser Uncertain significance Single submitter
- DUSP2 p.Pro122Ser Uncertain significance Single submitter
- DUSP2 p.Pro147Arg Uncertain significance Single submitter
- DUSP2 p.Pro210Ala Uncertain significance Single submitter
- DUSP2 p.Ser105Arg Uncertain significance Single submitter
- DUSP2 p.Ser105Cys Uncertain significance Single submitter
- DUSP2 p.Val246Glu Uncertain significance Single submitter
- DUSP2 p.Val287Ile Uncertain significance Single submitter
- DUSP2 p.Val293Phe Uncertain significance Single submitter
- DUSP2 p.Val89Met Uncertain significance Single submitter
All DUSP2 variants
Benign 1
- p.Ser161= Single submitter
Likely benign 1
- p.Thr309= Single submitter
Uncertain significance 59
- p.Ala107Val Single submitter ⚠
- p.Ala265Pro Single submitter ⚠
- p.Ala265Val Single submitter ⚠
- p.Ala45Val Single submitter ⚠
- p.Ala65Gly Single submitter ⚠
- p.Arg263Cys Single submitter ⚠
- p.Arg26His Single submitter ⚠
- p.Arg26Ser Single submitter ⚠
- p.Arg276Cys Single submitter ⚠
- p.Arg33Gly Single submitter ⚠
- p.Arg47Leu Single submitter ⚠
- p.Arg47Pro Single submitter ⚠
- p.Arg56Leu Single submitter ⚠
- p.Arg57His Single submitter ⚠
- p.Arg74His Single submitter ⚠
- p.Arg82Cys Single submitter ⚠
- p.Arg82His Single submitter ⚠
- p.Arg87Trp Single submitter ⚠
- p.Asn248Asp Single submitter ⚠
- p.Asn248Thr Single submitter ⚠
- p.Asp133Asn Single submitter ⚠
- p.Asp156Glu Single submitter ⚠
- p.Asp31Ala Single submitter ⚠
- p.Asp31Asn Single submitter ⚠
- p.Asp73His Single submitter ⚠
- p.Glu10Gln Single submitter ⚠
- p.Glu231Lys Single submitter ⚠
- p.Glu23Asp Single submitter ⚠
- p.Glu4Val Single submitter ⚠
- p.Glu8Gly Single submitter ⚠
- p.Gly131Val Single submitter ⚠
- p.Gly260Ser Single submitter ⚠
- p.Gly292Glu Single submitter ⚠
- p.Gly61Asp Single submitter ⚠
- p.His108Asp Single submitter ⚠
- p.His42Gln Single submitter ⚠
- p.Leu29Met Single submitter ⚠
- p.Leu54Pro Single submitter ⚠
- p.Leu54Val Single submitter ⚠
- p.Leu67Phe Single submitter ⚠
- p.Pro103Ser Single submitter ⚠
- p.Pro122Ser Single submitter ⚠
- p.Pro147Arg Single submitter ⚠
- p.Pro152Leu Single submitter ⚠
- p.Pro210Ala Single submitter ⚠
- p.Pro48Ala Single submitter ⚠
- p.Ser105Arg Single submitter ⚠
- p.Ser105Cys Single submitter ⚠
- p.Ser188Leu Single submitter ⚠
- p.Ser188Trp Single submitter ⚠
- p.Ser97Ala Single submitter ⚠
- p.Trp245Cys Single submitter ⚠
- p.Val205Met Single submitter ⚠
- p.Val246Glu Single submitter ⚠
- p.Val287Ile Single submitter ⚠
- p.Val293Phe Single submitter ⚠
- p.Val43Leu Single submitter ⚠
- p.Val89Met Single submitter ⚠
- p.Val90Gly Single submitter ⚠