DUSP21 — 19 ClinVar variants
All ClinVar germline DUSP21 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
4 Likely benign · 15 Uncertain significance
Full DUSP21 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP21 p.Ala132Thr Uncertain significance Single submitter
- DUSP21 p.Ala5Thr Uncertain significance Single submitter
- DUSP21 p.Arg140His Uncertain significance Single submitter
- DUSP21 p.Asp75Asn Uncertain significance Single submitter
- DUSP21 p.Gln152Arg Uncertain significance Single submitter
- DUSP21 p.Gln15His Uncertain significance Single submitter
- DUSP21 p.Gly13Ser Uncertain significance Single submitter
- DUSP21 p.Gly174Val Uncertain significance Single submitter
- DUSP21 p.Ile25Thr Uncertain significance Single submitter
- DUSP21 p.Leu104Pro Uncertain significance Single submitter
- DUSP21 p.Leu42Phe Uncertain significance Single submitter
- DUSP21 p.Met127Lys Uncertain significance Single submitter
- DUSP21 p.Met190Thr Uncertain significance Single submitter
- DUSP21 p.Val56Ala Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All DUSP21 variants
Likely benign 4
- p.Arg139Cys Single submitter
- p.Leu184Val Single submitter
- p.Met107Val Single submitter
- p.Tyr82Cys Single submitter
Uncertain significance 15
- p.Ala132Thr Single submitter ⚠
- p.Ala5Thr Single submitter ⚠
- p.Arg140His Single submitter ⚠
- p.Asp178Gly Single submitter ⚠
- p.Asp75Asn Single submitter ⚠
- p.Gln152Arg Single submitter ⚠
- p.Gln15His Single submitter ⚠
- p.Gly13Ser Single submitter ⚠
- p.Gly174Val Single submitter ⚠
- p.Ile25Thr Single submitter ⚠
- p.Leu104Pro Single submitter ⚠
- p.Leu42Phe Single submitter ⚠
- p.Met127Lys Single submitter ⚠
- p.Met190Thr Single submitter ⚠
- p.Val56Ala Single submitter ⚠