DUSP22 — 55 ClinVar variants
All ClinVar germline DUSP22 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
3 Benign · 20 Likely benign · 32 Uncertain significance
Full DUSP22 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP22 c.*1874C>G Uncertain significance Single submitter
- DUSP22 c.*1897G>A Uncertain significance Single submitter
- DUSP22 c.*1898C>A Uncertain significance Single submitter
- DUSP22 c.*1898C>T Uncertain significance Single submitter
- DUSP22 c.*1903C>T Uncertain significance Single submitter
- DUSP22 c.*1913T>A Uncertain significance Single submitter
- DUSP22 p.Asn16His Uncertain significance Single submitter
- DUSP22 p.Gln145Arg Uncertain significance Single submitter
- DUSP22 p.Gly130Arg Uncertain significance Single submitter
- DUSP22 p.Gly15Asp Uncertain significance Single submitter
- DUSP22 p.His38Arg Uncertain significance Single submitter
- DUSP22 p.His87Arg Uncertain significance Single submitter
- DUSP22 p.Lys28Arg Uncertain significance Single submitter
- DUSP22 p.Met104Thr Uncertain significance Single submitter
- DUSP22 p.Ser157Asn Uncertain significance Single submitter
- DUSP22 p.Ser93Pro Uncertain significance Single submitter
- DUSP22 p.Val118Met Uncertain significance Single submitter
- DUSP22 p.Val129Met Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- DUSP22 c.*1877C>T Uncertain significance Single submitter
- DUSP22 c.*1891T>C Uncertain significance Single submitter
- DUSP22 p.Asn3Ser Uncertain significance Single submitter
- DUSP22 p.Asp108Gly Uncertain significance Single submitter
- DUSP22 p.Asp113Gly Uncertain significance Single submitter
- DUSP22 p.Glu137Lys Uncertain significance Single submitter
- DUSP22 p.Gly81Ser Uncertain significance Single submitter
- DUSP22 p.Ile100Met Uncertain significance Single submitter
- DUSP22 p.Lys151Asn Uncertain significance Single submitter
- DUSP22 p.Lys7Gln Uncertain significance Single submitter
- DUSP22 p.Lys7Glu Uncertain significance Single submitter
- DUSP22 p.Pro43Ser Uncertain significance Single submitter
- DUSP22 p.Tyr146Cys Uncertain significance Single submitter
- DUSP22 p.Val48Ala Uncertain significance Single submitter
-
DUSP22 p.Leu159Phe
Likely benign
No assertion criteria
DUSP22-related disorder
-
DUSP22 p.Val106Ile
Likely benign
No assertion criteria
DUSP22-related disorder
-
DUSP22 p.Val143Ile
Likely benign
No assertion criteria
DUSP22-related disorder
All DUSP22 variants
Benign 3
- c.264-7C>T Single submitter
- c.*1878G>A No assertion criteria DUSP22-related disorder
- p.Pro191= No assertion criteria DUSP22-related disorder
Likely benign 20
- p.Asn128= Single submitter
- p.Val129Leu Single submitter
- c.189-4C>T No assertion criteria DUSP22-related disorder
- c.56-6dup No assertion criteria DUSP22-related disorder
- c.-5C>T No assertion criteria DUSP22-related disorder
- c.*1871C>G No assertion criteria DUSP22-related disorder
- c.*2G>A No assertion criteria DUSP22-related disorder
- c.*8G>A No assertion criteria DUSP22-related disorder
- p.Ala23= No assertion criteria DUSP22-related disorder
- p.Ala56= No assertion criteria DUSP22-related disorder
- p.His75= No assertion criteria DUSP22-related disorder
- p.Leu159Phe No assertion criteria DUSP22-related disorder ⚠
- p.Leu51= No assertion criteria DUSP22-related disorder
- p.Pro195Leu No assertion criteria DUSP22-related disorder
- p.Ser95= No assertion criteria DUSP22-related disorder
- p.Thr105= No assertion criteria DUSP22-related disorder
- p.Thr202= No assertion criteria DUSP22-related disorder
- p.Tyr198= No assertion criteria DUSP22-related disorder
- p.Val106Ile No assertion criteria DUSP22-related disorder ⚠
- p.Val143Ile No assertion criteria DUSP22-related disorder ⚠
Uncertain significance 32
- c.*1874C>G Single submitter ⚠
- c.*1877C>T Single submitter ⚠
- c.*1891T>C Single submitter ⚠
- c.*1897G>A Single submitter ⚠
- c.*1898C>A Single submitter ⚠
- c.*1898C>T Single submitter ⚠
- c.*1903C>T Single submitter ⚠
- c.*1913T>A Single submitter ⚠
- p.Asn16His Single submitter ⚠
- p.Asn3Ser Single submitter ⚠
- p.Asp108Gly Single submitter ⚠
- p.Asp113Gly Single submitter ⚠
- p.Gln145Arg Single submitter ⚠
- p.Glu137Lys Single submitter ⚠
- p.Gly130Arg Single submitter ⚠
- p.Gly15Asp Single submitter ⚠
- p.Gly81Ser Single submitter ⚠
- p.His38Arg Single submitter ⚠
- p.His87Arg Single submitter ⚠
- p.Ile100Met Single submitter ⚠
- p.Lys151Asn Single submitter ⚠
- p.Lys28Arg Single submitter ⚠
- p.Lys7Gln Single submitter ⚠
- p.Lys7Glu Single submitter ⚠
- p.Met104Thr Single submitter ⚠
- p.Pro43Ser Single submitter ⚠
- p.Ser157Asn Single submitter ⚠
- p.Ser93Pro Single submitter ⚠
- p.Tyr146Cys Single submitter ⚠
- p.Val118Met Single submitter ⚠
- p.Val129Met Single submitter ⚠
- p.Val48Ala Single submitter ⚠