DUSP26 — 23 ClinVar variants
All ClinVar germline DUSP26 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
1 Likely benign · 22 Uncertain significance
Full DUSP26 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP26 p.Ala9Ser Uncertain significance Single submitter
- DUSP26 p.Arg100Gln Uncertain significance Single submitter
- DUSP26 p.Arg139Trp Uncertain significance Single submitter
- DUSP26 p.Arg16Cys Uncertain significance Single submitter
- DUSP26 p.Arg16His Uncertain significance Single submitter
- DUSP26 p.Arg19Gln Uncertain significance Single submitter
- DUSP26 p.Arg19Trp Uncertain significance Single submitter
- DUSP26 p.Arg81Trp Uncertain significance Single submitter
- DUSP26 p.Arg85Cys Uncertain significance Single submitter
- DUSP26 p.Asp135Asn Uncertain significance Single submitter
- DUSP26 p.Asp73Tyr Uncertain significance Single submitter
- DUSP26 p.Gly193Asp Uncertain significance Single submitter
- DUSP26 p.His151Arg Uncertain significance Single submitter
- DUSP26 p.Leu141Arg Uncertain significance Single submitter
- DUSP26 p.Met76Val Uncertain significance Single submitter
- DUSP26 p.Ser18Ala Uncertain significance Single submitter
- DUSP26 p.Ser22Leu Uncertain significance Single submitter
- DUSP26 p.Thr102Met Uncertain significance Single submitter
- DUSP26 p.Val176Met Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All DUSP26 variants
Likely benign 1
- p.Arg80His Single submitter
Uncertain significance 22
- p.Ala9Ser Single submitter ⚠
- p.Arg100Gln Single submitter ⚠
- p.Arg139Trp Single submitter ⚠
- p.Arg16Cys Single submitter ⚠
- p.Arg16His Single submitter ⚠
- p.Arg19Gln Single submitter ⚠
- p.Arg19Trp Single submitter ⚠
- p.Arg81Trp Single submitter ⚠
- p.Arg85Cys Single submitter ⚠
- p.Arg98Trp Single submitter
- p.Asp135Asn Single submitter ⚠
- p.Asp73Tyr Single submitter ⚠
- p.Cys59Tyr Single submitter ⚠
- p.Glu47Lys Single submitter ⚠
- p.Gly193Asp Single submitter ⚠
- p.His151Arg Single submitter ⚠
- p.Leu141Arg Single submitter ⚠
- p.Met76Val Single submitter ⚠
- p.Ser18Ala Single submitter ⚠
- p.Ser22Leu Single submitter ⚠
- p.Thr102Met Single submitter ⚠
- p.Val176Met Single submitter ⚠