DUSP3 — 20 ClinVar variants
All ClinVar germline DUSP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
1 Likely benign · 19 Uncertain significance
Full DUSP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP3 p.Arg104Thr Uncertain significance Single submitter
- DUSP3 p.Arg158Cys Uncertain significance Single submitter
- DUSP3 p.Asn74Ser Uncertain significance Single submitter
- DUSP3 p.Asp164Tyr Uncertain significance Single submitter
- DUSP3 p.Gln10Glu Uncertain significance Single submitter
- DUSP3 p.Gly19Ser Uncertain significance Single submitter
- DUSP3 p.His58Arg Uncertain significance Single submitter
- DUSP3 p.Lys50Arg Uncertain significance Single submitter
- DUSP3 p.Pro162Arg Uncertain significance Single submitter
- DUSP3 p.Thr133Met Uncertain significance Single submitter
- DUSP3 p.Val122Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DUSP3 p.Arg119Gln Uncertain significance Single submitter
- DUSP3 p.Arg125Trp Uncertain significance Single submitter
- DUSP3 p.Asn174Ser Uncertain significance Single submitter
- DUSP3 p.Glu103Lys Uncertain significance Single submitter
- DUSP3 p.Glu180Lys Uncertain significance Single submitter
- DUSP3 p.Gly82Ser Uncertain significance Single submitter
- DUSP3 p.Ile109Val Uncertain significance Single submitter
- DUSP3 p.Phe5Leu Uncertain significance Single submitter
All DUSP3 variants
Likely benign 1
- p.Asn61= Single submitter
Uncertain significance 19
- p.Arg104Thr Single submitter ⚠
- p.Arg119Gln Single submitter ⚠
- p.Arg125Trp Single submitter ⚠
- p.Arg158Cys Single submitter ⚠
- p.Asn174Ser Single submitter ⚠
- p.Asn74Ser Single submitter ⚠
- p.Asp164Tyr Single submitter ⚠
- p.Gln10Glu Single submitter ⚠
- p.Glu103Lys Single submitter ⚠
- p.Glu180Lys Single submitter ⚠
- p.Gly19Ser Single submitter ⚠
- p.Gly82Ser Single submitter ⚠
- p.His58Arg Single submitter ⚠
- p.Ile109Val Single submitter ⚠
- p.Lys50Arg Single submitter ⚠
- p.Phe5Leu Single submitter ⚠
- p.Pro162Arg Single submitter ⚠
- p.Thr133Met Single submitter ⚠
- p.Val122Ile Single submitter ⚠