DUSP4 — 52 ClinVar variants
All ClinVar germline DUSP4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
5 Likely benign · 47 Uncertain significance
Full DUSP4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP4 p.Ala163Gly Uncertain significance Single submitter
- DUSP4 p.Ala166Thr Uncertain significance Single submitter
- DUSP4 p.Ala212Ser Uncertain significance Single submitter
- DUSP4 p.Ala341Ser Uncertain significance Single submitter
- DUSP4 p.Arg213Gln Uncertain significance Single submitter
- DUSP4 p.Arg213Trp Uncertain significance Single submitter
- DUSP4 p.Arg273His Uncertain significance Single submitter
- DUSP4 p.Arg313His Uncertain significance Single submitter
- DUSP4 p.Glu116Asp Uncertain significance Single submitter
- DUSP4 p.Glu198Asp Uncertain significance Single submitter
- DUSP4 p.Glu23Lys Uncertain significance Single submitter
- DUSP4 p.Glu6Lys Uncertain significance Single submitter
- DUSP4 p.Glu91Ala Uncertain significance Single submitter
- DUSP4 p.Glu91Asp Uncertain significance Single submitter
- DUSP4 p.Gly274Arg Uncertain significance Single submitter
- DUSP4 p.His34Gln Uncertain significance Single submitter
- DUSP4 p.Ile199Met Uncertain significance Single submitter
- DUSP4 p.Leu37Pro Uncertain significance Single submitter
- DUSP4 p.Leu384Val Uncertain significance Single submitter
- DUSP4 p.Pro169Leu Uncertain significance Single submitter
- DUSP4 p.Pro169Ser Uncertain significance Single submitter
- DUSP4 p.Pro170Leu Uncertain significance Single submitter
- DUSP4 p.Pro170Ser Uncertain significance Single submitter
- DUSP4 p.Pro178Ala Uncertain significance Single submitter
- DUSP4 p.Pro189Ala Uncertain significance Single submitter
- DUSP4 p.Pro246Arg Uncertain significance Single submitter
- DUSP4 p.Pro392Ala Uncertain significance Single submitter
- DUSP4 p.Thr188Ala Uncertain significance Single submitter
- DUSP4 p.Thr223Lys Uncertain significance Single submitter
- DUSP4 p.Val107Leu Uncertain significance Single submitter
- DUSP4 p.Val269Ala Uncertain significance Single submitter
- DUSP4 p.Val276Met Uncertain significance Single submitter
- DUSP4 p.Val365Ile Uncertain significance Single submitter
- DUSP4 p.Val372Ala Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- DUSP4 p.Asp180Tyr Uncertain significance Single submitter
- DUSP4 p.Glu153Lys Uncertain significance Single submitter
- DUSP4 p.Glu156Gln Uncertain significance Single submitter
- DUSP4 p.Glu9Asp Uncertain significance Single submitter
- DUSP4 p.Gly38Val Uncertain significance Single submitter
- DUSP4 p.Ile106Leu Uncertain significance Single submitter
- DUSP4 p.Phe157Leu Uncertain significance Single submitter
- DUSP4 p.Ser379Arg Uncertain significance Single submitter
- DUSP4 p.Ser82Gly Uncertain significance Single submitter
- DUSP4 p.Thr337Met Uncertain significance Single submitter
- DUSP4 p.Val310Ile Uncertain significance Single submitter
- DUSP4 p.Val372Met Uncertain significance Single submitter
- DUSP4 p.Val374Met Uncertain significance Single submitter
All DUSP4 variants
Likely benign 5
- p.Ala175Thr Single submitter
- p.Ala282= Single submitter
- p.Ala341Val Single submitter
- p.Ala358Pro Single submitter
- p.His191= Single submitter
Uncertain significance 47
- p.Ala163Gly Single submitter ⚠
- p.Ala166Thr Single submitter ⚠
- p.Ala212Ser Single submitter ⚠
- p.Ala341Ser Single submitter ⚠
- p.Arg213Gln Single submitter ⚠
- p.Arg213Trp Single submitter ⚠
- p.Arg273His Single submitter ⚠
- p.Arg313His Single submitter ⚠
- p.Asp180Tyr Single submitter ⚠
- p.Glu116Asp Single submitter ⚠
- p.Glu153Lys Single submitter ⚠
- p.Glu156Gln Single submitter ⚠
- p.Glu198Asp Single submitter ⚠
- p.Glu23Lys Single submitter ⚠
- p.Glu6Lys Single submitter ⚠
- p.Glu91Ala Single submitter ⚠
- p.Glu91Asp Single submitter ⚠
- p.Glu9Asp Single submitter ⚠
- p.Gly274Arg Single submitter ⚠
- p.Gly38Val Single submitter ⚠
- p.His34Gln Single submitter ⚠
- p.Ile106Leu Single submitter ⚠
- p.Ile199Met Single submitter ⚠
- p.Leu37Pro Single submitter ⚠
- p.Leu384Val Single submitter ⚠
- p.Phe157Leu Single submitter ⚠
- p.Pro169Leu Single submitter ⚠
- p.Pro169Ser Single submitter ⚠
- p.Pro170Leu Single submitter ⚠
- p.Pro170Ser Single submitter ⚠
- p.Pro178Ala Single submitter ⚠
- p.Pro189Ala Single submitter ⚠
- p.Pro246Arg Single submitter ⚠
- p.Pro392Ala Single submitter ⚠
- p.Ser379Arg Single submitter ⚠
- p.Ser82Gly Single submitter ⚠
- p.Thr188Ala Single submitter ⚠
- p.Thr223Lys Single submitter ⚠
- p.Thr337Met Single submitter ⚠
- p.Val107Leu Single submitter ⚠
- p.Val269Ala Single submitter ⚠
- p.Val276Met Single submitter ⚠
- p.Val310Ile Single submitter ⚠
- p.Val365Ile Single submitter ⚠
- p.Val372Ala Single submitter ⚠
- p.Val372Met Single submitter ⚠
- p.Val374Met Single submitter ⚠