DUSP5 — 68 ClinVar variants
All ClinVar germline DUSP5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
2 Benign · 1 Likely benign · 65 Uncertain significance
Full DUSP5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP5 p.Asp291Asn Uncertain significance Multiple submitters
- DUSP5 p.Ala104Val Uncertain significance Single submitter
- DUSP5 p.Ala59Pro Uncertain significance Single submitter
- DUSP5 p.Arg121Leu Uncertain significance Single submitter
- DUSP5 p.Arg213Gln Uncertain significance Single submitter
- DUSP5 p.Arg269Cys Uncertain significance Single submitter
- DUSP5 p.Arg285His Uncertain significance Single submitter
- DUSP5 p.Arg40Cys Uncertain significance Single submitter
- DUSP5 p.Arg63Ser Uncertain significance Single submitter
- DUSP5 p.Arg74Leu Uncertain significance Single submitter
- DUSP5 p.Arg94Cys Uncertain significance Single submitter
- DUSP5 p.Asn38Tyr Uncertain significance Single submitter
- DUSP5 p.Asn46His Uncertain significance Single submitter
- DUSP5 p.Asp142Asn Uncertain significance Single submitter
- DUSP5 p.Asp68Glu Uncertain significance Single submitter
- DUSP5 p.Asp7Gly Uncertain significance Single submitter
- DUSP5 p.Cys197Trp Uncertain significance Single submitter
- DUSP5 p.Cys28Trp Uncertain significance Single submitter
- DUSP5 p.Gln148Arg Uncertain significance Single submitter
- DUSP5 p.Gln160Arg Uncertain significance Single submitter
- DUSP5 p.Glu130Gln Uncertain significance Single submitter
- DUSP5 p.Glu130Lys Uncertain significance Single submitter
- DUSP5 p.Glu18Asp Uncertain significance Single submitter
- DUSP5 p.Glu198Lys Uncertain significance Single submitter
- DUSP5 p.Glu314Lys Uncertain significance Single submitter
- DUSP5 p.Glu78Val Uncertain significance Single submitter
- DUSP5 p.Gly162Glu Uncertain significance Single submitter
- DUSP5 p.Gly351Arg Uncertain significance Single submitter
- DUSP5 p.Gly79Ser Uncertain significance Single submitter
- DUSP5 p.His193Tyr Uncertain significance Single submitter
- DUSP5 p.His341Tyr Uncertain significance Single submitter
- DUSP5 p.Ile246Val Uncertain significance Single submitter
- DUSP5 p.Ile273Leu Uncertain significance Single submitter
- DUSP5 p.Leu208Val Uncertain significance Single submitter
- DUSP5 p.Leu278Phe Uncertain significance Single submitter
- DUSP5 p.Leu47Phe Uncertain significance Single submitter
- DUSP5 p.Leu47Pro Uncertain significance Single submitter
- DUSP5 p.Met349Ile Uncertain significance Single submitter
- DUSP5 p.Phe290Ser Uncertain significance Single submitter
- DUSP5 p.Pro120Ser Uncertain significance Single submitter
- DUSP5 p.Pro164Arg Uncertain significance Single submitter
- DUSP5 p.Pro184Thr Uncertain significance Single submitter
- DUSP5 p.Pro30Ser Uncertain significance Single submitter
- DUSP5 p.Pro326Leu Uncertain significance Single submitter
- DUSP5 p.Pro363Leu Uncertain significance Single submitter
- DUSP5 p.Ser359Leu Uncertain significance Single submitter
- DUSP5 p.Ser368Leu Uncertain significance Single submitter
- DUSP5 p.Ser61Trp Uncertain significance Single submitter
- DUSP5 p.Thr110Ala Uncertain significance Single submitter
- DUSP5 p.Thr355Pro Uncertain significance Single submitter
- DUSP5 p.Thr380Arg Uncertain significance Single submitter
- DUSP5 p.Tyr123Cys Uncertain significance Single submitter
- DUSP5 p.Tyr133Cys Uncertain significance Single submitter
- DUSP5 p.Tyr64Cys Uncertain significance Single submitter
- DUSP5 p.Val141Leu Uncertain significance Single submitter
- DUSP5 p.Val141Met Uncertain significance Single submitter
- DUSP5 p.Val143Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- DUSP5 p.Arg16Ser Uncertain significance Single submitter
- DUSP5 p.Arg56Pro Uncertain significance Single submitter
- DUSP5 p.Lys13Glu Uncertain significance Single submitter
- DUSP5 p.Phe356Leu Uncertain significance Single submitter
- DUSP5 p.Ser5Leu Uncertain significance Single submitter
- DUSP5 p.Val88Ala Uncertain significance Single submitter
All DUSP5 variants
Benign 2
- p.Ala55Ser Multiple submitters
- p.Thr321= Single submitter
Likely benign 1
- p.Cys140= Single submitter
Uncertain significance 65
- p.Asp291Asn Multiple submitters ⚠
- p.Ala104Val Single submitter ⚠
- p.Ala59Pro Single submitter ⚠
- p.Arg121Leu Single submitter ⚠
- p.Arg16Ser Single submitter ⚠
- p.Arg213Gln Single submitter ⚠
- p.Arg269Cys Single submitter ⚠
- p.Arg285His Single submitter ⚠
- p.Arg40Cys Single submitter ⚠
- p.Arg56Pro Single submitter ⚠
- p.Arg63Ser Single submitter ⚠
- p.Arg74Leu Single submitter ⚠
- p.Arg94Cys Single submitter ⚠
- p.Asn38Tyr Single submitter ⚠
- p.Asn46His Single submitter ⚠
- p.Asp142Asn Single submitter ⚠
- p.Asp68Glu Single submitter ⚠
- p.Asp7Gly Single submitter ⚠
- p.Cys197Trp Single submitter ⚠
- p.Cys28Trp Single submitter ⚠
- p.Gln148Arg Single submitter ⚠
- p.Gln160Arg Single submitter ⚠
- p.Glu130Gln Single submitter ⚠
- p.Glu130Lys Single submitter ⚠
- p.Glu18Asp Single submitter ⚠
- p.Glu198Lys Single submitter ⚠
- p.Glu314Lys Single submitter ⚠
- p.Glu78Val Single submitter ⚠
- p.Gly162Glu Single submitter ⚠
- p.Gly351Arg Single submitter ⚠
- p.Gly79Ser Single submitter ⚠
- p.His193Tyr Single submitter ⚠
- p.His341Tyr Single submitter ⚠
- p.Ile246Val Single submitter ⚠
- p.Ile273Leu Single submitter ⚠
- p.Leu208Val Single submitter ⚠
- p.Leu278Phe Single submitter ⚠
- p.Leu47Phe Single submitter ⚠
- p.Leu47Pro Single submitter ⚠
- p.Lys13Glu Single submitter ⚠
- p.Met307Leu Single submitter
- p.Met349Ile Single submitter ⚠
- p.Phe290Ser Single submitter ⚠
- p.Phe356Leu Single submitter ⚠
- p.Pro120Ser Single submitter ⚠
- p.Pro164Arg Single submitter ⚠
- p.Pro184Thr Single submitter ⚠
- p.Pro30Ser Single submitter ⚠
- p.Pro326Leu Single submitter ⚠
- p.Pro363Leu Single submitter ⚠
- p.Ser359Leu Single submitter ⚠
- p.Ser368Leu Single submitter ⚠
- p.Ser5Leu Single submitter ⚠
- p.Ser61Trp Single submitter ⚠
- p.Thr110Ala Single submitter ⚠
- p.Thr355Pro Single submitter ⚠
- p.Thr380Arg Single submitter ⚠
- p.Tyr123Cys Single submitter ⚠
- p.Tyr133Cys Single submitter ⚠
- p.Tyr292Asp Single submitter
- p.Tyr64Cys Single submitter ⚠
- p.Val141Leu Single submitter ⚠
- p.Val141Met Single submitter ⚠
- p.Val143Ile Single submitter ⚠
- p.Val88Ala Single submitter ⚠