DUSP9 — 60 ClinVar variants
All ClinVar germline DUSP9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
3 Benign · 3 Likely benign · 54 Uncertain significance
Full DUSP9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP9 p.Ala226Ser Uncertain significance Single submitter
- DUSP9 p.Ala45Thr Uncertain significance Single submitter
- DUSP9 p.Ala48Thr Uncertain significance Single submitter
- DUSP9 p.Arg200Gln Uncertain significance Single submitter
- DUSP9 p.Arg231His Uncertain significance Single submitter
- DUSP9 p.Arg345Gln Uncertain significance Single submitter
- DUSP9 p.Asn247Ser Uncertain significance Single submitter
- DUSP9 p.Glu380Lys Uncertain significance Single submitter
- DUSP9 p.Gly147Ser Uncertain significance Single submitter
- DUSP9 p.Gly285Arg Uncertain significance Single submitter
- DUSP9 p.Gly358Ala Uncertain significance Single submitter
- DUSP9 p.Gly84Asp Uncertain significance Single submitter
- DUSP9 p.His136Gln Uncertain significance Single submitter
- DUSP9 p.Leu211Phe Uncertain significance Single submitter
- DUSP9 p.Lys227Glu Uncertain significance Single submitter
- DUSP9 p.Pro18Gln Uncertain significance Single submitter
- DUSP9 p.Pro256Leu Uncertain significance Single submitter
- DUSP9 p.Ser141Asn Uncertain significance Single submitter
- DUSP9 p.Ser224Asn Uncertain significance Single submitter
- DUSP9 p.Thr374Asn Uncertain significance Single submitter
- DUSP9 p.Val159Leu Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- DUSP9 p.Ala174Val Uncertain significance Single submitter
- DUSP9 p.Ala362Val Uncertain significance Single submitter
- DUSP9 p.Arg145His Uncertain significance Single submitter
- DUSP9 p.Arg200Trp Uncertain significance Single submitter
- DUSP9 p.Arg217Gln Uncertain significance Single submitter
- DUSP9 p.Arg342Cys Uncertain significance Single submitter
- DUSP9 p.Arg342His Uncertain significance Single submitter
- DUSP9 p.Arg342Leu Uncertain significance Single submitter
- DUSP9 p.Arg349Cys Uncertain significance Single submitter
- DUSP9 p.Arg56Gly Uncertain significance Single submitter
- DUSP9 p.Arg89Trp Uncertain significance Single submitter
- DUSP9 p.Arg90Cys Uncertain significance Single submitter
- DUSP9 p.Asp170Tyr Uncertain significance Single submitter
- DUSP9 p.Asp181Asn Uncertain significance Single submitter
- DUSP9 p.Cys284Trp Uncertain significance Single submitter
- DUSP9 p.Glu177Lys Uncertain significance Single submitter
- DUSP9 p.Glu94Ala Uncertain significance Single submitter
- DUSP9 p.Glu96Ala Uncertain significance Single submitter
- DUSP9 p.Gly86Cys Uncertain significance Single submitter
- DUSP9 p.Leu211Val Uncertain significance Single submitter
- DUSP9 p.Phe379Leu Uncertain significance Single submitter
- DUSP9 p.Pro17Ser Uncertain significance Single submitter
- DUSP9 p.Pro17Thr Uncertain significance Single submitter
- DUSP9 p.Pro18Leu Uncertain significance Single submitter
- DUSP9 p.Pro72Arg Uncertain significance Single submitter
- DUSP9 p.Pro74Ser Uncertain significance Single submitter
- DUSP9 p.Ser189Leu Uncertain significance Single submitter
- DUSP9 p.Ser281Phe Uncertain significance Single submitter
- DUSP9 p.Ser351Trp Uncertain significance Single submitter
- DUSP9 p.Ser364Phe Uncertain significance Single submitter
- DUSP9 p.Val236Ile Uncertain significance Single submitter
- DUSP9 p.Val78Met Uncertain significance Single submitter
- DUSP9 p.Pro152Leu Uncertain significance No assertion criteria
All DUSP9 variants
Benign 3
- p.Ala151Val Multiple submitters
- p.Ala174= Multiple submitters
- p.Pro158= Multiple submitters
Likely benign 3
- p.Ala120= Single submitter
- p.Ala362Thr Single submitter
- p.Gly377= Single submitter
Uncertain significance 54
- p.Ala174Val Single submitter ⚠
- p.Ala226Ser Single submitter ⚠
- p.Ala362Val Single submitter ⚠
- p.Ala45Thr Single submitter ⚠
- p.Ala48Thr Single submitter ⚠
- p.Arg145His Single submitter ⚠
- p.Arg200Gln Single submitter ⚠
- p.Arg200Trp Single submitter ⚠
- p.Arg217Gln Single submitter ⚠
- p.Arg231His Single submitter ⚠
- p.Arg342Cys Single submitter ⚠
- p.Arg342His Single submitter ⚠
- p.Arg342Leu Single submitter ⚠
- p.Arg345Gln Single submitter ⚠
- p.Arg349Cys Single submitter ⚠
- p.Arg56Gly Single submitter ⚠
- p.Arg89Trp Single submitter ⚠
- p.Arg90Cys Single submitter ⚠
- p.Asn247Ser Single submitter ⚠
- p.Asp170Tyr Single submitter ⚠
- p.Asp181Asn Single submitter ⚠
- p.Cys284Trp Single submitter ⚠
- p.Glu177Lys Single submitter ⚠
- p.Glu380Lys Single submitter ⚠
- p.Glu94Ala Single submitter ⚠
- p.Glu96Ala Single submitter ⚠
- p.Gly147Ser Single submitter ⚠
- p.Gly285Arg Single submitter ⚠
- p.Gly358Ala Single submitter ⚠
- p.Gly84Asp Single submitter ⚠
- p.Gly86Cys Single submitter ⚠
- p.His136Gln Single submitter ⚠
- p.Leu211Phe Single submitter ⚠
- p.Leu211Val Single submitter ⚠
- p.Lys227Glu Single submitter ⚠
- p.Phe379Leu Single submitter ⚠
- p.Pro17Ser Single submitter ⚠
- p.Pro17Thr Single submitter ⚠
- p.Pro18Gln Single submitter ⚠
- p.Pro18Leu Single submitter ⚠
- p.Pro256Leu Single submitter ⚠
- p.Pro72Arg Single submitter ⚠
- p.Pro74Ser Single submitter ⚠
- p.Ser141Asn Single submitter ⚠
- p.Ser189Leu Single submitter ⚠
- p.Ser224Asn Single submitter ⚠
- p.Ser281Phe Single submitter ⚠
- p.Ser351Trp Single submitter ⚠
- p.Ser364Phe Single submitter ⚠
- p.Thr374Asn Single submitter ⚠
- p.Val159Leu Single submitter ⚠
- p.Val236Ile Single submitter ⚠
- p.Val78Met Single submitter ⚠
- p.Pro152Leu No assertion criteria ⚠