DVL2 — 125 ClinVar variants
All ClinVar germline DVL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 101 flagged for review →
9 Benign · 11 Likely benign · 105 Uncertain significance
Full DVL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 101
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 68
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DVL2 p.Ala114Val Uncertain significance Single submitter
- DVL2 p.Ala611Ser Uncertain significance Single submitter
- DVL2 p.Arg163Gln Uncertain significance Single submitter
- DVL2 p.Arg231His Uncertain significance Single submitter
- DVL2 p.Arg235His Uncertain significance Single submitter
- DVL2 p.Arg289Gln Uncertain significance Single submitter
- DVL2 p.Arg310His Uncertain significance Single submitter
- DVL2 p.Arg415Trp Uncertain significance Single submitter
- DVL2 p.Arg472Trp Uncertain significance Single submitter
- DVL2 p.Arg476His Uncertain significance Single submitter
- DVL2 p.Arg590Gln Uncertain significance Single submitter
- DVL2 p.Arg590Pro Uncertain significance Single submitter
- DVL2 p.Arg603Cys Uncertain significance Single submitter
- DVL2 p.Arg603His Uncertain significance Single submitter
- DVL2 p.Arg610Gln Uncertain significance Single submitter
- DVL2 p.Arg627Gln Uncertain significance Single submitter
- DVL2 p.Arg633Gln Uncertain significance Single submitter
- DVL2 p.Asn451Asp Uncertain significance Single submitter
- DVL2 p.Asn727Ser Uncertain significance Single submitter
- DVL2 p.Asp212Glu Uncertain significance Single submitter
- DVL2 p.Asp410His Uncertain significance Single submitter
- DVL2 p.Asp706Glu Uncertain significance Single submitter
- DVL2 p.Cys354Tyr Uncertain significance Single submitter
- DVL2 p.Glu105Ala Uncertain significance Single submitter
- DVL2 p.Glu148Gln Uncertain significance Single submitter
- DVL2 p.Glu202Lys Uncertain significance Single submitter
- DVL2 p.Glu609Gly Uncertain significance Single submitter
- DVL2 p.Gly181Asp Uncertain significance Single submitter
- DVL2 p.Gly293Asp Uncertain significance Single submitter
- DVL2 p.Gly578Arg Uncertain significance Single submitter
- DVL2 p.Gly599Ala Uncertain significance Single submitter
- DVL2 p.Gly605Ala Uncertain significance Single submitter
- DVL2 p.Gly617Ser Uncertain significance Single submitter
- DVL2 p.Gly629Asp Uncertain significance Single submitter
- DVL2 p.Gly7Arg Uncertain significance Single submitter
- DVL2 p.His188Arg Uncertain significance Single submitter
- DVL2 p.His420Tyr Uncertain significance Single submitter
- DVL2 p.His569Tyr Uncertain significance Single submitter
- DVL2 p.Ile266Val Uncertain significance Single submitter
- DVL2 p.Ile294Met Uncertain significance Single submitter
- DVL2 p.Ile311Val Uncertain significance Single submitter
- DVL2 p.Ile340Val Uncertain significance Single submitter
- DVL2 p.Ile374Val Uncertain significance Single submitter
- DVL2 p.Leu208Val Uncertain significance Single submitter
- DVL2 p.Leu247Val Uncertain significance Single submitter
- DVL2 p.Leu519Val Uncertain significance Single submitter
- DVL2 p.Met199Val Uncertain significance Single submitter
- DVL2 p.Met323Leu Uncertain significance Single submitter
- DVL2 p.Met60Val Uncertain significance Single submitter
- DVL2 p.Pro101Ser Uncertain significance Single submitter
- DVL2 p.Pro118Ser Uncertain significance Single submitter
- DVL2 p.Pro119Leu Uncertain significance Single submitter
- DVL2 p.Pro366Leu Uncertain significance Single submitter
- DVL2 p.Pro656Ser Uncertain significance Single submitter
- DVL2 p.Pro670His Uncertain significance Single submitter
- DVL2 p.Pro690Ser Uncertain significance Single submitter
- DVL2 p.Pro699Leu Uncertain significance Single submitter
- DVL2 p.Pro97Ser Uncertain significance Single submitter
- DVL2 p.Ser170Gly Uncertain significance Single submitter
- DVL2 p.Ser5Ile Uncertain significance Single submitter
- DVL2 p.Thr125Ile Uncertain significance Single submitter
- DVL2 p.Thr575Ile Uncertain significance Single submitter
- DVL2 p.Tyr18Cys Uncertain significance Single submitter
- DVL2 p.Tyr553Phe Uncertain significance Single submitter
- DVL2 p.Tyr576Cys Uncertain significance Single submitter
- DVL2 p.Tyr667His Uncertain significance Single submitter
- DVL2 p.Val11Ala Uncertain significance Single submitter
- DVL2 p.Val504Ile Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- DVL2 p.Ala384Val Uncertain significance Single submitter
- DVL2 p.Ala385Thr Uncertain significance Single submitter
- DVL2 p.Arg161Trp Uncertain significance Single submitter
- DVL2 p.Arg335Gln Uncertain significance Single submitter
- DVL2 p.Arg335Gly Uncertain significance Single submitter
- DVL2 p.Arg367Gln Uncertain significance Single submitter
- DVL2 p.Arg632Trp Uncertain significance Single submitter
- DVL2 p.Arg718Cys Uncertain significance Single submitter
- DVL2 p.Asn264Asp Uncertain significance Single submitter
- DVL2 p.Asp339Asn Uncertain significance Single submitter
- DVL2 p.Glu36Gln Uncertain significance Single submitter
- DVL2 p.Gly529Glu Uncertain significance Single submitter
- DVL2 p.Gly617Asp Uncertain significance Single submitter
- DVL2 p.Ile128Thr Uncertain significance Single submitter
- DVL2 p.Ile282Val Uncertain significance Single submitter
- DVL2 p.Ile347Leu Uncertain significance Single submitter
- DVL2 p.Met736Leu Uncertain significance Single submitter
- DVL2 p.Phe721Leu Uncertain significance Single submitter
- DVL2 p.Pro433Thr Uncertain significance Single submitter
- DVL2 p.Pro712Gln Uncertain significance Single submitter
- DVL2 p.Ser400Asn Uncertain significance Single submitter
- DVL2 p.Ser527Cys Uncertain significance Single submitter
- DVL2 p.Ser626Asn Uncertain significance Single submitter
- DVL2 p.Ser729Arg Uncertain significance Single submitter
- DVL2 p.Ser87Thr Uncertain significance Single submitter
- DVL2 p.Thr216Ile Uncertain significance Single submitter
- DVL2 p.Thr269Met Uncertain significance Single submitter
- DVL2 p.Val380Leu Uncertain significance Single submitter
- DVL2 p.Val419Phe Uncertain significance Single submitter
- DVL2 p.Val466Met Uncertain significance Single submitter
- DVL2 p.Val90Leu Uncertain significance Single submitter
-
DVL2 p.Arg77His
Likely benign
No assertion criteria
DVL2-related disorder
-
DVL2 p.Thr535Ile
Benign
No assertion criteria
DVL2-related disorder
All DVL2 variants
Benign 9
- c.1035-8C>T Multiple submitters
- c.1544-16T>C Multiple submitters
- p.Gln554= Multiple submitters
- p.Leu317= Multiple submitters
- p.Ser207= Multiple submitters
- p.Arg415Gln Single submitter
- c.410+10T>C No assertion criteria DVL2-related disorder
- p.Ser135= No assertion criteria DVL2-related disorder
- p.Thr535Ile No assertion criteria DVL2-related disorder ⚠
Likely benign 11
- p.Thr250= Multiple submitters
- p.Ala53Val Single submitter
- p.Val419Ile Single submitter
- c.656+8T>G No assertion criteria DVL2-related disorder
- c.748-8C>T No assertion criteria DVL2-related disorder
- c.-4G>C No assertion criteria DVL2-related disorder
- p.Ala111Val No assertion criteria DVL2-related disorder
- p.Arg77His No assertion criteria DVL2-related disorder ⚠
- p.Glu193= No assertion criteria DVL2-related disorder
- p.Gly8= No assertion criteria DVL2-related disorder
- p.Ile71= No assertion criteria DVL2-related disorder
Uncertain significance 105
- p.Ala114Val Single submitter ⚠
- p.Ala384Val Single submitter ⚠
- p.Ala385Thr Single submitter ⚠
- p.Ala611Ser Single submitter ⚠
- p.Arg161Trp Single submitter ⚠
- p.Arg163Gln Single submitter ⚠
- p.Arg187Cys Single submitter
- p.Arg231His Single submitter ⚠
- p.Arg235His Single submitter ⚠
- p.Arg289Gln Single submitter ⚠
- p.Arg310His Single submitter ⚠
- p.Arg335Gln Single submitter ⚠
- p.Arg335Gly Single submitter ⚠
- p.Arg367Gln Single submitter ⚠
- p.Arg415Trp Single submitter ⚠
- p.Arg472Trp Single submitter ⚠
- p.Arg476His Single submitter ⚠
- p.Arg590Gln Single submitter ⚠
- p.Arg590Pro Single submitter ⚠
- p.Arg603Cys Single submitter ⚠
- p.Arg603His Single submitter ⚠
- p.Arg610Gln Single submitter ⚠
- p.Arg627Gln Single submitter ⚠
- p.Arg632Trp Single submitter ⚠
- p.Arg633Gln Single submitter ⚠
- p.Arg718Cys Single submitter ⚠
- p.Asn264Asp Single submitter ⚠
- p.Asn451Asp Single submitter ⚠
- p.Asn727Ser Single submitter ⚠
- p.Asp212Glu Single submitter ⚠
- p.Asp339Asn Single submitter ⚠
- p.Asp410His Single submitter ⚠
- p.Asp706Glu Single submitter ⚠
- p.Cys354Tyr Single submitter ⚠
- p.Glu105Ala Single submitter ⚠
- p.Glu148Gln Single submitter ⚠
- p.Glu202Lys Single submitter ⚠
- p.Glu36Gln Single submitter ⚠
- p.Glu609Gly Single submitter ⚠
- p.Gly181Asp Single submitter ⚠
- p.Gly293Asp Single submitter ⚠
- p.Gly529Glu Single submitter ⚠
- p.Gly578Arg Single submitter ⚠
- p.Gly599Ala Single submitter ⚠
- p.Gly605Ala Single submitter ⚠
- p.Gly617Asp Single submitter ⚠
- p.Gly617Ser Single submitter ⚠
- p.Gly629Asp Single submitter ⚠
- p.Gly7Arg Single submitter ⚠
- p.His188Arg Single submitter ⚠
- p.His420Tyr Single submitter ⚠
- p.His569Tyr Single submitter ⚠
- p.Ile128Thr Single submitter ⚠
- p.Ile266Val Single submitter ⚠
- p.Ile282Val Single submitter ⚠
- p.Ile294Met Single submitter ⚠
- p.Ile311Val Single submitter ⚠
- p.Ile340Val Single submitter ⚠
- p.Ile347Leu Single submitter ⚠
- p.Ile374Val Single submitter ⚠
- p.Leu208Val Single submitter ⚠
- p.Leu247Val Single submitter ⚠
- p.Leu519Val Single submitter ⚠
- p.Met199Val Single submitter ⚠
- p.Met323Leu Single submitter ⚠
- p.Met443Val Single submitter
- p.Met60Val Single submitter ⚠
- p.Met736Leu Single submitter ⚠
- p.Phe721Leu Single submitter ⚠
- p.Pro101Ser Single submitter ⚠
- p.Pro118Ser Single submitter ⚠
- p.Pro119Leu Single submitter ⚠
- p.Pro366Leu Single submitter ⚠
- p.Pro433Thr Single submitter ⚠
- p.Pro656Ser Single submitter ⚠
- p.Pro670His Single submitter ⚠
- p.Pro690Ser Single submitter ⚠
- p.Pro699Leu Single submitter ⚠
- p.Pro712Gln Single submitter ⚠
- p.Pro97Ser Single submitter ⚠
- p.Ser170Gly Single submitter ⚠
- p.Ser230Phe Single submitter
- p.Ser251Pro Single submitter
- p.Ser400Asn Single submitter ⚠
- p.Ser527Cys Single submitter ⚠
- p.Ser5Ile Single submitter ⚠
- p.Ser626Asn Single submitter ⚠
- p.Ser729Arg Single submitter ⚠
- p.Ser87Thr Single submitter ⚠
- p.Ser91Tyr Single submitter
- p.Thr125Ile Single submitter ⚠
- p.Thr216Ile Single submitter ⚠
- p.Thr269Arg Single submitter
- p.Thr269Met Single submitter ⚠
- p.Thr575Ile Single submitter ⚠
- p.Tyr18Cys Single submitter ⚠
- p.Tyr553Phe Single submitter ⚠
- p.Tyr576Cys Single submitter ⚠
- p.Tyr667His Single submitter ⚠
- p.Val11Ala Single submitter ⚠
- p.Val380Leu Single submitter ⚠
- p.Val419Phe Single submitter ⚠
- p.Val466Met Single submitter ⚠
- p.Val504Ile Single submitter ⚠
- p.Val90Leu Single submitter ⚠