DXO — 47 ClinVar variants
All ClinVar germline DXO variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
2 Likely benign · 45 Uncertain significance
Full DXO gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DXO p.Ala338Thr Uncertain significance Single submitter
- DXO p.Ala372Thr Uncertain significance Single submitter
- DXO p.Ala64Asp Uncertain significance Single submitter
- DXO p.Arg145Gln Uncertain significance Single submitter
- DXO p.Arg177Gln Uncertain significance Single submitter
- DXO p.Asn20Ser Uncertain significance Single submitter
- DXO p.Asp385Val Uncertain significance Single submitter
- DXO p.Asp55Glu Uncertain significance Single submitter
- DXO p.Glu144Lys Uncertain significance Single submitter
- DXO p.Gly148Ser Uncertain significance Single submitter
- DXO p.Gly359Ser Uncertain significance Single submitter
- DXO p.His261Asn Uncertain significance Single submitter
- DXO p.Leu103Pro Uncertain significance Single submitter
- DXO p.Leu107Arg Uncertain significance Single submitter
- DXO p.Leu110Pro Uncertain significance Single submitter
- DXO p.Leu349Phe Uncertain significance Single submitter
- DXO p.Met185Thr Uncertain significance Single submitter
- DXO p.Pro142Leu Uncertain significance Single submitter
- DXO p.Thr167Ile Uncertain significance Single submitter
- DXO p.Thr212Ala Uncertain significance Single submitter
- DXO p.Thr256Ile Uncertain significance Single submitter
- DXO p.Trp278Cys Uncertain significance Single submitter
- DXO p.Tyr36Cys Uncertain significance Single submitter
- DXO p.Val290Ile Uncertain significance Single submitter
- DXO p.Val363Met Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- DXO p.Arg155Gly Uncertain significance Single submitter
- DXO p.Arg177Trp Uncertain significance Single submitter
- DXO p.Arg221Cys Uncertain significance Single submitter
- DXO p.Arg221His Uncertain significance Single submitter
- DXO p.Arg221Leu Uncertain significance Single submitter
- DXO p.Arg319His Uncertain significance Single submitter
- DXO p.Gln150His Uncertain significance Single submitter
- DXO p.Glu380Ala Uncertain significance Single submitter
- DXO p.Gly79Asp Uncertain significance Single submitter
- DXO p.His134Gln Uncertain significance Single submitter
- DXO p.Pro168Leu Uncertain significance Single submitter
- DXO p.Pro179Leu Uncertain significance Single submitter
- DXO p.Pro179Ser Uncertain significance Single submitter
- DXO p.Pro243Leu Uncertain significance Single submitter
- DXO p.Ser301Phe Uncertain significance Single submitter
- DXO p.Thr341Met Uncertain significance Single submitter
- DXO p.Thr383Ile Uncertain significance Single submitter
- DXO p.Val252Met Uncertain significance Single submitter
- DXO p.Val300Leu Uncertain significance Single submitter
- DXO p.Val361Leu Uncertain significance Single submitter
All DXO variants
Likely benign 2
- p.Arg294Cys Single submitter
- p.Glu313Asp Single submitter
Uncertain significance 45
- p.Ala338Thr Single submitter ⚠
- p.Ala372Thr Single submitter ⚠
- p.Ala64Asp Single submitter ⚠
- p.Arg145Gln Single submitter ⚠
- p.Arg155Gly Single submitter ⚠
- p.Arg177Gln Single submitter ⚠
- p.Arg177Trp Single submitter ⚠
- p.Arg221Cys Single submitter ⚠
- p.Arg221His Single submitter ⚠
- p.Arg221Leu Single submitter ⚠
- p.Arg319His Single submitter ⚠
- p.Asn20Ser Single submitter ⚠
- p.Asp385Val Single submitter ⚠
- p.Asp55Glu Single submitter ⚠
- p.Gln150His Single submitter ⚠
- p.Glu144Lys Single submitter ⚠
- p.Glu380Ala Single submitter ⚠
- p.Gly148Ser Single submitter ⚠
- p.Gly359Ser Single submitter ⚠
- p.Gly79Asp Single submitter ⚠
- p.His134Gln Single submitter ⚠
- p.His261Asn Single submitter ⚠
- p.Leu103Pro Single submitter ⚠
- p.Leu107Arg Single submitter ⚠
- p.Leu110Pro Single submitter ⚠
- p.Leu349Phe Single submitter ⚠
- p.Met185Thr Single submitter ⚠
- p.Pro142Leu Single submitter ⚠
- p.Pro168Leu Single submitter ⚠
- p.Pro179Leu Single submitter ⚠
- p.Pro179Ser Single submitter ⚠
- p.Pro243Leu Single submitter ⚠
- p.Ser301Phe Single submitter ⚠
- p.Thr167Ile Single submitter ⚠
- p.Thr212Ala Single submitter ⚠
- p.Thr256Ile Single submitter ⚠
- p.Thr341Met Single submitter ⚠
- p.Thr383Ile Single submitter ⚠
- p.Trp278Cys Single submitter ⚠
- p.Tyr36Cys Single submitter ⚠
- p.Val252Met Single submitter ⚠
- p.Val290Ile Single submitter ⚠
- p.Val300Leu Single submitter ⚠
- p.Val361Leu Single submitter ⚠
- p.Val363Met Single submitter ⚠