DYDC1 — 24 ClinVar variants
All ClinVar germline DYDC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
2 Likely benign · 22 Uncertain significance
Full DYDC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DYDC1 p.Ala34Thr Uncertain significance Single submitter
- DYDC1 p.Arg59Cys Uncertain significance Single submitter
- DYDC1 p.Asp148Tyr Uncertain significance Single submitter
- DYDC1 p.Ile173Val Uncertain significance Single submitter
- DYDC1 p.Leu10Pro Uncertain significance Single submitter
- DYDC1 p.Leu123Val Uncertain significance Single submitter
- DYDC1 p.Leu49Arg Uncertain significance Single submitter
- DYDC1 p.Leu79Arg Uncertain significance Single submitter
- DYDC1 p.Met54Thr Uncertain significance Single submitter
- DYDC1 p.Met71Ile Uncertain significance Single submitter
- DYDC1 p.Pro26Arg Uncertain significance Single submitter
- DYDC1 p.Thr45Ala Uncertain significance Single submitter
- DYDC1 p.Trp36Ser Uncertain significance Single submitter
- DYDC1 p.Val27Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DYDC1 p.Arg25His Uncertain significance Single submitter
- DYDC1 p.Arg50Gly Uncertain significance Single submitter
- DYDC1 p.Gln111Pro Uncertain significance Single submitter
- DYDC1 p.Glu58Gly Uncertain significance Single submitter
- DYDC1 p.Gly151Glu Uncertain significance Single submitter
- DYDC1 p.Pro153Leu Uncertain significance Single submitter
- DYDC1 p.Ser147Arg Uncertain significance Single submitter
- DYDC1 p.Tyr40Cys Uncertain significance Single submitter
All DYDC1 variants
Likely benign 2
- p.Leu123Ile Single submitter
- p.Lys56Glu Single submitter
Uncertain significance 22
- p.Ala34Thr Single submitter ⚠
- p.Arg25His Single submitter ⚠
- p.Arg50Gly Single submitter ⚠
- p.Arg59Cys Single submitter ⚠
- p.Asp148Tyr Single submitter ⚠
- p.Gln111Pro Single submitter ⚠
- p.Glu58Gly Single submitter ⚠
- p.Gly151Glu Single submitter ⚠
- p.Ile173Val Single submitter ⚠
- p.Leu10Pro Single submitter ⚠
- p.Leu123Val Single submitter ⚠
- p.Leu49Arg Single submitter ⚠
- p.Leu79Arg Single submitter ⚠
- p.Met54Thr Single submitter ⚠
- p.Met71Ile Single submitter ⚠
- p.Pro153Leu Single submitter ⚠
- p.Pro26Arg Single submitter ⚠
- p.Ser147Arg Single submitter ⚠
- p.Thr45Ala Single submitter ⚠
- p.Trp36Ser Single submitter ⚠
- p.Tyr40Cys Single submitter ⚠
- p.Val27Met Single submitter ⚠