DYDC2 — 25 ClinVar variants
All ClinVar germline DYDC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
2 Benign · 3 Likely benign · 20 Uncertain significance
Full DYDC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DYDC2 p.Ala19Ser Uncertain significance Single submitter
- DYDC2 p.Ala44Thr Uncertain significance Single submitter
- DYDC2 p.Arg8Ser Uncertain significance Single submitter
- DYDC2 p.Asn50Ser Uncertain significance Single submitter
- DYDC2 p.Asn84His Uncertain significance Single submitter
- DYDC2 p.Glu48Val Uncertain significance Single submitter
- DYDC2 p.Glu59Gly Uncertain significance Single submitter
- DYDC2 p.Glu69Lys Uncertain significance Single submitter
- DYDC2 p.Gly131Arg Uncertain significance Single submitter
- DYDC2 p.Ile103Val Uncertain significance Single submitter
- DYDC2 p.Ile129Thr Uncertain significance Single submitter
- DYDC2 p.Lys101Glu Uncertain significance Single submitter
- DYDC2 p.Lys53Thr Uncertain significance Single submitter
- DYDC2 p.Met132Val Uncertain significance Single submitter
- DYDC2 p.Ser126Phe Uncertain significance Single submitter
- DYDC2 p.Thr99Met Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All DYDC2 variants
Benign 2
- c.148-2A>G Multiple submitters
- p.Val24Phe Single submitter
Likely benign 3
- p.Arg25Gln Single submitter
- p.Met68Thr Single submitter
- p.Val165Ile Single submitter
Uncertain significance 20
- p.Ala19Ser Single submitter ⚠
- p.Ala44Thr Single submitter ⚠
- p.Arg25Trp Single submitter ⚠
- p.Arg8Ser Single submitter ⚠
- p.Arg8Trp Single submitter ⚠
- p.Asn50Ser Single submitter ⚠
- p.Asn84His Single submitter ⚠
- p.Glu48Val Single submitter ⚠
- p.Glu59Gly Single submitter ⚠
- p.Glu69Lys Single submitter ⚠
- p.Gly131Arg Single submitter ⚠
- p.Ile103Val Single submitter ⚠
- p.Ile129Thr Single submitter ⚠
- p.Lys101Glu Single submitter ⚠
- p.Lys53Thr Single submitter ⚠
- p.Lys7Thr Single submitter ⚠
- p.Met132Val Single submitter ⚠
- p.Ser126Phe Single submitter ⚠
- p.Thr99Met Single submitter ⚠
- p.Val21Met Single submitter