DYNC1LI2 — 51 ClinVar variants
All ClinVar germline DYNC1LI2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
3 Likely benign · 48 Uncertain significance
Full DYNC1LI2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DYNC1LI2 p.Arg157His Uncertain significance Single submitter
- DYNC1LI2 p.Arg175Gln Uncertain significance Single submitter
- DYNC1LI2 p.Arg477Gln Uncertain significance Single submitter
- DYNC1LI2 p.Arg48Lys Uncertain significance Single submitter
- DYNC1LI2 p.Asn217Asp Uncertain significance Single submitter
- DYNC1LI2 p.Asn421Thr Uncertain significance Single submitter
- DYNC1LI2 p.Asn485Lys Uncertain significance Single submitter
- DYNC1LI2 p.Gln192His Uncertain significance Single submitter
- DYNC1LI2 p.Gly13Asp Uncertain significance Single submitter
- DYNC1LI2 p.Gly409Ser Uncertain significance Single submitter
- DYNC1LI2 p.Ile287Val Uncertain significance Single submitter
- DYNC1LI2 p.Leu280Phe Uncertain significance Single submitter
- DYNC1LI2 p.Lys9Arg Uncertain significance Single submitter
- DYNC1LI2 p.Lys9Gln Uncertain significance Single submitter
- DYNC1LI2 p.Met71Val Uncertain significance Single submitter
- DYNC1LI2 p.Pro187Leu Uncertain significance Single submitter
- DYNC1LI2 p.Pro187Ser Uncertain significance Single submitter
- DYNC1LI2 p.Ser92Asn Uncertain significance Single submitter
- DYNC1LI2 p.Ser92Gly Uncertain significance Single submitter
- DYNC1LI2 p.Thr329Ala Uncertain significance Single submitter
- DYNC1LI2 p.Val136Ile Uncertain significance Single submitter
- DYNC1LI2 p.Val229Ala Uncertain significance Single submitter
- DYNC1LI2 p.Val59Ile Uncertain significance Single submitter
- DYNC1LI2 p.Val6Leu Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- DYNC1LI2 p.Ala122Ser Uncertain significance Single submitter
- DYNC1LI2 p.Ala153Gly Uncertain significance Single submitter
- DYNC1LI2 p.Ala22Val Uncertain significance Single submitter
- DYNC1LI2 p.Arg103Cys Uncertain significance Single submitter
- DYNC1LI2 p.Arg157Cys Uncertain significance Single submitter
- DYNC1LI2 p.Arg397Trp Uncertain significance Single submitter
- DYNC1LI2 p.Asn105Ser Uncertain significance Single submitter
- DYNC1LI2 p.Asp351Asn Uncertain significance Single submitter
- DYNC1LI2 p.Gln264His Uncertain significance Single submitter
- DYNC1LI2 p.Gly293Ser Uncertain significance Single submitter
- DYNC1LI2 p.His244Arg Uncertain significance Single submitter
- DYNC1LI2 p.Leu89Val Uncertain significance Single submitter
- DYNC1LI2 p.Phe327Leu Uncertain significance Single submitter
- DYNC1LI2 p.Pro332Leu Uncertain significance Single submitter
- DYNC1LI2 p.Pro408Leu Uncertain significance Single submitter
- DYNC1LI2 p.Ser194Cys Uncertain significance Single submitter
- DYNC1LI2 p.Ser205Phe Uncertain significance Single submitter
- DYNC1LI2 p.Ser443Cys Uncertain significance Single submitter
- DYNC1LI2 p.Thr26Ile Uncertain significance Single submitter
- DYNC1LI2 p.Thr378Met Uncertain significance Single submitter
- DYNC1LI2 p.Thr410Met Uncertain significance Single submitter
- DYNC1LI2 p.Val341Leu Uncertain significance Single submitter
- DYNC1LI2 p.Val345Leu Uncertain significance Single submitter
- DYNC1LI2 p.Val452Met Uncertain significance Single submitter
All DYNC1LI2 variants
Likely benign 3
- c.108-6C>T Single submitter
- p.Leu74= Single submitter
- p.Met185Val Single submitter
Uncertain significance 48
- p.Ala122Ser Single submitter ⚠
- p.Ala153Gly Single submitter ⚠
- p.Ala22Val Single submitter ⚠
- p.Arg103Cys Single submitter ⚠
- p.Arg157Cys Single submitter ⚠
- p.Arg157His Single submitter ⚠
- p.Arg175Gln Single submitter ⚠
- p.Arg397Trp Single submitter ⚠
- p.Arg477Gln Single submitter ⚠
- p.Arg48Lys Single submitter ⚠
- p.Asn105Ser Single submitter ⚠
- p.Asn217Asp Single submitter ⚠
- p.Asn421Thr Single submitter ⚠
- p.Asn485Lys Single submitter ⚠
- p.Asp351Asn Single submitter ⚠
- p.Gln192His Single submitter ⚠
- p.Gln264His Single submitter ⚠
- p.Gly13Asp Single submitter ⚠
- p.Gly293Ser Single submitter ⚠
- p.Gly409Ser Single submitter ⚠
- p.His244Arg Single submitter ⚠
- p.Ile287Val Single submitter ⚠
- p.Leu280Phe Single submitter ⚠
- p.Leu89Val Single submitter ⚠
- p.Lys9Arg Single submitter ⚠
- p.Lys9Gln Single submitter ⚠
- p.Met71Val Single submitter ⚠
- p.Phe327Leu Single submitter ⚠
- p.Pro187Leu Single submitter ⚠
- p.Pro187Ser Single submitter ⚠
- p.Pro332Leu Single submitter ⚠
- p.Pro408Leu Single submitter ⚠
- p.Ser194Cys Single submitter ⚠
- p.Ser205Phe Single submitter ⚠
- p.Ser443Cys Single submitter ⚠
- p.Ser92Asn Single submitter ⚠
- p.Ser92Gly Single submitter ⚠
- p.Thr26Ile Single submitter ⚠
- p.Thr329Ala Single submitter ⚠
- p.Thr378Met Single submitter ⚠
- p.Thr410Met Single submitter ⚠
- p.Val136Ile Single submitter ⚠
- p.Val229Ala Single submitter ⚠
- p.Val341Leu Single submitter ⚠
- p.Val345Leu Single submitter ⚠
- p.Val452Met Single submitter ⚠
- p.Val59Ile Single submitter ⚠
- p.Val6Leu Single submitter ⚠