DYNLRB1 — 9 ClinVar variants
All ClinVar germline DYNLRB1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
9 Uncertain significance
Full DYNLRB1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DYNLRB1 p.His47Gln Uncertain significance Single submitter
- DYNLRB1 p.Ile30Val Uncertain significance Single submitter
- DYNLRB1 p.Met46Ile Uncertain significance Single submitter
- DYNLRB1 p.Ser55Asn Uncertain significance Single submitter
- DYNLRB1 p.Thr25Ala Uncertain significance Single submitter
- DYNLRB1 p.Tyr86Cys Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All DYNLRB1 variants
Uncertain significance 9
- p.Asp61Asn Single submitter ⚠
- p.His47Gln Single submitter ⚠
- p.Ile30Val Single submitter ⚠
- p.Met46Ile Single submitter ⚠
- p.Ser55Asn Single submitter ⚠
- p.Thr25Ala Single submitter ⚠
- p.Tyr86Cys Single submitter ⚠
- p.Val23Met Single submitter ⚠
- p.Val57Met Single submitter ⚠