DYNLRB2 — 29 ClinVar variants
All ClinVar germline DYNLRB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
1 Benign · 28 Uncertain significance
Full DYNLRB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DYNLRB2 p.Asn64Lys Uncertain significance Single submitter
- DYNLRB2 p.Leu46Pro Uncertain significance Single submitter
- DYNLRB2 p.Ser73Pro Uncertain significance Single submitter
- DYNLRB2 p.Val17Leu Uncertain significance Single submitter
- DYNLRB2 p.Val22Ala Uncertain significance Single submitter
- DYNLRB2 p.Val90Leu Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- DYNLRB2 p.Arg10Lys Uncertain significance Single submitter
- DYNLRB2 p.Arg58Cys Uncertain significance Single submitter
- DYNLRB2 p.Arg58His Uncertain significance Single submitter
- DYNLRB2 p.Asn36Thr Uncertain significance Single submitter
- DYNLRB2 p.Asn93Ile Uncertain significance Single submitter
- DYNLRB2 p.Asp83Gly Uncertain significance Single submitter
- DYNLRB2 p.Glu3Asp Uncertain significance Single submitter
- DYNLRB2 p.Glu85Lys Uncertain significance Single submitter
- DYNLRB2 p.His76Tyr Uncertain significance Single submitter
- DYNLRB2 p.Ile60Thr Uncertain significance Single submitter
- DYNLRB2 p.Ile91Val Uncertain significance Single submitter
- DYNLRB2 p.Leu45Val Uncertain significance Single submitter
- DYNLRB2 p.Lys15Asn Uncertain significance Single submitter
- DYNLRB2 p.Lys74Glu Uncertain significance Single submitter
- DYNLRB2 p.Met51Thr Uncertain significance Single submitter
- DYNLRB2 p.Pro29Ser Uncertain significance Single submitter
- DYNLRB2 p.Ser13Asn Uncertain significance Single submitter
- DYNLRB2 p.Ser55Ile Uncertain significance Single submitter
- DYNLRB2 p.Thr67Asn Uncertain significance Single submitter
- DYNLRB2 p.Val4Met Uncertain significance Single submitter
- DYNLRB2 p.Val80Ile Uncertain significance Single submitter
- DYNLRB2 p.Val90Ile Uncertain significance Single submitter
All DYNLRB2 variants
Benign 1
- p.Leu66= Multiple submitters
Uncertain significance 28
- p.Arg10Lys Single submitter ⚠
- p.Arg58Cys Single submitter ⚠
- p.Arg58His Single submitter ⚠
- p.Asn36Thr Single submitter ⚠
- p.Asn64Lys Single submitter ⚠
- p.Asn93Ile Single submitter ⚠
- p.Asp83Gly Single submitter ⚠
- p.Glu3Asp Single submitter ⚠
- p.Glu85Lys Single submitter ⚠
- p.His76Tyr Single submitter ⚠
- p.Ile60Thr Single submitter ⚠
- p.Ile91Val Single submitter ⚠
- p.Leu45Val Single submitter ⚠
- p.Leu46Pro Single submitter ⚠
- p.Lys15Asn Single submitter ⚠
- p.Lys74Glu Single submitter ⚠
- p.Met51Thr Single submitter ⚠
- p.Pro29Ser Single submitter ⚠
- p.Ser13Asn Single submitter ⚠
- p.Ser55Ile Single submitter ⚠
- p.Ser73Pro Single submitter ⚠
- p.Thr67Asn Single submitter ⚠
- p.Val17Leu Single submitter ⚠
- p.Val22Ala Single submitter ⚠
- p.Val4Met Single submitter ⚠
- p.Val80Ile Single submitter ⚠
- p.Val90Ile Single submitter ⚠
- p.Val90Leu Single submitter ⚠