DYNLT1 — 21 ClinVar variants
All ClinVar germline DYNLT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
21 Uncertain significance
Full DYNLT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DYNLT1 p.Asp90Asn Uncertain significance Single submitter
- DYNLT1 p.Gln5Glu Uncertain significance Single submitter
- DYNLT1 p.Glu26Gly Uncertain significance Single submitter
- DYNLT1 p.Ile105Met Uncertain significance Single submitter
- DYNLT1 p.Leu54Phe Uncertain significance Single submitter
- DYNLT1 p.Met102Thr Uncertain significance Single submitter
- DYNLT1 p.Ser82Cys Uncertain significance Single submitter
- DYNLT1 p.Tyr34Cys Uncertain significance Single submitter
- DYNLT1 p.Tyr4Asn Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- DYNLT1 p.Ala33Thr Uncertain significance Single submitter
- DYNLT1 p.Ile113Val Uncertain significance Single submitter
- DYNLT1 p.Ile20Thr Uncertain significance Single submitter
- DYNLT1 p.Ile25Met Uncertain significance Single submitter
- DYNLT1 p.Ile29Val Uncertain significance Single submitter
- DYNLT1 p.Ile64Val Uncertain significance Single submitter
- DYNLT1 p.Lys38Arg Uncertain significance Single submitter
- DYNLT1 p.Lys56Arg Uncertain significance Single submitter
- DYNLT1 p.Ser92Asn Uncertain significance Single submitter
- DYNLT1 p.Thr66Ile Uncertain significance Single submitter
- DYNLT1 p.Val14Gly Uncertain significance Single submitter
- DYNLT1 p.Val21Leu Uncertain significance Single submitter
All DYNLT1 variants
Uncertain significance 21
- p.Ala33Thr Single submitter ⚠
- p.Asp90Asn Single submitter ⚠
- p.Gln5Glu Single submitter ⚠
- p.Glu26Gly Single submitter ⚠
- p.Ile105Met Single submitter ⚠
- p.Ile113Val Single submitter ⚠
- p.Ile20Thr Single submitter ⚠
- p.Ile25Met Single submitter ⚠
- p.Ile29Val Single submitter ⚠
- p.Ile64Val Single submitter ⚠
- p.Leu54Phe Single submitter ⚠
- p.Lys38Arg Single submitter ⚠
- p.Lys56Arg Single submitter ⚠
- p.Met102Thr Single submitter ⚠
- p.Ser82Cys Single submitter ⚠
- p.Ser92Asn Single submitter ⚠
- p.Thr66Ile Single submitter ⚠
- p.Tyr34Cys Single submitter ⚠
- p.Tyr4Asn Single submitter ⚠
- p.Val14Gly Single submitter ⚠
- p.Val21Leu Single submitter ⚠