DYNLT2 — 29 ClinVar variants
All ClinVar germline DYNLT2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
3 Likely benign · 26 Uncertain significance
Full DYNLT2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DYNLT2 p.Ala178Thr Uncertain significance Single submitter
- DYNLT2 p.Ala23Ser Uncertain significance Single submitter
- DYNLT2 p.Ala68Thr Uncertain significance Single submitter
- DYNLT2 p.Ala84Ser Uncertain significance Single submitter
- DYNLT2 p.Arg144Cys Uncertain significance Single submitter
- DYNLT2 p.Arg144His Uncertain significance Single submitter
- DYNLT2 p.Arg46Thr Uncertain significance Single submitter
- DYNLT2 p.Arg50Gly Uncertain significance Single submitter
- DYNLT2 p.Asn55Ser Uncertain significance Single submitter
- DYNLT2 p.Asp69Gly Uncertain significance Single submitter
- DYNLT2 p.Glu39Lys Uncertain significance Single submitter
- DYNLT2 p.Glu51Lys Uncertain significance Single submitter
- DYNLT2 p.Gly5Ser Uncertain significance Single submitter
- DYNLT2 p.Lys116Arg Uncertain significance Single submitter
- DYNLT2 p.Lys72Glu Uncertain significance Single submitter
- DYNLT2 p.Trp169Arg Uncertain significance Single submitter
- DYNLT2 p.Trp173Ser Uncertain significance Single submitter
- DYNLT2 p.Tyr197His Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DYNLT2 p.Ala130Val Uncertain significance Single submitter
- DYNLT2 p.Ala164Val Uncertain significance Single submitter
- DYNLT2 p.Arg132Cys Uncertain significance Single submitter
- DYNLT2 p.Arg28Gly Uncertain significance Single submitter
- DYNLT2 p.Asp114Gly Uncertain significance Single submitter
- DYNLT2 p.Asp114His Uncertain significance Single submitter
- DYNLT2 p.Glu184Gly Uncertain significance Single submitter
- DYNLT2 p.Tyr186Cys Uncertain significance Single submitter
All DYNLT2 variants
Likely benign 3
- p.Ala23Pro Single submitter
- p.Val104Ile Single submitter
- p.Val187Met Single submitter
Uncertain significance 26
- p.Ala130Val Single submitter ⚠
- p.Ala164Val Single submitter ⚠
- p.Ala178Thr Single submitter ⚠
- p.Ala23Ser Single submitter ⚠
- p.Ala68Thr Single submitter ⚠
- p.Ala84Ser Single submitter ⚠
- p.Arg132Cys Single submitter ⚠
- p.Arg144Cys Single submitter ⚠
- p.Arg144His Single submitter ⚠
- p.Arg28Gly Single submitter ⚠
- p.Arg46Thr Single submitter ⚠
- p.Arg50Gly Single submitter ⚠
- p.Asn55Ser Single submitter ⚠
- p.Asp114Gly Single submitter ⚠
- p.Asp114His Single submitter ⚠
- p.Asp69Gly Single submitter ⚠
- p.Glu184Gly Single submitter ⚠
- p.Glu39Lys Single submitter ⚠
- p.Glu51Lys Single submitter ⚠
- p.Gly5Ser Single submitter ⚠
- p.Lys116Arg Single submitter ⚠
- p.Lys72Glu Single submitter ⚠
- p.Trp169Arg Single submitter ⚠
- p.Trp173Ser Single submitter ⚠
- p.Tyr186Cys Single submitter ⚠
- p.Tyr197His Single submitter ⚠