DYNLT4 — 57 ClinVar variants
All ClinVar germline DYNLT4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
2 Likely benign · 55 Uncertain significance
Full DYNLT4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DYNLT4 p.Ala41Ser Uncertain significance Single submitter
- DYNLT4 p.Arg179His Uncertain significance Single submitter
- DYNLT4 p.Arg179Leu Uncertain significance Single submitter
- DYNLT4 p.Arg196His Uncertain significance Single submitter
- DYNLT4 p.Asp197Asn Uncertain significance Single submitter
- DYNLT4 p.Gly20Arg Uncertain significance Single submitter
- DYNLT4 p.Gly71Arg Uncertain significance Single submitter
- DYNLT4 p.Gly73Ala Uncertain significance Single submitter
- DYNLT4 p.Pro85Ser Uncertain significance Single submitter
- DYNLT4 p.Pro86Leu Uncertain significance Single submitter
- DYNLT4 p.Ser188Arg Uncertain significance Single submitter
- DYNLT4 p.Ser201Pro Uncertain significance Single submitter
- DYNLT4 p.Ser60Ala Uncertain significance Single submitter
- DYNLT4 p.Val186Ala Uncertain significance Single submitter
-
DYNLT4 p.Ala211Pro
Uncertain significance
No assertion criteria
neurodevelopmental disorder
Predictors split 40
The independent predictors disagree with each other — read with care.
- DYNLT4 p.Ala130Ser Uncertain significance Single submitter
- DYNLT4 p.Ala146Thr Uncertain significance Single submitter
- DYNLT4 p.Ala146Val Uncertain significance Single submitter
- DYNLT4 p.Ala195Val Uncertain significance Single submitter
- DYNLT4 p.Ala58Thr Uncertain significance Single submitter
- DYNLT4 p.Ala72Thr Uncertain significance Single submitter
- DYNLT4 p.Arg102His Uncertain significance Single submitter
- DYNLT4 p.Arg109His Uncertain significance Single submitter
- DYNLT4 p.Arg117Pro Uncertain significance Single submitter
- DYNLT4 p.Arg161Cys Uncertain significance Single submitter
- DYNLT4 p.Arg167His Uncertain significance Single submitter
- DYNLT4 p.Arg27Trp Uncertain significance Single submitter
- DYNLT4 p.Arg29Gln Uncertain significance Single submitter
- DYNLT4 p.Arg64Leu Uncertain significance Single submitter
- DYNLT4 p.Arg78Gln Uncertain significance Single submitter
- DYNLT4 p.Gln182Arg Uncertain significance Single submitter
- DYNLT4 p.Glu116Asp Uncertain significance Single submitter
- DYNLT4 p.Glu12Lys Uncertain significance Single submitter
- DYNLT4 p.Glu144Lys Uncertain significance Single submitter
- DYNLT4 p.Gly115Glu Uncertain significance Single submitter
- DYNLT4 p.Gly181Arg Uncertain significance Single submitter
- DYNLT4 p.Gly217Arg Uncertain significance Single submitter
- DYNLT4 p.Gly44Asp Uncertain significance Single submitter
- DYNLT4 p.Gly71Asp Uncertain significance Single submitter
- DYNLT4 p.Gly71Val Uncertain significance Single submitter
- DYNLT4 p.Gly82Ser Uncertain significance Single submitter
- DYNLT4 p.Leu127Met Uncertain significance Single submitter
- DYNLT4 p.Leu127Pro Uncertain significance Single submitter
- DYNLT4 p.Leu199Met Uncertain significance Single submitter
- DYNLT4 p.Leu81Met Uncertain significance Single submitter
- DYNLT4 p.Lys169Arg Uncertain significance Single submitter
- DYNLT4 p.Pro40Thr Uncertain significance Single submitter
- DYNLT4 p.Pro97Leu Uncertain significance Single submitter
- DYNLT4 p.Ser173Arg Uncertain significance Single submitter
- DYNLT4 p.Ser3Asn Uncertain significance Single submitter
- DYNLT4 p.Ser60Cys Uncertain significance Single submitter
- DYNLT4 p.Ser60Phe Uncertain significance Single submitter
- DYNLT4 p.Thr214Met Uncertain significance Single submitter
- DYNLT4 p.Tyr168Cys Uncertain significance Single submitter
- DYNLT4 p.Val186Met Uncertain significance Single submitter
All DYNLT4 variants
Likely benign 2
- p.Arg29Pro Single submitter
- p.Gly82= Single submitter
Uncertain significance 55
- p.Ala130Ser Single submitter ⚠
- p.Ala146Thr Single submitter ⚠
- p.Ala146Val Single submitter ⚠
- p.Ala195Val Single submitter ⚠
- p.Ala41Ser Single submitter ⚠
- p.Ala58Thr Single submitter ⚠
- p.Ala72Thr Single submitter ⚠
- p.Arg102His Single submitter ⚠
- p.Arg109His Single submitter ⚠
- p.Arg117Pro Single submitter ⚠
- p.Arg161Cys Single submitter ⚠
- p.Arg167His Single submitter ⚠
- p.Arg179His Single submitter ⚠
- p.Arg179Leu Single submitter ⚠
- p.Arg196His Single submitter ⚠
- p.Arg27Trp Single submitter ⚠
- p.Arg29Gln Single submitter ⚠
- p.Arg64Leu Single submitter ⚠
- p.Arg78Gln Single submitter ⚠
- p.Asp197Asn Single submitter ⚠
- p.Gln182Arg Single submitter ⚠
- p.Glu116Asp Single submitter ⚠
- p.Glu12Lys Single submitter ⚠
- p.Glu144Lys Single submitter ⚠
- p.Gly115Glu Single submitter ⚠
- p.Gly181Arg Single submitter ⚠
- p.Gly20Arg Single submitter ⚠
- p.Gly217Arg Single submitter ⚠
- p.Gly44Asp Single submitter ⚠
- p.Gly71Arg Single submitter ⚠
- p.Gly71Asp Single submitter ⚠
- p.Gly71Val Single submitter ⚠
- p.Gly73Ala Single submitter ⚠
- p.Gly82Ser Single submitter ⚠
- p.Leu127Met Single submitter ⚠
- p.Leu127Pro Single submitter ⚠
- p.Leu199Met Single submitter ⚠
- p.Leu81Met Single submitter ⚠
- p.Lys169Arg Single submitter ⚠
- p.Pro40Thr Single submitter ⚠
- p.Pro85Ser Single submitter ⚠
- p.Pro86Leu Single submitter ⚠
- p.Pro97Leu Single submitter ⚠
- p.Ser173Arg Single submitter ⚠
- p.Ser188Arg Single submitter ⚠
- p.Ser201Pro Single submitter ⚠
- p.Ser3Asn Single submitter ⚠
- p.Ser60Ala Single submitter ⚠
- p.Ser60Cys Single submitter ⚠
- p.Ser60Phe Single submitter ⚠
- p.Thr214Met Single submitter ⚠
- p.Tyr168Cys Single submitter ⚠
- p.Val186Ala Single submitter ⚠
- p.Val186Met Single submitter ⚠
- p.Ala211Pro No assertion criteria neurodevelopmental disorder ⚠