DYNLT5 — 29 ClinVar variants
All ClinVar germline DYNLT5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Likely benign · 28 Uncertain significance
Full DYNLT5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DYNLT5 p.Arg37His Uncertain significance Single submitter
- DYNLT5 p.Arg54Cys Uncertain significance Single submitter
- DYNLT5 p.Arg54His Uncertain significance Single submitter
- DYNLT5 p.Asn26His Uncertain significance Single submitter
- DYNLT5 p.Asn6Lys Uncertain significance Single submitter
- DYNLT5 p.Glu28Lys Uncertain significance Single submitter
- DYNLT5 p.Glu97Lys Uncertain significance Single submitter
- DYNLT5 p.Gly71Val Uncertain significance Single submitter
- DYNLT5 p.Gly9Ser Uncertain significance Single submitter
- DYNLT5 p.Ile21Thr Uncertain significance Single submitter
- DYNLT5 p.Leu167Pro Uncertain significance Single submitter
- DYNLT5 p.Pro73Leu Uncertain significance Single submitter
- DYNLT5 p.Ser166Pro Uncertain significance Single submitter
- DYNLT5 p.Ser25Arg Uncertain significance Single submitter
- DYNLT5 p.Val173Leu Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- DYNLT5 p.Ala169Ser Uncertain significance Single submitter
- DYNLT5 p.Arg125Gln Uncertain significance Single submitter
- DYNLT5 p.Arg125Trp Uncertain significance Single submitter
- DYNLT5 p.Arg31Gln Likely benign Single submitter
- DYNLT5 p.Asp120Asn Uncertain significance Single submitter
- DYNLT5 p.Asp87Gly Uncertain significance Single submitter
- DYNLT5 p.Gln136Arg Uncertain significance Single submitter
- DYNLT5 p.Ile144Thr Uncertain significance Single submitter
- DYNLT5 p.Leu149Phe Uncertain significance Single submitter
- DYNLT5 p.Leu93Val Uncertain significance Single submitter
- DYNLT5 p.Pro72Leu Uncertain significance Single submitter
- DYNLT5 p.Ser43Ile Uncertain significance Single submitter
- DYNLT5 p.Thr80Pro Uncertain significance Single submitter
- DYNLT5 p.Val81Ile Uncertain significance Single submitter
All DYNLT5 variants
Likely benign 1
- p.Arg31Gln Single submitter ⚠
Uncertain significance 28
- p.Ala169Ser Single submitter ⚠
- p.Arg125Gln Single submitter ⚠
- p.Arg125Trp Single submitter ⚠
- p.Arg37His Single submitter ⚠
- p.Arg54Cys Single submitter ⚠
- p.Arg54His Single submitter ⚠
- p.Asn26His Single submitter ⚠
- p.Asn6Lys Single submitter ⚠
- p.Asp120Asn Single submitter ⚠
- p.Asp87Gly Single submitter ⚠
- p.Gln136Arg Single submitter ⚠
- p.Glu28Lys Single submitter ⚠
- p.Glu97Lys Single submitter ⚠
- p.Gly71Val Single submitter ⚠
- p.Gly9Ser Single submitter ⚠
- p.Ile144Thr Single submitter ⚠
- p.Ile21Thr Single submitter ⚠
- p.Leu149Phe Single submitter ⚠
- p.Leu167Pro Single submitter ⚠
- p.Leu93Val Single submitter ⚠
- p.Pro72Leu Single submitter ⚠
- p.Pro73Leu Single submitter ⚠
- p.Ser166Pro Single submitter ⚠
- p.Ser25Arg Single submitter ⚠
- p.Ser43Ile Single submitter ⚠
- p.Thr80Pro Single submitter ⚠
- p.Val173Leu Single submitter ⚠
- p.Val81Ile Single submitter ⚠