DYRK2 — 65 ClinVar variants
All ClinVar germline DYRK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
1 Benign · 2 Likely benign · 62 Uncertain significance
Full DYRK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DYRK2 p.Ala581Val Uncertain significance Single submitter
- DYRK2 p.Ala9Val Uncertain significance Single submitter
- DYRK2 p.Arg125Gln Uncertain significance Single submitter
- DYRK2 p.Arg268Gln Uncertain significance Single submitter
- DYRK2 p.Arg326His Uncertain significance Single submitter
- DYRK2 p.Arg398Thr Uncertain significance Single submitter
- DYRK2 p.Arg481Cys Uncertain significance Single submitter
- DYRK2 p.Asn109Asp Uncertain significance Single submitter
- DYRK2 p.Asn200Ser Uncertain significance Single submitter
- DYRK2 p.Asn498Lys Uncertain significance Single submitter
- DYRK2 p.Asn498Ser Uncertain significance Single submitter
- DYRK2 p.Asn59Ile Uncertain significance Single submitter
- DYRK2 p.Asn59Ser Uncertain significance Single submitter
- DYRK2 p.Asn75Ser Uncertain significance Single submitter
- DYRK2 p.Asp21Gly Uncertain significance Single submitter
- DYRK2 p.Cys433Ser Uncertain significance Single submitter
- DYRK2 p.Gln192His Uncertain significance Single submitter
- DYRK2 p.Glu352Lys Uncertain significance Single submitter
- DYRK2 p.Gly69Ser Uncertain significance Single submitter
- DYRK2 p.His65Tyr Uncertain significance Single submitter
- DYRK2 p.His72Gln Uncertain significance Single submitter
- DYRK2 p.Lys141Thr Uncertain significance Single submitter
- DYRK2 p.Lys459Glu Uncertain significance Single submitter
- DYRK2 p.Met164Ile Uncertain significance Single submitter
- DYRK2 p.Pro214Leu Uncertain significance Single submitter
- DYRK2 p.Pro47Leu Uncertain significance Single submitter
- DYRK2 p.Pro568Ser Uncertain significance Single submitter
- DYRK2 p.Ser129Asn Uncertain significance Single submitter
- DYRK2 p.Ser407Arg Uncertain significance Single submitter
- DYRK2 p.Ser58Asn Uncertain significance Single submitter
- DYRK2 p.Ser82Arg Uncertain significance Single submitter
- DYRK2 p.Thr38Ile Uncertain significance Single submitter
- DYRK2 p.Thr417Met Uncertain significance Single submitter
- DYRK2 p.Thr554Ala Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- DYRK2 p.Ala413Gly Uncertain significance Single submitter
- DYRK2 p.Ala499Thr Uncertain significance Single submitter
- DYRK2 p.Ala499Val Uncertain significance Single submitter
- DYRK2 p.Arg274Trp Uncertain significance Single submitter
- DYRK2 p.Arg378Cys Uncertain significance Single submitter
- DYRK2 p.Arg481His Uncertain significance Single submitter
- DYRK2 p.Asn454Lys Uncertain significance Single submitter
- DYRK2 p.Asp206Asn Uncertain significance Single submitter
- DYRK2 p.Glu180Asp Uncertain significance Single submitter
- DYRK2 p.Gly201Asp Uncertain significance Single submitter
- DYRK2 p.Leu470Val Uncertain significance Single submitter
- DYRK2 p.Met164Val Uncertain significance Single submitter
- DYRK2 p.Met524Val Uncertain significance Single submitter
- DYRK2 p.Pro533Ser Uncertain significance Single submitter
- DYRK2 p.Pro533Thr Uncertain significance Single submitter
- DYRK2 p.Ser22Ile Uncertain significance Single submitter
- DYRK2 p.Ser442Leu Uncertain significance Single submitter
- DYRK2 p.Ser474Phe Uncertain significance Single submitter
- DYRK2 p.Thr105Met Uncertain significance Single submitter
- DYRK2 p.Thr117Met Uncertain significance Single submitter
- DYRK2 p.Thr281Ala Uncertain significance Single submitter
- DYRK2 p.Thr466Ser Uncertain significance Single submitter
- DYRK2 p.Thr548Met Uncertain significance Single submitter
- DYRK2 p.Thr66Lys Uncertain significance Single submitter
- DYRK2 p.Tyr163Cys Uncertain significance Single submitter
- DYRK2 p.Val213Met Uncertain significance Single submitter
- DYRK2 p.Val248Met Uncertain significance Single submitter
- DYRK2 p.Val476Ala Uncertain significance Single submitter
All DYRK2 variants
Benign 1
- p.Pro11= Single submitter
Uncertain significance 62
- p.Ala413Gly Single submitter ⚠
- p.Ala499Thr Single submitter ⚠
- p.Ala499Val Single submitter ⚠
- p.Ala581Val Single submitter ⚠
- p.Ala9Val Single submitter ⚠
- p.Arg125Gln Single submitter ⚠
- p.Arg268Gln Single submitter ⚠
- p.Arg274Trp Single submitter ⚠
- p.Arg326His Single submitter ⚠
- p.Arg378Cys Single submitter ⚠
- p.Arg398Thr Single submitter ⚠
- p.Arg481Cys Single submitter ⚠
- p.Arg481His Single submitter ⚠
- p.Asn109Asp Single submitter ⚠
- p.Asn200Ser Single submitter ⚠
- p.Asn454Lys Single submitter ⚠
- p.Asn498Lys Single submitter ⚠
- p.Asn498Ser Single submitter ⚠
- p.Asn59Ile Single submitter ⚠
- p.Asn59Ser Single submitter ⚠
- p.Asn75Ser Single submitter ⚠
- p.Asp206Asn Single submitter ⚠
- p.Asp21Gly Single submitter ⚠
- p.Cys433Ser Single submitter ⚠
- p.Gln192His Single submitter ⚠
- p.Glu180Asp Single submitter ⚠
- p.Glu352Lys Single submitter ⚠
- p.Gly201Asp Single submitter ⚠
- p.Gly69Ser Single submitter ⚠
- p.His65Tyr Single submitter ⚠
- p.His72Gln Single submitter ⚠
- p.Leu470Val Single submitter ⚠
- p.Lys141Thr Single submitter ⚠
- p.Lys459Glu Single submitter ⚠
- p.Met164Ile Single submitter ⚠
- p.Met164Val Single submitter ⚠
- p.Met524Val Single submitter ⚠
- p.Pro214Leu Single submitter ⚠
- p.Pro47Leu Single submitter ⚠
- p.Pro533Ser Single submitter ⚠
- p.Pro533Thr Single submitter ⚠
- p.Pro568Ser Single submitter ⚠
- p.Ser129Asn Single submitter ⚠
- p.Ser22Ile Single submitter ⚠
- p.Ser407Arg Single submitter ⚠
- p.Ser442Leu Single submitter ⚠
- p.Ser474Phe Single submitter ⚠
- p.Ser58Asn Single submitter ⚠
- p.Ser82Arg Single submitter ⚠
- p.Thr105Met Single submitter ⚠
- p.Thr117Met Single submitter ⚠
- p.Thr281Ala Single submitter ⚠
- p.Thr38Ile Single submitter ⚠
- p.Thr417Met Single submitter ⚠
- p.Thr466Ser Single submitter ⚠
- p.Thr548Met Single submitter ⚠
- p.Thr554Ala Single submitter ⚠
- p.Thr66Lys Single submitter ⚠
- p.Tyr163Cys Single submitter ⚠
- p.Val213Met Single submitter ⚠
- p.Val248Met Single submitter ⚠
- p.Val476Ala Single submitter ⚠