DYRK3 — 73 ClinVar variants
All ClinVar germline DYRK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 70 flagged for review →
3 Likely benign · 70 Uncertain significance
Full DYRK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 70
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DYRK3 p.Ala509Ser Uncertain significance Single submitter
- DYRK3 p.Ala514Gly Uncertain significance Single submitter
- DYRK3 p.Arg241His Uncertain significance Single submitter
- DYRK3 p.Arg245His Uncertain significance Single submitter
- DYRK3 p.Arg25Gln Uncertain significance Single submitter
- DYRK3 p.Arg385His Uncertain significance Single submitter
- DYRK3 p.Arg470Gly Uncertain significance Single submitter
- DYRK3 p.Arg475Gln Uncertain significance Single submitter
- DYRK3 p.Arg475Pro Uncertain significance Single submitter
- DYRK3 p.Arg510Cys Uncertain significance Single submitter
- DYRK3 p.Arg540Gln Uncertain significance Single submitter
- DYRK3 p.Asp194Tyr Uncertain significance Single submitter
- DYRK3 p.Asp264Asn Uncertain significance Single submitter
- DYRK3 p.Asp335His Uncertain significance Single submitter
- DYRK3 p.Asp534Gly Uncertain significance Single submitter
- DYRK3 p.Cys123Arg Uncertain significance Single submitter
- DYRK3 p.Gln515His Uncertain significance Single submitter
- DYRK3 p.Gln68Arg Uncertain significance Single submitter
- DYRK3 p.Gln90Glu Uncertain significance Single submitter
- DYRK3 p.Glu362Lys Uncertain significance Single submitter
- DYRK3 p.Gly347Trp Uncertain significance Single submitter
- DYRK3 p.Gly575Ser Uncertain significance Single submitter
- DYRK3 p.His283Arg Uncertain significance Single submitter
- DYRK3 p.Ile38Val Uncertain significance Single submitter
- DYRK3 p.Ile577Lys Uncertain significance Single submitter
- DYRK3 p.Leu323Trp Uncertain significance Single submitter
- DYRK3 p.Lys110Glu Uncertain significance Single submitter
- DYRK3 p.Lys300Glu Uncertain significance Single submitter
- DYRK3 p.Met239Ile Uncertain significance Single submitter
- DYRK3 p.Met274Leu Uncertain significance Single submitter
- DYRK3 p.Met570Thr Uncertain significance Single submitter
- DYRK3 p.Met83Leu Uncertain significance Single submitter
- DYRK3 p.Pro410Leu Uncertain significance Single submitter
- DYRK3 p.Pro410Thr Uncertain significance Single submitter
- DYRK3 p.Pro44Ala Uncertain significance Single submitter
- DYRK3 p.Pro44Leu Uncertain significance Single submitter
- DYRK3 p.Pro520Arg Uncertain significance Single submitter
- DYRK3 p.Ser358Phe Uncertain significance Single submitter
- DYRK3 p.Ser537Leu Uncertain significance Single submitter
- DYRK3 p.Thr532Ile Uncertain significance Single submitter
- DYRK3 p.Thr66Pro Uncertain significance Single submitter
- DYRK3 p.Trp393Arg Uncertain significance Single submitter
- DYRK3 p.Tyr451Cys Uncertain significance Single submitter
- DYRK3 p.Val127Ile Uncertain significance Single submitter
- DYRK3 p.Val559Leu Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- DYRK3 p.Ala316Ser Uncertain significance Single submitter
- DYRK3 p.Arg248Cys Uncertain significance Single submitter
- DYRK3 p.Arg255Gln Uncertain significance Single submitter
- DYRK3 p.Arg255Trp Uncertain significance Single submitter
- DYRK3 p.Arg313Cys Uncertain significance Single submitter
- DYRK3 p.Arg348Cys Uncertain significance Single submitter
- DYRK3 p.Arg348His Uncertain significance Single submitter
- DYRK3 p.Arg470His Uncertain significance Single submitter
- DYRK3 p.Arg471Ser Uncertain significance Single submitter
- DYRK3 p.Asn186Ser Uncertain significance Single submitter
- DYRK3 p.Asn302Ser Uncertain significance Single submitter
- DYRK3 p.Asp192Asn Uncertain significance Single submitter
- DYRK3 p.Glu144Gln Uncertain significance Single submitter
- DYRK3 p.Glu276Gly Uncertain significance Single submitter
- DYRK3 p.His247Arg Uncertain significance Single submitter
- DYRK3 p.Ile390Val Uncertain significance Single submitter
- DYRK3 p.Leu464Phe Uncertain significance Single submitter
- DYRK3 p.Lys265Glu Uncertain significance Single submitter
- DYRK3 p.Lys524Asn Uncertain significance Single submitter
- DYRK3 p.Met422Val Uncertain significance Single submitter
- DYRK3 p.Pro429Gln Uncertain significance Single submitter
- DYRK3 p.Pro507Ala Uncertain significance Single submitter
- DYRK3 p.Ser120Arg Uncertain significance Single submitter
- DYRK3 p.Ser129Phe Uncertain significance Single submitter
- DYRK3 p.Ser453Pro Uncertain significance Single submitter
All DYRK3 variants
Likely benign 3
- p.Ile100Val Single submitter
- p.Thr279= Single submitter
- p.Val309Ile Single submitter
Uncertain significance 70
- p.Ala316Ser Single submitter ⚠
- p.Ala509Ser Single submitter ⚠
- p.Ala514Gly Single submitter ⚠
- p.Arg241His Single submitter ⚠
- p.Arg245His Single submitter ⚠
- p.Arg248Cys Single submitter ⚠
- p.Arg255Gln Single submitter ⚠
- p.Arg255Trp Single submitter ⚠
- p.Arg25Gln Single submitter ⚠
- p.Arg313Cys Single submitter ⚠
- p.Arg348Cys Single submitter ⚠
- p.Arg348His Single submitter ⚠
- p.Arg385His Single submitter ⚠
- p.Arg470Gly Single submitter ⚠
- p.Arg470His Single submitter ⚠
- p.Arg471Ser Single submitter ⚠
- p.Arg475Gln Single submitter ⚠
- p.Arg475Pro Single submitter ⚠
- p.Arg510Cys Single submitter ⚠
- p.Arg540Gln Single submitter ⚠
- p.Asn186Ser Single submitter ⚠
- p.Asn302Ser Single submitter ⚠
- p.Asp192Asn Single submitter ⚠
- p.Asp194Tyr Single submitter ⚠
- p.Asp264Asn Single submitter ⚠
- p.Asp335His Single submitter ⚠
- p.Asp534Gly Single submitter ⚠
- p.Cys123Arg Single submitter ⚠
- p.Gln515His Single submitter ⚠
- p.Gln68Arg Single submitter ⚠
- p.Gln90Glu Single submitter ⚠
- p.Glu144Gln Single submitter ⚠
- p.Glu276Gly Single submitter ⚠
- p.Glu362Lys Single submitter ⚠
- p.Gly347Trp Single submitter ⚠
- p.Gly575Ser Single submitter ⚠
- p.His247Arg Single submitter ⚠
- p.His283Arg Single submitter ⚠
- p.Ile38Val Single submitter ⚠
- p.Ile390Val Single submitter ⚠
- p.Ile577Lys Single submitter ⚠
- p.Leu323Trp Single submitter ⚠
- p.Leu464Phe Single submitter ⚠
- p.Lys110Glu Single submitter ⚠
- p.Lys265Glu Single submitter ⚠
- p.Lys300Glu Single submitter ⚠
- p.Lys524Asn Single submitter ⚠
- p.Met239Ile Single submitter ⚠
- p.Met274Leu Single submitter ⚠
- p.Met422Val Single submitter ⚠
- p.Met570Thr Single submitter ⚠
- p.Met83Leu Single submitter ⚠
- p.Pro410Leu Single submitter ⚠
- p.Pro410Thr Single submitter ⚠
- p.Pro429Gln Single submitter ⚠
- p.Pro44Ala Single submitter ⚠
- p.Pro44Leu Single submitter ⚠
- p.Pro507Ala Single submitter ⚠
- p.Pro520Arg Single submitter ⚠
- p.Ser120Arg Single submitter ⚠
- p.Ser129Phe Single submitter ⚠
- p.Ser358Phe Single submitter ⚠
- p.Ser453Pro Single submitter ⚠
- p.Ser537Leu Single submitter ⚠
- p.Thr532Ile Single submitter ⚠
- p.Thr66Pro Single submitter ⚠
- p.Trp393Arg Single submitter ⚠
- p.Tyr451Cys Single submitter ⚠
- p.Val127Ile Single submitter ⚠
- p.Val559Leu Single submitter ⚠