DYRK4 — 72 ClinVar variants
All ClinVar germline DYRK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
5 Likely benign · 67 Uncertain significance
Full DYRK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DYRK4 p.Ala191Gly Uncertain significance Single submitter
- DYRK4 p.Ala269Thr Uncertain significance Single submitter
- DYRK4 p.Ala609Val Uncertain significance Single submitter
- DYRK4 p.Arg291His Uncertain significance Single submitter
- DYRK4 p.Arg448Thr Uncertain significance Single submitter
- DYRK4 p.Arg503Cys Uncertain significance Single submitter
- DYRK4 p.Arg503His Uncertain significance Single submitter
- DYRK4 p.Arg519Gln Uncertain significance Single submitter
- DYRK4 p.Asp473His Uncertain significance Single submitter
- DYRK4 p.Cys295Tyr Uncertain significance Single submitter
- DYRK4 p.Cys495Arg Uncertain significance Single submitter
- DYRK4 p.Cys549Tyr Uncertain significance Single submitter
- DYRK4 p.Gln147Pro Uncertain significance Single submitter
- DYRK4 p.Gly548Asp Uncertain significance Single submitter
- DYRK4 p.Gly608Arg Uncertain significance Single submitter
- DYRK4 p.His239Gln Uncertain significance Single submitter
- DYRK4 p.His512Asn Uncertain significance Single submitter
- DYRK4 p.His550Tyr Uncertain significance Single submitter
- DYRK4 p.Ile633Val Uncertain significance Single submitter
- DYRK4 p.Leu327Val Uncertain significance Single submitter
- DYRK4 p.Leu521Pro Uncertain significance Single submitter
- DYRK4 p.Lys138Glu Uncertain significance Single submitter
- DYRK4 p.Lys347Gln Uncertain significance Single submitter
- DYRK4 p.Lys565Thr Uncertain significance Single submitter
- DYRK4 p.Lys620Arg Uncertain significance Single submitter
- DYRK4 p.Lys625Arg Uncertain significance Single submitter
- DYRK4 p.Met284Ile Uncertain significance Single submitter
- DYRK4 p.Met479Ile Uncertain significance Single submitter
- DYRK4 p.Phe491Ser Uncertain significance Single submitter
- DYRK4 p.Pro127Ser Uncertain significance Single submitter
- DYRK4 p.Pro348Thr Uncertain significance Single submitter
- DYRK4 p.Pro525Ser Uncertain significance Single submitter
- DYRK4 p.Pro616Leu Uncertain significance Single submitter
- DYRK4 p.Ser382Cys Uncertain significance Single submitter
- DYRK4 p.Thr198Met Uncertain significance Single submitter
- DYRK4 p.Thr278Asn Uncertain significance Single submitter
- DYRK4 p.Thr445Ala Uncertain significance Single submitter
- DYRK4 p.Thr483Ile Uncertain significance Single submitter
- DYRK4 p.Tyr484Cys Uncertain significance Single submitter
- DYRK4 p.Val149Leu Uncertain significance Single submitter
- DYRK4 p.Val245Gly Uncertain significance Single submitter
- DYRK4 p.Val245Leu Uncertain significance Single submitter
- DYRK4 p.Val322Ala Uncertain significance Single submitter
- DYRK4 p.Val574Ile Uncertain significance Single submitter
- DYRK4 p.Val634Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- DYRK4 p.Ala153Val Uncertain significance Single submitter
- DYRK4 p.Ala176Val Uncertain significance Single submitter
- DYRK4 p.Arg255Ser Uncertain significance Single submitter
- DYRK4 p.Arg519Trp Uncertain significance Single submitter
- DYRK4 p.Asn304Asp Uncertain significance Single submitter
- DYRK4 p.Asn464Ser Uncertain significance Single submitter
- DYRK4 p.Asp286Asn Uncertain significance Single submitter
- DYRK4 p.Gln355Lys Uncertain significance Single submitter
- DYRK4 p.His373Arg Uncertain significance Single submitter
- DYRK4 p.Ile380Phe Uncertain significance Single submitter
- DYRK4 p.Leu418Val Uncertain significance Single submitter
- DYRK4 p.Leu435Val Uncertain significance Single submitter
- DYRK4 p.Leu437Arg Uncertain significance Single submitter
- DYRK4 p.Lys186Arg Uncertain significance Single submitter
- DYRK4 p.Lys468Thr Uncertain significance Single submitter
- DYRK4 p.Met402Ile Uncertain significance Single submitter
- DYRK4 p.Pro420Ser Uncertain significance Single submitter
- DYRK4 p.Ser369Gly Uncertain significance Single submitter
- DYRK4 p.Ser552Trp Uncertain significance Single submitter
- DYRK4 p.Thr152Ile Uncertain significance Single submitter
- DYRK4 p.Thr486Ile Uncertain significance Single submitter
- DYRK4 p.Val480Met Uncertain significance Single submitter
All DYRK4 variants
Likely benign 5
- p.Ala123Thr Single submitter
- p.Ala606Val Single submitter
- p.Pro117Leu Single submitter
- p.Val497= Single submitter
- p.Val629Ile Single submitter
Uncertain significance 67
- p.Ala153Val Single submitter ⚠
- p.Ala176Val Single submitter ⚠
- p.Ala191Gly Single submitter ⚠
- p.Ala269Thr Single submitter ⚠
- p.Ala609Val Single submitter ⚠
- p.Arg255Ser Single submitter ⚠
- p.Arg291His Single submitter ⚠
- p.Arg448Thr Single submitter ⚠
- p.Arg503Cys Single submitter ⚠
- p.Arg503His Single submitter ⚠
- p.Arg519Gln Single submitter ⚠
- p.Arg519Trp Single submitter ⚠
- p.Asn304Asp Single submitter ⚠
- p.Asn464Ser Single submitter ⚠
- p.Asp286Asn Single submitter ⚠
- p.Asp473His Single submitter ⚠
- p.Cys295Tyr Single submitter ⚠
- p.Cys495Arg Single submitter ⚠
- p.Cys549Tyr Single submitter ⚠
- p.Gln147Pro Single submitter ⚠
- p.Gln355Lys Single submitter ⚠
- p.Gly548Asp Single submitter ⚠
- p.Gly608Arg Single submitter ⚠
- p.His239Gln Single submitter ⚠
- p.His373Arg Single submitter ⚠
- p.His512Asn Single submitter ⚠
- p.His550Tyr Single submitter ⚠
- p.Ile380Phe Single submitter ⚠
- p.Ile633Val Single submitter ⚠
- p.Leu327Val Single submitter ⚠
- p.Leu418Val Single submitter ⚠
- p.Leu435Val Single submitter ⚠
- p.Leu437Arg Single submitter ⚠
- p.Leu521Pro Single submitter ⚠
- p.Lys138Glu Single submitter ⚠
- p.Lys186Arg Single submitter ⚠
- p.Lys347Gln Single submitter ⚠
- p.Lys468Thr Single submitter ⚠
- p.Lys565Thr Single submitter ⚠
- p.Lys620Arg Single submitter ⚠
- p.Lys625Arg Single submitter ⚠
- p.Met284Ile Single submitter ⚠
- p.Met402Ile Single submitter ⚠
- p.Met479Ile Single submitter ⚠
- p.Phe491Ser Single submitter ⚠
- p.Pro127Ser Single submitter ⚠
- p.Pro348Thr Single submitter ⚠
- p.Pro420Ser Single submitter ⚠
- p.Pro525Ser Single submitter ⚠
- p.Pro616Leu Single submitter ⚠
- p.Ser369Gly Single submitter ⚠
- p.Ser382Cys Single submitter ⚠
- p.Ser552Trp Single submitter ⚠
- p.Thr152Ile Single submitter ⚠
- p.Thr198Met Single submitter ⚠
- p.Thr278Asn Single submitter ⚠
- p.Thr445Ala Single submitter ⚠
- p.Thr483Ile Single submitter ⚠
- p.Thr486Ile Single submitter ⚠
- p.Tyr484Cys Single submitter ⚠
- p.Val149Leu Single submitter ⚠
- p.Val245Gly Single submitter ⚠
- p.Val245Leu Single submitter ⚠
- p.Val322Ala Single submitter ⚠
- p.Val480Met Single submitter ⚠
- p.Val574Ile Single submitter ⚠
- p.Val634Ile Single submitter ⚠