DYTN — 94 ClinVar variants
All ClinVar germline DYTN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →
11 Likely benign · 83 Uncertain significance
Full DYTN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 85
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DYTN p.Ala324Val Uncertain significance Single submitter
- DYTN p.Ala449Ser Uncertain significance Single submitter
- DYTN p.Ala465Thr Uncertain significance Single submitter
- DYTN p.Ala52Pro Uncertain significance Single submitter
- DYTN p.Ala564Thr Uncertain significance Single submitter
- DYTN p.Ala567Thr Uncertain significance Single submitter
- DYTN p.Ala573Pro Uncertain significance Single submitter
- DYTN p.Ala573Ser Uncertain significance Single submitter
- DYTN p.Arg170His Uncertain significance Single submitter
- DYTN p.Arg221Ser Uncertain significance Single submitter
- DYTN p.Arg227Gln Uncertain significance Single submitter
- DYTN p.Arg301Lys Uncertain significance Single submitter
- DYTN p.Arg353Gln Uncertain significance Single submitter
- DYTN p.Arg382Lys Uncertain significance Single submitter
- DYTN p.Asn364Ser Uncertain significance Single submitter
- DYTN p.Asn576Ser Uncertain significance Single submitter
- DYTN p.Cys252Phe Uncertain significance Single submitter
- DYTN p.Gln61Lys Uncertain significance Single submitter
- DYTN p.Gln6Lys Uncertain significance Single submitter
- DYTN p.Glu304Ala Uncertain significance Single submitter
- DYTN p.Glu68Asp Uncertain significance Single submitter
- DYTN p.Gly119Glu Uncertain significance Single submitter
- DYTN p.Gly139Arg Uncertain significance Single submitter
- DYTN p.Gly185Arg Uncertain significance Single submitter
- DYTN p.His323Gln Uncertain significance Single submitter
- DYTN p.His82Arg Uncertain significance Single submitter
- DYTN p.Ile115Val Uncertain significance Single submitter
- DYTN p.Ile16Met Uncertain significance Single submitter
- DYTN p.Ile272Thr Uncertain significance Single submitter
- DYTN p.Ile272Val Uncertain significance Single submitter
- DYTN p.Ile375Thr Uncertain significance Single submitter
- DYTN p.Leu257Ser Uncertain significance Single submitter
- DYTN p.Leu504Val Uncertain significance Single submitter
- DYTN p.Lys337Glu Uncertain significance Single submitter
- DYTN p.Lys407Gln Uncertain significance Single submitter
- DYTN p.Lys493Arg Uncertain significance Single submitter
- DYTN p.Met108Thr Uncertain significance Single submitter
- DYTN p.Met494Thr Uncertain significance Single submitter
- DYTN p.Met499Thr Uncertain significance Single submitter
- DYTN p.Phe288Ser Uncertain significance Single submitter
- DYTN p.Pro225Ser Uncertain significance Single submitter
- DYTN p.Pro385Ser Uncertain significance Single submitter
- DYTN p.Pro431Ser Uncertain significance Single submitter
- DYTN p.Pro546Leu Uncertain significance Single submitter
- DYTN p.Pro575Ser Uncertain significance Single submitter
- DYTN p.Ser264Cys Uncertain significance Single submitter
- DYTN p.Ser500Thr Uncertain significance Single submitter
- DYTN p.Ser532Pro Uncertain significance Single submitter
- DYTN p.Thr157Arg Uncertain significance Single submitter
- DYTN p.Thr94Arg Uncertain significance Single submitter
- DYTN p.Trp199Cys Uncertain significance Single submitter
- DYTN p.Trp369Arg Uncertain significance Single submitter
- DYTN p.Tyr241His Uncertain significance Single submitter
- DYTN p.Val151Leu Uncertain significance Single submitter
- DYTN p.Val166Met Uncertain significance Single submitter
- DYTN p.Val408Ile Uncertain significance Single submitter
- DYTN p.Gln470Lys Uncertain significance No assertion criteria
Predictors split 28
The independent predictors disagree with each other — read with care.
- DYTN p.Ala112Thr Uncertain significance Single submitter
- DYTN p.Ala178Val Uncertain significance Single submitter
- DYTN p.Arg146His Uncertain significance Single submitter
- DYTN p.Arg215Gln Uncertain significance Single submitter
- DYTN p.Arg232Ser Uncertain significance Single submitter
- DYTN p.Arg242His Uncertain significance Single submitter
- DYTN p.Arg301Gly Uncertain significance Single submitter
- DYTN p.Cys246Tyr Uncertain significance Single submitter
- DYTN p.Gln253Arg Uncertain significance Single submitter
- DYTN p.Gln253His Uncertain significance Single submitter
- DYTN p.Gln31Arg Uncertain significance Single submitter
- DYTN p.Glu176Gln Uncertain significance Single submitter
- DYTN p.Glu273Val Uncertain significance Single submitter
- DYTN p.Glu523Val Uncertain significance Single submitter
- DYTN p.Gly79Ala Uncertain significance Single submitter
- DYTN p.Gly79Glu Uncertain significance Single submitter
- DYTN p.His214Tyr Likely benign Single submitter
- DYTN p.Leu105Phe Uncertain significance Single submitter
- DYTN p.Leu287Pro Uncertain significance Single submitter
- DYTN p.Leu328Pro Uncertain significance Single submitter
- DYTN p.Lys302Thr Uncertain significance Single submitter
- DYTN p.Pro270Ala Uncertain significance Single submitter
- DYTN p.Pro86Leu Uncertain significance Single submitter
- DYTN p.Ser11Gly Uncertain significance Single submitter
- DYTN p.Ser137Asn Likely benign Single submitter
- DYTN p.Ser202Pro Uncertain significance Single submitter
- DYTN p.Ser482Asn Uncertain significance Single submitter
- DYTN p.Val175Gly Uncertain significance Single submitter
All DYTN variants
Likely benign 11
- p.Ala110= Single submitter
- p.Ala324= Single submitter
- p.Ala449Val Single submitter
- p.Arg377Gln Single submitter
- p.Arg46His Single submitter
- p.Gln282Glu Single submitter
- p.His214Tyr Single submitter ⚠
- p.Leu208= Single submitter
- p.Ser137Asn Single submitter ⚠
- p.Thr405Ala Single submitter
- p.Thr426Arg Single submitter
Uncertain significance 83
- p.Ala112Thr Single submitter ⚠
- p.Ala178Val Single submitter ⚠
- p.Ala324Val Single submitter ⚠
- p.Ala449Ser Single submitter ⚠
- p.Ala465Thr Single submitter ⚠
- p.Ala52Pro Single submitter ⚠
- p.Ala564Thr Single submitter ⚠
- p.Ala567Thr Single submitter ⚠
- p.Ala573Pro Single submitter ⚠
- p.Ala573Ser Single submitter ⚠
- p.Arg146His Single submitter ⚠
- p.Arg170His Single submitter ⚠
- p.Arg215Gln Single submitter ⚠
- p.Arg221Ser Single submitter ⚠
- p.Arg227Gln Single submitter ⚠
- p.Arg232Ser Single submitter ⚠
- p.Arg242His Single submitter ⚠
- p.Arg301Gly Single submitter ⚠
- p.Arg301Lys Single submitter ⚠
- p.Arg353Gln Single submitter ⚠
- p.Arg382Lys Single submitter ⚠
- p.Asn364Ser Single submitter ⚠
- p.Asn576Ser Single submitter ⚠
- p.Cys246Tyr Single submitter ⚠
- p.Cys252Phe Single submitter ⚠
- p.Gln253Arg Single submitter ⚠
- p.Gln253His Single submitter ⚠
- p.Gln31Arg Single submitter ⚠
- p.Gln61Lys Single submitter ⚠
- p.Gln6Lys Single submitter ⚠
- p.Glu176Gln Single submitter ⚠
- p.Glu273Val Single submitter ⚠
- p.Glu304Ala Single submitter ⚠
- p.Glu523Val Single submitter ⚠
- p.Glu68Asp Single submitter ⚠
- p.Gly119Glu Single submitter ⚠
- p.Gly139Arg Single submitter ⚠
- p.Gly185Arg Single submitter ⚠
- p.Gly79Ala Single submitter ⚠
- p.Gly79Glu Single submitter ⚠
- p.His323Gln Single submitter ⚠
- p.His82Arg Single submitter ⚠
- p.Ile115Val Single submitter ⚠
- p.Ile16Met Single submitter ⚠
- p.Ile272Thr Single submitter ⚠
- p.Ile272Val Single submitter ⚠
- p.Ile375Thr Single submitter ⚠
- p.Leu105Phe Single submitter ⚠
- p.Leu257Ser Single submitter ⚠
- p.Leu287Pro Single submitter ⚠
- p.Leu328Pro Single submitter ⚠
- p.Leu504Val Single submitter ⚠
- p.Lys302Thr Single submitter ⚠
- p.Lys337Glu Single submitter ⚠
- p.Lys407Gln Single submitter ⚠
- p.Lys493Arg Single submitter ⚠
- p.Met108Thr Single submitter ⚠
- p.Met494Thr Single submitter ⚠
- p.Met499Thr Single submitter ⚠
- p.Phe288Ser Single submitter ⚠
- p.Pro225Ser Single submitter ⚠
- p.Pro270Ala Single submitter ⚠
- p.Pro385Ser Single submitter ⚠
- p.Pro431Ser Single submitter ⚠
- p.Pro546Leu Single submitter ⚠
- p.Pro575Ser Single submitter ⚠
- p.Pro86Leu Single submitter ⚠
- p.Ser11Gly Single submitter ⚠
- p.Ser202Pro Single submitter ⚠
- p.Ser264Cys Single submitter ⚠
- p.Ser482Asn Single submitter ⚠
- p.Ser500Thr Single submitter ⚠
- p.Ser532Pro Single submitter ⚠
- p.Thr157Arg Single submitter ⚠
- p.Thr94Arg Single submitter ⚠
- p.Trp199Cys Single submitter ⚠
- p.Trp369Arg Single submitter ⚠
- p.Tyr241His Single submitter ⚠
- p.Val151Leu Single submitter ⚠
- p.Val166Met Single submitter ⚠
- p.Val175Gly Single submitter ⚠
- p.Val408Ile Single submitter ⚠
- p.Gln470Lys No assertion criteria ⚠