DZANK1 — 112 ClinVar variants
All ClinVar germline DZANK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →
5 Likely benign · 107 Uncertain significance
Full DZANK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 104
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 93
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DZANK1 p.Ala185Pro Uncertain significance Single submitter
- DZANK1 p.Ala205Val Uncertain significance Single submitter
- DZANK1 p.Ala301Thr Uncertain significance Single submitter
- DZANK1 p.Ala331Asp Uncertain significance Single submitter
- DZANK1 p.Ala681Val Uncertain significance Single submitter
- DZANK1 p.Ala767Pro Uncertain significance Single submitter
- DZANK1 p.Arg193Lys Uncertain significance Single submitter
- DZANK1 p.Arg237Gly Uncertain significance Single submitter
- DZANK1 p.Arg260Cys Uncertain significance Single submitter
- DZANK1 p.Arg260His Uncertain significance Single submitter
- DZANK1 p.Arg312Gln Uncertain significance Single submitter
- DZANK1 p.Arg527Trp Uncertain significance Single submitter
- DZANK1 p.Arg611Lys Uncertain significance Single submitter
- DZANK1 p.Asn143Asp Uncertain significance Single submitter
- DZANK1 p.Asn23Ser Uncertain significance Single submitter
- DZANK1 p.Asn561Asp Uncertain significance Single submitter
- DZANK1 p.Asn64Asp Uncertain significance Single submitter
- DZANK1 p.Asp103Asn Uncertain significance Single submitter
- DZANK1 p.Asp226Gly Uncertain significance Single submitter
- DZANK1 p.Asp449Asn Uncertain significance Single submitter
- DZANK1 p.Asp574Asn Uncertain significance Single submitter
- DZANK1 p.Asp574Gly Uncertain significance Single submitter
- DZANK1 p.Asp748Tyr Uncertain significance Single submitter
- DZANK1 p.Asp764Glu Uncertain significance Single submitter
- DZANK1 p.Asp775His Uncertain significance Single submitter
- DZANK1 p.Cys311Tyr Uncertain significance Single submitter
- DZANK1 p.Cys340Ser Uncertain significance Single submitter
- DZANK1 p.Cys408Trp Uncertain significance Single submitter
- DZANK1 p.Gln126Glu Uncertain significance Single submitter
- DZANK1 p.Gln247Pro Uncertain significance Single submitter
- DZANK1 p.Gln336Leu Uncertain significance Single submitter
- DZANK1 p.Gln687Arg Uncertain significance Single submitter
- DZANK1 p.Glu113Gly Uncertain significance Single submitter
- DZANK1 p.Glu427Gln Uncertain significance Single submitter
- DZANK1 p.Gly131Glu Uncertain significance Single submitter
- DZANK1 p.Gly134Glu Uncertain significance Single submitter
- DZANK1 p.Gly209Ser Uncertain significance Single submitter
- DZANK1 p.Gly353Ala Uncertain significance Single submitter
- DZANK1 p.Gly353Val Uncertain significance Single submitter
- DZANK1 p.Gly362Asp Uncertain significance Single submitter
- DZANK1 p.Gly457Glu Uncertain significance Single submitter
- DZANK1 p.Gly61Val Uncertain significance Single submitter
- DZANK1 p.His206Arg Uncertain significance Single submitter
- DZANK1 p.His575Gln Uncertain significance Single submitter
- DZANK1 p.His705Arg Uncertain significance Single submitter
- DZANK1 p.Ile256Val Uncertain significance Single submitter
- DZANK1 p.Ile456Lys Uncertain significance Single submitter
- DZANK1 p.Ile552Asn Uncertain significance Single submitter
- DZANK1 p.Ile58Asn Uncertain significance Single submitter
- DZANK1 p.Ile728Thr Uncertain significance Single submitter
- DZANK1 p.Ile95Val Uncertain significance Single submitter
- DZANK1 p.Leu234Phe Uncertain significance Single submitter
- DZANK1 p.Leu293Phe Uncertain significance Single submitter
- DZANK1 p.Leu303His Uncertain significance Single submitter
- DZANK1 p.Leu423Pro Uncertain significance Single submitter
- DZANK1 p.Leu423Val Uncertain significance Single submitter
- DZANK1 p.Leu699Val Uncertain significance Single submitter
- DZANK1 p.Leu710Pro Uncertain significance Single submitter
- DZANK1 p.Leu749Val Uncertain significance Single submitter
- DZANK1 p.Lys469Arg Uncertain significance Single submitter
- DZANK1 p.Lys636Glu Uncertain significance Single submitter
- DZANK1 p.Lys67Glu Uncertain significance Single submitter
- DZANK1 p.Met281Arg Uncertain significance Single submitter
- DZANK1 p.Met339Thr Uncertain significance Single submitter
- DZANK1 p.Met488Ile Uncertain significance Single submitter
- DZANK1 p.Met675Arg Uncertain significance Single submitter
- DZANK1 p.Pro13Leu Uncertain significance Single submitter
- DZANK1 p.Pro158Thr Uncertain significance Single submitter
- DZANK1 p.Pro195Ser Uncertain significance Single submitter
- DZANK1 p.Pro347Ser Uncertain significance Single submitter
- DZANK1 p.Pro39Leu Uncertain significance Single submitter
- DZANK1 p.Pro444Leu Uncertain significance Single submitter
- DZANK1 p.Ser111Cys Uncertain significance Single submitter
- DZANK1 p.Ser149Asn Uncertain significance Single submitter
- DZANK1 p.Ser201Tyr Uncertain significance Single submitter
- DZANK1 p.Ser251Phe Uncertain significance Single submitter
- DZANK1 p.Ser411Thr Uncertain significance Single submitter
- DZANK1 p.Ser416Asn Uncertain significance Single submitter
- DZANK1 p.Ser440Phe Uncertain significance Single submitter
- DZANK1 p.Ser573Arg Uncertain significance Single submitter
- DZANK1 p.Ser573Gly Uncertain significance Single submitter
- DZANK1 p.Ser596Gly Uncertain significance Single submitter
- DZANK1 p.Ser601Asn Uncertain significance Single submitter
- DZANK1 p.Ser727Asn Uncertain significance Single submitter
- DZANK1 p.Thr641Met Uncertain significance Single submitter
- DZANK1 p.Thr745Ile Uncertain significance Single submitter
- DZANK1 p.Tyr104Cys Uncertain significance Single submitter
- DZANK1 p.Tyr324Cys Uncertain significance Single submitter
- DZANK1 p.Tyr519Phe Uncertain significance Single submitter
- DZANK1 p.Val287Met Uncertain significance Single submitter
- DZANK1 p.Val461Ala Uncertain significance Single submitter
- DZANK1 p.Val669Ile Uncertain significance Single submitter
- DZANK1 p.Val96Leu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- DZANK1 p.Ala497Asp Uncertain significance Multiple submitters
- DZANK1 p.Ala291Pro Uncertain significance Single submitter
- DZANK1 p.Ala719Pro Uncertain significance Single submitter
- DZANK1 p.Ala742Ser Uncertain significance Single submitter
- DZANK1 p.Arg15Gln Uncertain significance Single submitter
- DZANK1 p.Asn522Lys Uncertain significance Single submitter
- DZANK1 p.Gln92Arg Uncertain significance Single submitter
- DZANK1 p.Gly4Val Uncertain significance Single submitter
- DZANK1 p.Leu699Pro Uncertain significance Single submitter
- DZANK1 p.Thr496Ile Uncertain significance Single submitter
- DZANK1 p.Val41Phe Uncertain significance Single submitter
All DZANK1 variants
Likely benign 5
- p.Ala580Val Single submitter
- p.Arg125Lys Single submitter
- p.Leu417Met Single submitter
- p.Val207Ile Single submitter
- p.Val450Ala Single submitter
Uncertain significance 107
- p.Ala497Asp Multiple submitters ⚠
- p.Ala185Pro Single submitter ⚠
- p.Ala205Val Single submitter ⚠
- p.Ala291Pro Single submitter ⚠
- p.Ala301Thr Single submitter ⚠
- p.Ala331Asp Single submitter ⚠
- p.Ala681Val Single submitter ⚠
- p.Ala719Pro Single submitter ⚠
- p.Ala742Ser Single submitter ⚠
- p.Ala767Pro Single submitter ⚠
- p.Arg15Gln Single submitter ⚠
- p.Arg193Lys Single submitter ⚠
- p.Arg237Gly Single submitter ⚠
- p.Arg237Trp Single submitter
- p.Arg260Cys Single submitter ⚠
- p.Arg260His Single submitter ⚠
- p.Arg312Gln Single submitter ⚠
- p.Arg527Trp Single submitter ⚠
- p.Arg611Lys Single submitter ⚠
- p.Asn143Asp Single submitter ⚠
- p.Asn23Ser Single submitter ⚠
- p.Asn522Lys Single submitter ⚠
- p.Asn561Asp Single submitter ⚠
- p.Asn64Asp Single submitter ⚠
- p.Asp103Asn Single submitter ⚠
- p.Asp226Gly Single submitter ⚠
- p.Asp449Asn Single submitter ⚠
- p.Asp574Asn Single submitter ⚠
- p.Asp574Gly Single submitter ⚠
- p.Asp658Glu Single submitter
- p.Asp748Tyr Single submitter ⚠
- p.Asp764Glu Single submitter ⚠
- p.Asp775His Single submitter ⚠
- p.Cys311Tyr Single submitter ⚠
- p.Cys340Ser Single submitter ⚠
- p.Cys408Trp Single submitter ⚠
- p.Gln126Glu Single submitter ⚠
- p.Gln247Pro Single submitter ⚠
- p.Gln336Leu Single submitter ⚠
- p.Gln687Arg Single submitter ⚠
- p.Gln92Arg Single submitter ⚠
- p.Glu113Gly Single submitter ⚠
- p.Glu427Gln Single submitter ⚠
- p.Gly131Glu Single submitter ⚠
- p.Gly134Glu Single submitter ⚠
- p.Gly209Ser Single submitter ⚠
- p.Gly353Ala Single submitter ⚠
- p.Gly353Val Single submitter ⚠
- p.Gly362Asp Single submitter ⚠
- p.Gly457Glu Single submitter ⚠
- p.Gly4Val Single submitter ⚠
- p.Gly59Asp Single submitter
- p.Gly61Val Single submitter ⚠
- p.His206Arg Single submitter ⚠
- p.His575Gln Single submitter ⚠
- p.His705Arg Single submitter ⚠
- p.Ile256Val Single submitter ⚠
- p.Ile456Lys Single submitter ⚠
- p.Ile552Asn Single submitter ⚠
- p.Ile58Asn Single submitter ⚠
- p.Ile728Thr Single submitter ⚠
- p.Ile95Val Single submitter ⚠
- p.Leu234Phe Single submitter ⚠
- p.Leu293Phe Single submitter ⚠
- p.Leu303His Single submitter ⚠
- p.Leu423Pro Single submitter ⚠
- p.Leu423Val Single submitter ⚠
- p.Leu699Pro Single submitter ⚠
- p.Leu699Val Single submitter ⚠
- p.Leu710Pro Single submitter ⚠
- p.Leu749Val Single submitter ⚠
- p.Lys469Arg Single submitter ⚠
- p.Lys636Glu Single submitter ⚠
- p.Lys67Glu Single submitter ⚠
- p.Met281Arg Single submitter ⚠
- p.Met339Thr Single submitter ⚠
- p.Met488Ile Single submitter ⚠
- p.Met675Arg Single submitter ⚠
- p.Pro13Leu Single submitter ⚠
- p.Pro158Thr Single submitter ⚠
- p.Pro195Ser Single submitter ⚠
- p.Pro347Ser Single submitter ⚠
- p.Pro39Leu Single submitter ⚠
- p.Pro444Leu Single submitter ⚠
- p.Ser111Cys Single submitter ⚠
- p.Ser149Asn Single submitter ⚠
- p.Ser201Tyr Single submitter ⚠
- p.Ser251Phe Single submitter ⚠
- p.Ser411Thr Single submitter ⚠
- p.Ser416Asn Single submitter ⚠
- p.Ser440Phe Single submitter ⚠
- p.Ser573Arg Single submitter ⚠
- p.Ser573Gly Single submitter ⚠
- p.Ser596Gly Single submitter ⚠
- p.Ser601Asn Single submitter ⚠
- p.Ser727Asn Single submitter ⚠
- p.Thr496Ile Single submitter ⚠
- p.Thr641Met Single submitter ⚠
- p.Thr745Ile Single submitter ⚠
- p.Tyr104Cys Single submitter ⚠
- p.Tyr324Cys Single submitter ⚠
- p.Tyr519Phe Single submitter ⚠
- p.Val287Met Single submitter ⚠
- p.Val41Phe Single submitter ⚠
- p.Val461Ala Single submitter ⚠
- p.Val669Ile Single submitter ⚠
- p.Val96Leu Single submitter ⚠