DZIP3 — 148 ClinVar variants

All ClinVar germline DZIP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 141 flagged for review →

2 Benign · 5 Likely benign · 141 Uncertain significance

Full DZIP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 141

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 99

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 42

The independent predictors disagree with each other — read with care.

All DZIP3 variants

Benign 2

c.456+10A>G Multiple submitters
p.Asp6Gly Multiple submitters

Likely benign 5

p.Ala1063Thr Single submitter
p.Ala917Thr Single submitter
p.Ile702Met Single submitter
p.Leu1011Val Single submitter
p.Val849Ile Single submitter

Uncertain significance 141

p.Ala1018Ser Single submitter ⚠
p.Ala114Val Single submitter ⚠
p.Ala14Thr Single submitter ⚠
p.Ala714Thr Single submitter ⚠
p.Ala793Thr Single submitter ⚠
p.Ala854Thr Single submitter ⚠
p.Arg106His Single submitter ⚠
p.Arg1203Trp Single submitter ⚠
p.Arg148Lys Single submitter ⚠
p.Arg185His Single submitter ⚠
p.Arg189Gln Single submitter ⚠
p.Arg19Lys Single submitter ⚠
p.Arg259Gln Single submitter ⚠
p.Arg409Gln Single submitter ⚠
p.Arg539Cys Single submitter ⚠
p.Arg539His Single submitter ⚠
p.Arg753His Single submitter ⚠
p.Arg755Ser Single submitter ⚠
p.Arg777Trp Single submitter ⚠
p.Arg870His Single submitter ⚠
p.Arg871Ser Single submitter ⚠
p.Asn176Tyr Single submitter ⚠
p.Asn796Lys Single submitter ⚠
p.Asn921Lys Single submitter ⚠
p.Asp153Tyr Single submitter ⚠
p.Asp256His Single submitter ⚠
p.Asp264Asn Single submitter ⚠
p.Asp368Asn Single submitter ⚠
p.Asp510Gly Single submitter ⚠
p.Asp561Glu Single submitter ⚠
p.Asp6Ala Single submitter ⚠
p.Asp708Asn Single submitter ⚠
p.Asp910Tyr Single submitter ⚠
p.Cys1173Phe Single submitter ⚠
p.Cys764Tyr Single submitter ⚠
p.Gln1127Arg Single submitter ⚠
p.Gln18Glu Single submitter ⚠
p.Gln677His Single submitter ⚠
p.Gln756His Single submitter ⚠
p.Gln77Lys Single submitter ⚠
p.Gln810Arg Single submitter ⚠
p.Gln868Arg Single submitter ⚠
p.Gln880Arg Single submitter ⚠
p.Glu1035Asp Single submitter ⚠
p.Glu1035Gly Single submitter ⚠
p.Glu1052Asp Single submitter ⚠
p.Glu156Asp Single submitter ⚠
p.Glu16Gly Single submitter ⚠
p.Glu170Gly Single submitter ⚠
p.Glu21Gly Single submitter ⚠
p.Glu316Lys Single submitter ⚠
p.Glu382Gly Single submitter ⚠
p.Glu433Lys Single submitter ⚠
p.Glu552Asp Single submitter ⚠
p.Glu835Lys Single submitter ⚠
p.Glu855Gly Single submitter ⚠
p.Gly132Cys Single submitter ⚠
p.Gly186Ser Single submitter ⚠
p.Gly210Ala Single submitter ⚠
p.Gly744Val Single submitter ⚠
p.His1152Gln Single submitter ⚠
p.His428Tyr Single submitter ⚠
p.His761Asp Single submitter ⚠
p.His877Pro Single submitter ⚠
p.Ile1031Thr Single submitter ⚠
p.Ile1031Val Single submitter ⚠
p.Ile173Val Single submitter ⚠
p.Ile219Val Single submitter ⚠
p.Ile349Asn Single submitter ⚠
p.Ile349Thr Single submitter ⚠
p.Ile369Thr Single submitter ⚠
p.Ile411Val Single submitter ⚠
p.Ile502Thr Single submitter ⚠
p.Ile547Ser Single submitter ⚠
p.Ile601Thr Single submitter ⚠
p.Ile923Val Single submitter ⚠
p.Ile99Thr Single submitter ⚠
p.Leu227Ile Single submitter ⚠
p.Leu255Arg Single submitter ⚠
p.Leu420Pro Single submitter ⚠
p.Leu451Val Single submitter ⚠
p.Leu538Pro Single submitter ⚠
p.Leu886Val Single submitter ⚠
p.Leu966Phe Single submitter ⚠
p.Lys1079Asn Single submitter ⚠
p.Lys1088Met Single submitter ⚠
p.Lys267Asn Single submitter ⚠
p.Lys289Ile Single submitter ⚠
p.Lys635Thr Single submitter ⚠
p.Lys684Glu Single submitter ⚠
p.Lys938Arg Single submitter ⚠
p.Met164Leu Single submitter ⚠
p.Met278Thr Single submitter ⚠
p.Met489Arg Single submitter ⚠
p.Met543Leu Single submitter ⚠
p.Met580Leu Single submitter ⚠
p.Met829Val Single submitter ⚠
p.Met962Val Single submitter ⚠
p.Met985Thr Single submitter ⚠
p.Phe377Cys Single submitter ⚠
p.Phe412Val Single submitter ⚠
p.Phe630Cys Single submitter ⚠
p.Pro1104Ser Single submitter ⚠
p.Pro1201Ala Single submitter ⚠
p.Pro221Ser Single submitter ⚠
p.Pro301Ala Single submitter ⚠
p.Pro492Leu Single submitter ⚠
p.Pro969Leu Single submitter ⚠
p.Ser244Asn Single submitter ⚠
p.Ser499Pro Single submitter ⚠
p.Ser596Arg Single submitter ⚠
p.Ser721Thr Single submitter ⚠
p.Ser735Leu Single submitter ⚠
p.Ser81Cys Single submitter ⚠
p.Ser81Phe Single submitter ⚠
p.Ser843Asn Single submitter ⚠
p.Ser93Gly Single submitter ⚠
p.Thr1125Ile Single submitter ⚠
p.Thr250Arg Single submitter ⚠
p.Thr250Met Single submitter ⚠
p.Thr405Ala Single submitter ⚠
p.Thr847Ile Single submitter ⚠
p.Thr945Ile Single submitter ⚠
p.Tyr271Cys Single submitter ⚠
p.Tyr300Cys Single submitter ⚠
p.Tyr453His Single submitter ⚠
p.Tyr568Cys Single submitter ⚠
p.Tyr680Cys Single submitter ⚠
p.Tyr762Cys Single submitter ⚠
p.Tyr848His Single submitter ⚠
p.Val1077Gly Single submitter ⚠
p.Val1102Ala Single submitter ⚠
p.Val323Leu Single submitter ⚠
p.Val330Ala Single submitter ⚠
p.Val341Leu Single submitter ⚠
p.Val431Met Single submitter ⚠
p.Val698Leu Single submitter ⚠
p.Val806Phe Single submitter ⚠
p.Val864Ala Single submitter ⚠
p.Val892Leu Single submitter ⚠
p.Val988Ile Single submitter ⚠