E2F2 — 61 ClinVar variants
All ClinVar germline E2F2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
1 Benign · 3 Likely benign · 57 Uncertain significance
Full E2F2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- E2F2 p.Ala158Thr Uncertain significance Single submitter
- E2F2 p.Ala21Val Uncertain significance Single submitter
- E2F2 p.Ala223Val Uncertain significance Single submitter
- E2F2 p.Ala395Val Uncertain significance Single submitter
- E2F2 p.Ala40Gly Uncertain significance Single submitter
- E2F2 p.Ala40Val Uncertain significance Single submitter
- E2F2 p.Ala58Val Uncertain significance Single submitter
- E2F2 p.Ala7Pro Uncertain significance Single submitter
- E2F2 p.Asp154Asn Uncertain significance Single submitter
- E2F2 p.Asp424Gly Uncertain significance Single submitter
- E2F2 p.Cys325Arg Uncertain significance Single submitter
- E2F2 p.Gln357Glu Uncertain significance Single submitter
- E2F2 p.Glu147Lys Uncertain significance Single submitter
- E2F2 p.Gly13Arg Uncertain significance Single submitter
- E2F2 p.Gly296Glu Uncertain significance Single submitter
- E2F2 p.His379Tyr Uncertain significance Single submitter
- E2F2 p.Ile142Val Uncertain significance Single submitter
- E2F2 p.Ile94Thr Uncertain significance Single submitter
- E2F2 p.Lys119Arg Uncertain significance Single submitter
- E2F2 p.Lys206Glu Uncertain significance Single submitter
- E2F2 p.Lys270Glu Uncertain significance Single submitter
- E2F2 p.Phe403Cys Uncertain significance Single submitter
- E2F2 p.Pro24Leu Uncertain significance Single submitter
- E2F2 p.Pro356Leu Uncertain significance Single submitter
- E2F2 p.Pro362Leu Uncertain significance Single submitter
- E2F2 p.Pro54Ser Uncertain significance Single submitter
- E2F2 p.Pro5Ser Uncertain significance Single submitter
- E2F2 p.Ser312Arg Uncertain significance Single submitter
- E2F2 p.Ser312Gly Uncertain significance Single submitter
- E2F2 p.Ser348Leu Uncertain significance Single submitter
- E2F2 p.Tyr130Cys Uncertain significance Single submitter
- E2F2 p.Val266Ala Uncertain significance Single submitter
- E2F2 p.Val99Ile Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- E2F2 p.Thr202Ile Likely benign Multiple submitters
- E2F2 p.Arg183Cys Uncertain significance Single submitter
- E2F2 p.Arg183His Uncertain significance Single submitter
- E2F2 p.Arg246Gly Uncertain significance Single submitter
- E2F2 p.Arg256Cys Uncertain significance Single submitter
- E2F2 p.Asn244Ser Uncertain significance Single submitter
- E2F2 p.Asp285Gly Uncertain significance Single submitter
- E2F2 p.Ile289Met Uncertain significance Single submitter
- E2F2 p.Leu48Met Uncertain significance Single submitter
- E2F2 p.Pro16Thr Uncertain significance Single submitter
- E2F2 p.Pro280Ala Uncertain significance Single submitter
- E2F2 p.Pro319Leu Uncertain significance Single submitter
- E2F2 p.Pro333Leu Uncertain significance Single submitter
- E2F2 p.Pro392Leu Uncertain significance Single submitter
- E2F2 p.Pro79Arg Uncertain significance Single submitter
- E2F2 p.Pro79Gln Uncertain significance Single submitter
- E2F2 p.Pro79Leu Uncertain significance Single submitter
- E2F2 p.Ser117Ile Uncertain significance Single submitter
- E2F2 p.Ser334Asn Uncertain significance Single submitter
- E2F2 p.Ser340Asn Uncertain significance Single submitter
- E2F2 p.Thr104Ala Uncertain significance Single submitter
- E2F2 p.Thr294Ala Uncertain significance Single submitter
- E2F2 p.Thr345Ile Uncertain significance Single submitter
- E2F2 p.Val307Met Uncertain significance Single submitter
- E2F2 p.Val98Ile Uncertain significance Single submitter
All E2F2 variants
Benign 1
- p.Pro310Leu Multiple submitters
Likely benign 3
- p.Thr202Ile Multiple submitters ⚠
- p.Ile298= Single submitter
- p.Thr265= Single submitter
Uncertain significance 57
- p.Ala158Thr Single submitter ⚠
- p.Ala21Val Single submitter ⚠
- p.Ala223Val Single submitter ⚠
- p.Ala395Val Single submitter ⚠
- p.Ala40Gly Single submitter ⚠
- p.Ala40Val Single submitter ⚠
- p.Ala58Val Single submitter ⚠
- p.Ala7Pro Single submitter ⚠
- p.Arg183Cys Single submitter ⚠
- p.Arg183His Single submitter ⚠
- p.Arg246Gly Single submitter ⚠
- p.Arg256Cys Single submitter ⚠
- p.Asn244Ser Single submitter ⚠
- p.Asp154Asn Single submitter ⚠
- p.Asp285Gly Single submitter ⚠
- p.Asp424Gly Single submitter ⚠
- p.Cys325Arg Single submitter ⚠
- p.Gln357Glu Single submitter ⚠
- p.Glu147Lys Single submitter ⚠
- p.Gly13Arg Single submitter ⚠
- p.Gly296Glu Single submitter ⚠
- p.His379Tyr Single submitter ⚠
- p.Ile142Val Single submitter ⚠
- p.Ile289Met Single submitter ⚠
- p.Ile94Thr Single submitter ⚠
- p.Leu48Met Single submitter ⚠
- p.Lys119Arg Single submitter ⚠
- p.Lys206Glu Single submitter ⚠
- p.Lys270Glu Single submitter ⚠
- p.Phe403Cys Single submitter ⚠
- p.Pro16Thr Single submitter ⚠
- p.Pro24Leu Single submitter ⚠
- p.Pro280Ala Single submitter ⚠
- p.Pro319Leu Single submitter ⚠
- p.Pro333Leu Single submitter ⚠
- p.Pro356Leu Single submitter ⚠
- p.Pro362Leu Single submitter ⚠
- p.Pro392Leu Single submitter ⚠
- p.Pro54Ser Single submitter ⚠
- p.Pro5Ser Single submitter ⚠
- p.Pro79Arg Single submitter ⚠
- p.Pro79Gln Single submitter ⚠
- p.Pro79Leu Single submitter ⚠
- p.Ser117Ile Single submitter ⚠
- p.Ser312Arg Single submitter ⚠
- p.Ser312Gly Single submitter ⚠
- p.Ser334Asn Single submitter ⚠
- p.Ser340Asn Single submitter ⚠
- p.Ser348Leu Single submitter ⚠
- p.Thr104Ala Single submitter ⚠
- p.Thr294Ala Single submitter ⚠
- p.Thr345Ile Single submitter ⚠
- p.Tyr130Cys Single submitter ⚠
- p.Val266Ala Single submitter ⚠
- p.Val307Met Single submitter ⚠
- p.Val98Ile Single submitter ⚠
- p.Val99Ile Single submitter ⚠