E2F5 — 48 ClinVar variants
All ClinVar germline E2F5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
1 Likely benign · 47 Uncertain significance
Full E2F5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- E2F5 p.Ala192Ser Uncertain significance Single submitter
- E2F5 p.Ala295Glu Uncertain significance Single submitter
- E2F5 p.Asn183Lys Uncertain significance Single submitter
- E2F5 p.Asp324Asn Uncertain significance Single submitter
- E2F5 p.Asp81Ala Uncertain significance Single submitter
- E2F5 p.Asp81Val Uncertain significance Single submitter
- E2F5 p.Gln11Pro Uncertain significance Single submitter
- E2F5 p.Gln156His Uncertain significance Single submitter
- E2F5 p.Gln285Lys Uncertain significance Single submitter
- E2F5 p.Gln286Arg Uncertain significance Single submitter
- E2F5 p.Gly42Arg Uncertain significance Single submitter
- E2F5 p.Gly47Ser Uncertain significance Single submitter
- E2F5 p.His276Pro Uncertain significance Single submitter
- E2F5 p.Ile104Leu Uncertain significance Single submitter
- E2F5 p.Ile112Val Uncertain significance Single submitter
- E2F5 p.Ile127Met Uncertain significance Single submitter
- E2F5 p.Ile229Val Uncertain significance Single submitter
- E2F5 p.Leu249Phe Uncertain significance Single submitter
- E2F5 p.Ser157Asn Uncertain significance Single submitter
- E2F5 p.Thr196Ile Uncertain significance Single submitter
- E2F5 p.Thr269Pro Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- E2F5 p.Ala44Thr Uncertain significance Single submitter
- E2F5 p.Ala44Val Uncertain significance Single submitter
- E2F5 p.Ala78Glu Uncertain significance Single submitter
- E2F5 p.Asp163Gly Uncertain significance Single submitter
- E2F5 p.Asp177Glu Uncertain significance Single submitter
- E2F5 p.Asp301Glu Uncertain significance Single submitter
- E2F5 p.Asp301Gly Uncertain significance Single submitter
- E2F5 p.Asp71Asn Uncertain significance Single submitter
- E2F5 p.Asp81Glu Uncertain significance Single submitter
- E2F5 p.Gln197Glu Uncertain significance Single submitter
- E2F5 p.Gln207His Uncertain significance Single submitter
- E2F5 p.Gln31Arg Uncertain significance Single submitter
- E2F5 p.Glu232Gln Uncertain significance Single submitter
- E2F5 p.Met162Lys Uncertain significance Single submitter
- E2F5 p.Pro23Ser Uncertain significance Single submitter
- E2F5 p.Pro27Leu Uncertain significance Single submitter
- E2F5 p.Pro321Leu Uncertain significance Single submitter
- E2F5 p.Pro33Arg Uncertain significance Single submitter
- E2F5 p.Pro35Ser Uncertain significance Single submitter
- E2F5 p.Pro39Arg Uncertain significance Single submitter
- E2F5 p.Pro39Leu Uncertain significance Single submitter
- E2F5 p.Ser278Phe Uncertain significance Single submitter
- E2F5 p.Ser299Ile Uncertain significance Single submitter
- E2F5 p.Ser48Ile Uncertain significance Single submitter
- E2F5 p.Thr82Ile Uncertain significance Single submitter
- E2F5 p.Tyr325Phe Uncertain significance Single submitter
All E2F5 variants
Likely benign 1
- p.Gln270Glu Single submitter
Uncertain significance 47
- p.Ala192Ser Single submitter ⚠
- p.Ala295Glu Single submitter ⚠
- p.Ala44Thr Single submitter ⚠
- p.Ala44Val Single submitter ⚠
- p.Ala78Glu Single submitter ⚠
- p.Asn183Lys Single submitter ⚠
- p.Asp163Gly Single submitter ⚠
- p.Asp177Glu Single submitter ⚠
- p.Asp301Glu Single submitter ⚠
- p.Asp301Gly Single submitter ⚠
- p.Asp324Asn Single submitter ⚠
- p.Asp71Asn Single submitter ⚠
- p.Asp81Ala Single submitter ⚠
- p.Asp81Glu Single submitter ⚠
- p.Asp81Val Single submitter ⚠
- p.Gln11Pro Single submitter ⚠
- p.Gln156His Single submitter ⚠
- p.Gln197Glu Single submitter ⚠
- p.Gln207His Single submitter ⚠
- p.Gln285Lys Single submitter ⚠
- p.Gln286Arg Single submitter ⚠
- p.Gln31Arg Single submitter ⚠
- p.Glu232Gln Single submitter ⚠
- p.Gly42Arg Single submitter ⚠
- p.Gly47Ser Single submitter ⚠
- p.His276Pro Single submitter ⚠
- p.Ile104Leu Single submitter ⚠
- p.Ile112Val Single submitter ⚠
- p.Ile127Met Single submitter ⚠
- p.Ile229Val Single submitter ⚠
- p.Leu249Phe Single submitter ⚠
- p.Met162Lys Single submitter ⚠
- p.Pro23Ser Single submitter ⚠
- p.Pro27Leu Single submitter ⚠
- p.Pro321Leu Single submitter ⚠
- p.Pro33Arg Single submitter ⚠
- p.Pro35Ser Single submitter ⚠
- p.Pro39Arg Single submitter ⚠
- p.Pro39Leu Single submitter ⚠
- p.Ser157Asn Single submitter ⚠
- p.Ser278Phe Single submitter ⚠
- p.Ser299Ile Single submitter ⚠
- p.Ser48Ile Single submitter ⚠
- p.Thr196Ile Single submitter ⚠
- p.Thr269Pro Single submitter ⚠
- p.Thr82Ile Single submitter ⚠
- p.Tyr325Phe Single submitter ⚠