E2F7 — 119 ClinVar variants
All ClinVar germline E2F7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 108 flagged for review →
6 Benign · 5 Likely benign · 108 Uncertain significance
Full E2F7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 108
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 86
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- E2F7 p.Ala117Thr Uncertain significance Single submitter
- E2F7 p.Ala131Thr Uncertain significance Single submitter
- E2F7 p.Ala406Ser Uncertain significance Single submitter
- E2F7 p.Ala466Val Uncertain significance Single submitter
- E2F7 p.Ala637Pro Uncertain significance Single submitter
- E2F7 p.Ala669Ser Uncertain significance Single submitter
- E2F7 p.Arg157Cys Uncertain significance Single submitter
- E2F7 p.Arg15Lys Uncertain significance Single submitter
- E2F7 p.Arg407Ser Uncertain significance Single submitter
- E2F7 p.Arg422Gly Uncertain significance Single submitter
- E2F7 p.Arg890Ser Uncertain significance Single submitter
- E2F7 p.Asn459Tyr Uncertain significance Single submitter
- E2F7 p.Asn716Ser Uncertain significance Single submitter
- E2F7 p.Asp120Gly Uncertain significance Single submitter
- E2F7 p.Asp256Gly Uncertain significance Single submitter
- E2F7 p.Asp268Asn Uncertain significance Single submitter
- E2F7 p.Asp268Glu Uncertain significance Single submitter
- E2F7 p.Asp523Glu Uncertain significance Single submitter
- E2F7 p.Gln223Arg Uncertain significance Single submitter
- E2F7 p.Gln262Arg Uncertain significance Single submitter
- E2F7 p.Gln603Arg Uncertain significance Single submitter
- E2F7 p.Gln603Glu Uncertain significance Single submitter
- E2F7 p.Gln77His Uncertain significance Single submitter
- E2F7 p.Gln837Lys Uncertain significance Single submitter
- E2F7 p.Gln892His Uncertain significance Single submitter
- E2F7 p.Glu434Gln Uncertain significance Single submitter
- E2F7 p.Gly395Asp Uncertain significance Single submitter
- E2F7 p.Gly517Ser Uncertain significance Single submitter
- E2F7 p.Gly570Arg Uncertain significance Single submitter
- E2F7 p.Gly570Glu Uncertain significance Single submitter
- E2F7 p.Gly736Ser Uncertain significance Single submitter
- E2F7 p.Gly909Ser Uncertain significance Single submitter
- E2F7 p.His197Gln Uncertain significance Single submitter
- E2F7 p.His352Tyr Uncertain significance Single submitter
- E2F7 p.Ile12Met Uncertain significance Single submitter
- E2F7 p.Ile47Val Uncertain significance Single submitter
- E2F7 p.Ile52Thr Uncertain significance Single submitter
- E2F7 p.Ile98Val Uncertain significance Single submitter
- E2F7 p.Leu122Val Uncertain significance Single submitter
- E2F7 p.Leu448Val Uncertain significance Single submitter
- E2F7 p.Leu596Pro Uncertain significance Single submitter
- E2F7 p.Lys103Arg Uncertain significance Single submitter
- E2F7 p.Lys283Glu Uncertain significance Single submitter
- E2F7 p.Lys651Asn Uncertain significance Single submitter
- E2F7 p.Lys71Glu Uncertain significance Single submitter
- E2F7 p.Met41Ile Uncertain significance Single submitter
- E2F7 p.Met642Ile Uncertain significance Single submitter
- E2F7 p.Met642Thr Uncertain significance Single submitter
- E2F7 p.Met746Thr Uncertain significance Single submitter
- E2F7 p.Met746Val Uncertain significance Single submitter
- E2F7 p.Phe250Ser Uncertain significance Single submitter
- E2F7 p.Phe411Leu Uncertain significance Single submitter
- E2F7 p.Pro323Ser Uncertain significance Single submitter
- E2F7 p.Pro428Ser Uncertain significance Single submitter
- E2F7 p.Pro473Thr Uncertain significance Single submitter
- E2F7 p.Pro479His Uncertain significance Single submitter
- E2F7 p.Pro484Ser Uncertain significance Single submitter
- E2F7 p.Pro51Ser Uncertain significance Single submitter
- E2F7 p.Pro565Thr Uncertain significance Single submitter
- E2F7 p.Pro649Ser Uncertain significance Single submitter
- E2F7 p.Pro682Leu Uncertain significance Single submitter
- E2F7 p.Pro739Leu Uncertain significance Single submitter
- E2F7 p.Pro767Leu Uncertain significance Single submitter
- E2F7 p.Pro780Ser Uncertain significance Single submitter
- E2F7 p.Pro780Thr Uncertain significance Single submitter
- E2F7 p.Pro820Ala Uncertain significance Single submitter
- E2F7 p.Pro96Arg Uncertain significance Single submitter
- E2F7 p.Ser214Asn Uncertain significance Single submitter
- E2F7 p.Ser551Pro Uncertain significance Single submitter
- E2F7 p.Ser647Phe Uncertain significance Single submitter
- E2F7 p.Ser856Pro Uncertain significance Single submitter
- E2F7 p.Ser897Gly Uncertain significance Single submitter
- E2F7 p.Thr165Asn Uncertain significance Single submitter
- E2F7 p.Thr727Ile Uncertain significance Single submitter
- E2F7 p.Thr778Ala Uncertain significance Single submitter
- E2F7 p.Tyr452Cys Uncertain significance Single submitter
- E2F7 p.Tyr760Cys Uncertain significance Single submitter
- E2F7 p.Val127Gly Uncertain significance Single submitter
- E2F7 p.Val181Met Uncertain significance Single submitter
- E2F7 p.Val547Ala Uncertain significance Single submitter
- E2F7 p.Val675Asp Uncertain significance Single submitter
- E2F7 p.Val70Ala Uncertain significance Single submitter
- E2F7 p.Val73Asp Uncertain significance Single submitter
- E2F7 p.Val743Gly Uncertain significance Single submitter
- E2F7 p.Val844Leu Uncertain significance Single submitter
- E2F7 p.Val858Leu Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- E2F7 p.Arg253Cys Uncertain significance Single submitter
- E2F7 p.Arg902Ser Uncertain significance Single submitter
- E2F7 p.Asp273Tyr Uncertain significance Single submitter
- E2F7 p.Gln152Arg Uncertain significance Single submitter
- E2F7 p.Glu377Gln Uncertain significance Single submitter
- E2F7 p.Glu604Lys Uncertain significance Single submitter
- E2F7 p.Gly724Arg Uncertain significance Single submitter
- E2F7 p.Gly773Asp Uncertain significance Single submitter
- E2F7 p.Pro46Ser Uncertain significance Single submitter
- E2F7 p.Pro621Leu Uncertain significance Single submitter
- E2F7 p.Pro712Arg Uncertain significance Single submitter
- E2F7 p.Pro712Leu Uncertain significance Single submitter
- E2F7 p.Pro767Arg Uncertain significance Single submitter
- E2F7 p.Pro826Arg Uncertain significance Single submitter
- E2F7 p.Ser551Phe Uncertain significance Single submitter
- E2F7 p.Ser723Phe Uncertain significance Single submitter
- E2F7 p.Ser742Arg Uncertain significance Single submitter
- E2F7 p.Ser833Ile Uncertain significance Single submitter
- E2F7 p.Ser856Leu Uncertain significance Single submitter
- E2F7 p.Thr507Met Uncertain significance Single submitter
- E2F7 p.Trp81Ser Uncertain significance Single submitter
- E2F7 p.Val353Ile Uncertain significance Single submitter
All E2F7 variants
Benign 6
Likely benign 5
- p.Ala78Val Single submitter
- p.Gly620Ser Single submitter
- p.Ile791Thr Single submitter
- p.Lys404Arg Single submitter
- p.Val844Met Single submitter
Uncertain significance 108
- p.Ala117Thr Single submitter ⚠
- p.Ala131Thr Single submitter ⚠
- p.Ala406Ser Single submitter ⚠
- p.Ala466Val Single submitter ⚠
- p.Ala637Pro Single submitter ⚠
- p.Ala669Ser Single submitter ⚠
- p.Arg157Cys Single submitter ⚠
- p.Arg15Lys Single submitter ⚠
- p.Arg253Cys Single submitter ⚠
- p.Arg407Ser Single submitter ⚠
- p.Arg422Gly Single submitter ⚠
- p.Arg890Ser Single submitter ⚠
- p.Arg902Ser Single submitter ⚠
- p.Asn459Tyr Single submitter ⚠
- p.Asn716Ser Single submitter ⚠
- p.Asp120Gly Single submitter ⚠
- p.Asp256Gly Single submitter ⚠
- p.Asp268Asn Single submitter ⚠
- p.Asp268Glu Single submitter ⚠
- p.Asp273Tyr Single submitter ⚠
- p.Asp523Glu Single submitter ⚠
- p.Gln152Arg Single submitter ⚠
- p.Gln223Arg Single submitter ⚠
- p.Gln262Arg Single submitter ⚠
- p.Gln603Arg Single submitter ⚠
- p.Gln603Glu Single submitter ⚠
- p.Gln77His Single submitter ⚠
- p.Gln837Lys Single submitter ⚠
- p.Gln892His Single submitter ⚠
- p.Glu377Gln Single submitter ⚠
- p.Glu434Gln Single submitter ⚠
- p.Glu604Lys Single submitter ⚠
- p.Gly395Asp Single submitter ⚠
- p.Gly517Ser Single submitter ⚠
- p.Gly570Arg Single submitter ⚠
- p.Gly570Glu Single submitter ⚠
- p.Gly724Arg Single submitter ⚠
- p.Gly736Ser Single submitter ⚠
- p.Gly773Asp Single submitter ⚠
- p.Gly909Ser Single submitter ⚠
- p.His197Gln Single submitter ⚠
- p.His352Tyr Single submitter ⚠
- p.Ile12Met Single submitter ⚠
- p.Ile47Val Single submitter ⚠
- p.Ile52Thr Single submitter ⚠
- p.Ile98Val Single submitter ⚠
- p.Leu122Val Single submitter ⚠
- p.Leu448Val Single submitter ⚠
- p.Leu596Pro Single submitter ⚠
- p.Lys103Arg Single submitter ⚠
- p.Lys283Glu Single submitter ⚠
- p.Lys651Asn Single submitter ⚠
- p.Lys71Glu Single submitter ⚠
- p.Met41Ile Single submitter ⚠
- p.Met642Ile Single submitter ⚠
- p.Met642Thr Single submitter ⚠
- p.Met746Thr Single submitter ⚠
- p.Met746Val Single submitter ⚠
- p.Phe250Ser Single submitter ⚠
- p.Phe411Leu Single submitter ⚠
- p.Pro323Ser Single submitter ⚠
- p.Pro428Ser Single submitter ⚠
- p.Pro46Ser Single submitter ⚠
- p.Pro473Thr Single submitter ⚠
- p.Pro479His Single submitter ⚠
- p.Pro484Ser Single submitter ⚠
- p.Pro51Ser Single submitter ⚠
- p.Pro565Thr Single submitter ⚠
- p.Pro621Leu Single submitter ⚠
- p.Pro649Ser Single submitter ⚠
- p.Pro682Leu Single submitter ⚠
- p.Pro712Arg Single submitter ⚠
- p.Pro712Leu Single submitter ⚠
- p.Pro739Leu Single submitter ⚠
- p.Pro767Arg Single submitter ⚠
- p.Pro767Leu Single submitter ⚠
- p.Pro780Ser Single submitter ⚠
- p.Pro780Thr Single submitter ⚠
- p.Pro820Ala Single submitter ⚠
- p.Pro826Arg Single submitter ⚠
- p.Pro96Arg Single submitter ⚠
- p.Ser214Asn Single submitter ⚠
- p.Ser551Phe Single submitter ⚠
- p.Ser551Pro Single submitter ⚠
- p.Ser647Phe Single submitter ⚠
- p.Ser723Phe Single submitter ⚠
- p.Ser742Arg Single submitter ⚠
- p.Ser833Ile Single submitter ⚠
- p.Ser856Leu Single submitter ⚠
- p.Ser856Pro Single submitter ⚠
- p.Ser897Gly Single submitter ⚠
- p.Thr165Asn Single submitter ⚠
- p.Thr507Met Single submitter ⚠
- p.Thr727Ile Single submitter ⚠
- p.Thr778Ala Single submitter ⚠
- p.Trp81Ser Single submitter ⚠
- p.Tyr452Cys Single submitter ⚠
- p.Tyr760Cys Single submitter ⚠
- p.Val127Gly Single submitter ⚠
- p.Val181Met Single submitter ⚠
- p.Val353Ile Single submitter ⚠
- p.Val547Ala Single submitter ⚠
- p.Val675Asp Single submitter ⚠
- p.Val70Ala Single submitter ⚠
- p.Val73Asp Single submitter ⚠
- p.Val743Gly Single submitter ⚠
- p.Val844Leu Single submitter ⚠
- p.Val858Leu Single submitter ⚠