E2F8 — 119 ClinVar variants
All ClinVar germline E2F8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 105 flagged for review →
8 Benign · 6 Likely benign · 105 Uncertain significance
Full E2F8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 105
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 81
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- E2F8 p.Ala28Glu Uncertain significance Single submitter
- E2F8 p.Ala487Val Uncertain significance Single submitter
- E2F8 p.Ala585Gly Uncertain significance Single submitter
- E2F8 p.Ala61Thr Uncertain significance Single submitter
- E2F8 p.Arg113Gln Uncertain significance Single submitter
- E2F8 p.Arg254Gln Uncertain significance Single submitter
- E2F8 p.Arg465Ile Uncertain significance Single submitter
- E2F8 p.Arg781Lys Uncertain significance Single submitter
- E2F8 p.Arg81Lys Uncertain significance Single submitter
- E2F8 p.Arg825His Uncertain significance Single submitter
- E2F8 p.Asn134Asp Uncertain significance Single submitter
- E2F8 p.Asn728Ile Uncertain significance Single submitter
- E2F8 p.Asp95Glu Uncertain significance Single submitter
- E2F8 p.Gln794Pro Uncertain significance Single submitter
- E2F8 p.Gln798His Uncertain significance Single submitter
- E2F8 p.Gln856Arg Uncertain significance Single submitter
- E2F8 p.Glu11Gly Uncertain significance Single submitter
- E2F8 p.Glu227Lys Uncertain significance Single submitter
- E2F8 p.Glu376Val Uncertain significance Single submitter
- E2F8 p.Glu564Ala Uncertain significance Single submitter
- E2F8 p.Glu621Asp Uncertain significance Single submitter
- E2F8 p.Glu766Asp Uncertain significance Single submitter
- E2F8 p.Glu92Ala Uncertain significance Single submitter
- E2F8 p.Gly239Glu Uncertain significance Single submitter
- E2F8 p.Gly40Arg Uncertain significance Single submitter
- E2F8 p.Gly467Glu Uncertain significance Single submitter
- E2F8 p.Gly590Glu Uncertain significance Single submitter
- E2F8 p.Gly676Ala Uncertain significance Single submitter
- E2F8 p.His100Pro Uncertain significance Single submitter
- E2F8 p.His299Pro Uncertain significance Single submitter
- E2F8 p.His362Asn Uncertain significance Single submitter
- E2F8 p.His362Asp Uncertain significance Single submitter
- E2F8 p.His548Tyr Uncertain significance Single submitter
- E2F8 p.His667Asp Uncertain significance Single submitter
- E2F8 p.His98Pro Uncertain significance Single submitter
- E2F8 p.Ile226Thr Uncertain significance Single submitter
- E2F8 p.Ile230Asn Uncertain significance Single submitter
- E2F8 p.Ile284Arg Uncertain significance Single submitter
- E2F8 p.Ile284Thr Uncertain significance Single submitter
- E2F8 p.Ile30Thr Uncertain significance Single submitter
- E2F8 p.Ile30Val Uncertain significance Single submitter
- E2F8 p.Ile419Met Uncertain significance Single submitter
- E2F8 p.Ile726Thr Uncertain significance Single submitter
- E2F8 p.Leu663Pro Uncertain significance Single submitter
- E2F8 p.Leu685Pro Uncertain significance Single submitter
- E2F8 p.Leu859Pro Uncertain significance Single submitter
- E2F8 p.Lys212Arg Uncertain significance Single submitter
- E2F8 p.Lys423Glu Uncertain significance Single submitter
- E2F8 p.Lys47Glu Uncertain significance Single submitter
- E2F8 p.Lys49Arg Uncertain significance Single submitter
- E2F8 p.Met208Ile Uncertain significance Single submitter
- E2F8 p.Met483Val Uncertain significance Single submitter
- E2F8 p.Met609Thr Uncertain significance Single submitter
- E2F8 p.Met701Thr Uncertain significance Single submitter
- E2F8 p.Phe253Cys Uncertain significance Single submitter
- E2F8 p.Phe634Cys Uncertain significance Single submitter
- E2F8 p.Phe690Ile Uncertain significance Single submitter
- E2F8 p.Phe853Leu Uncertain significance Single submitter
- E2F8 p.Pro130Ser Uncertain significance Single submitter
- E2F8 p.Pro341Leu Uncertain significance Single submitter
- E2F8 p.Pro365Ala Uncertain significance Single submitter
- E2F8 p.Pro45Ser Uncertain significance Single submitter
- E2F8 p.Pro468Arg Uncertain significance Single submitter
- E2F8 p.Pro478Leu Uncertain significance Single submitter
- E2F8 p.Pro716Leu Uncertain significance Single submitter
- E2F8 p.Pro788Gln Uncertain significance Single submitter
- E2F8 p.Ser324Asn Uncertain significance Single submitter
- E2F8 p.Ser355Gly Uncertain significance Single submitter
- E2F8 p.Ser615Pro Uncertain significance Single submitter
- E2F8 p.Ser655Pro Uncertain significance Single submitter
- E2F8 p.Ser682Pro Uncertain significance Single submitter
- E2F8 p.Thr27Ser Uncertain significance Single submitter
- E2F8 p.Val251Met Uncertain significance Single submitter
- E2F8 p.Val370Leu Uncertain significance Single submitter
- E2F8 p.Val401Ala Uncertain significance Single submitter
- E2F8 p.Val459Met Uncertain significance Single submitter
- E2F8 p.Val710Ala Uncertain significance Single submitter
- E2F8 p.Val710Ile Uncertain significance Single submitter
- E2F8 p.Val712Ile Uncertain significance Single submitter
- E2F8 p.Val759Ala Uncertain significance Single submitter
- E2F8 p.Val759Ile Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- E2F8 p.Ala507Glu Uncertain significance Single submitter
- E2F8 p.Arg128Gln Uncertain significance Single submitter
- E2F8 p.Arg393Gln Uncertain significance Single submitter
- E2F8 p.Arg408Gln Uncertain significance Single submitter
- E2F8 p.Arg408Trp Uncertain significance Single submitter
- E2F8 p.Arg81Met Uncertain significance Single submitter
- E2F8 p.Asn422Tyr Uncertain significance Single submitter
- E2F8 p.Asp612Tyr Uncertain significance Single submitter
- E2F8 p.Glu204Lys Uncertain significance Single submitter
- E2F8 p.Glu213Gly Uncertain significance Single submitter
- E2F8 p.Glu611Lys Uncertain significance Single submitter
- E2F8 p.Gly250Glu Uncertain significance Single submitter
- E2F8 p.Ile295Thr Uncertain significance Single submitter
- E2F8 p.Ile398Thr Uncertain significance Single submitter
- E2F8 p.Leu633Met Uncertain significance Single submitter
- E2F8 p.Leu633Phe Uncertain significance Single submitter
- E2F8 p.Pro135Arg Uncertain significance Single submitter
- E2F8 p.Pro697Leu Uncertain significance Single submitter
- E2F8 p.Ser406Gly Uncertain significance Single submitter
- E2F8 p.Thr281Ala Uncertain significance Single submitter
- E2F8 p.Thr535Met Uncertain significance Single submitter
- E2F8 p.Thr643Met Uncertain significance Single submitter
- E2F8 p.Val497Asp Uncertain significance Single submitter
- E2F8 p.Val761Met Uncertain significance Single submitter
All E2F8 variants
Benign 8
- p.Asn845Ser Multiple submitters
- p.Ile674Val Multiple submitters
- p.Ser358Thr Multiple submitters
- p.Thr26= Multiple submitters
- p.Thr632= Multiple submitters
- p.Val770= Multiple submitters
- p.Pro697= Single submitter
- p.Ser68= Single submitter
Likely benign 6
- p.Ala719Thr Single submitter
- p.Arg372Gln Single submitter
- p.Asn747Ser Single submitter
- p.Asn769Ser Single submitter
- p.Ile231Thr Single submitter
- p.Thr346= Single submitter
Uncertain significance 105
- p.Ala28Glu Single submitter ⚠
- p.Ala487Val Single submitter ⚠
- p.Ala507Glu Single submitter ⚠
- p.Ala585Gly Single submitter ⚠
- p.Ala61Thr Single submitter ⚠
- p.Arg113Gln Single submitter ⚠
- p.Arg128Gln Single submitter ⚠
- p.Arg254Gln Single submitter ⚠
- p.Arg393Gln Single submitter ⚠
- p.Arg408Gln Single submitter ⚠
- p.Arg408Trp Single submitter ⚠
- p.Arg465Ile Single submitter ⚠
- p.Arg781Lys Single submitter ⚠
- p.Arg81Lys Single submitter ⚠
- p.Arg81Met Single submitter ⚠
- p.Arg825His Single submitter ⚠
- p.Asn134Asp Single submitter ⚠
- p.Asn422Tyr Single submitter ⚠
- p.Asn728Ile Single submitter ⚠
- p.Asp612Tyr Single submitter ⚠
- p.Asp95Glu Single submitter ⚠
- p.Gln794Pro Single submitter ⚠
- p.Gln798His Single submitter ⚠
- p.Gln856Arg Single submitter ⚠
- p.Glu11Gly Single submitter ⚠
- p.Glu204Lys Single submitter ⚠
- p.Glu213Gly Single submitter ⚠
- p.Glu227Lys Single submitter ⚠
- p.Glu376Val Single submitter ⚠
- p.Glu564Ala Single submitter ⚠
- p.Glu611Lys Single submitter ⚠
- p.Glu621Asp Single submitter ⚠
- p.Glu766Asp Single submitter ⚠
- p.Glu92Ala Single submitter ⚠
- p.Gly239Glu Single submitter ⚠
- p.Gly250Glu Single submitter ⚠
- p.Gly40Arg Single submitter ⚠
- p.Gly467Glu Single submitter ⚠
- p.Gly590Glu Single submitter ⚠
- p.Gly676Ala Single submitter ⚠
- p.His100Pro Single submitter ⚠
- p.His299Pro Single submitter ⚠
- p.His362Asn Single submitter ⚠
- p.His362Asp Single submitter ⚠
- p.His548Tyr Single submitter ⚠
- p.His667Asp Single submitter ⚠
- p.His98Pro Single submitter ⚠
- p.Ile226Thr Single submitter ⚠
- p.Ile230Asn Single submitter ⚠
- p.Ile284Arg Single submitter ⚠
- p.Ile284Thr Single submitter ⚠
- p.Ile295Thr Single submitter ⚠
- p.Ile30Thr Single submitter ⚠
- p.Ile30Val Single submitter ⚠
- p.Ile398Thr Single submitter ⚠
- p.Ile419Met Single submitter ⚠
- p.Ile726Thr Single submitter ⚠
- p.Leu633Met Single submitter ⚠
- p.Leu633Phe Single submitter ⚠
- p.Leu663Pro Single submitter ⚠
- p.Leu685Pro Single submitter ⚠
- p.Leu859Pro Single submitter ⚠
- p.Lys212Arg Single submitter ⚠
- p.Lys423Glu Single submitter ⚠
- p.Lys47Glu Single submitter ⚠
- p.Lys49Arg Single submitter ⚠
- p.Met208Ile Single submitter ⚠
- p.Met483Val Single submitter ⚠
- p.Met609Thr Single submitter ⚠
- p.Met701Thr Single submitter ⚠
- p.Phe253Cys Single submitter ⚠
- p.Phe634Cys Single submitter ⚠
- p.Phe690Ile Single submitter ⚠
- p.Phe853Leu Single submitter ⚠
- p.Pro130Ser Single submitter ⚠
- p.Pro135Arg Single submitter ⚠
- p.Pro341Leu Single submitter ⚠
- p.Pro365Ala Single submitter ⚠
- p.Pro45Ser Single submitter ⚠
- p.Pro468Arg Single submitter ⚠
- p.Pro478Leu Single submitter ⚠
- p.Pro697Leu Single submitter ⚠
- p.Pro716Leu Single submitter ⚠
- p.Pro788Gln Single submitter ⚠
- p.Ser324Asn Single submitter ⚠
- p.Ser355Gly Single submitter ⚠
- p.Ser406Gly Single submitter ⚠
- p.Ser615Pro Single submitter ⚠
- p.Ser655Pro Single submitter ⚠
- p.Ser682Pro Single submitter ⚠
- p.Thr27Ser Single submitter ⚠
- p.Thr281Ala Single submitter ⚠
- p.Thr535Met Single submitter ⚠
- p.Thr643Met Single submitter ⚠
- p.Val251Met Single submitter ⚠
- p.Val370Leu Single submitter ⚠
- p.Val401Ala Single submitter ⚠
- p.Val459Met Single submitter ⚠
- p.Val497Asp Single submitter ⚠
- p.Val710Ala Single submitter ⚠
- p.Val710Ile Single submitter ⚠
- p.Val712Ile Single submitter ⚠
- p.Val759Ala Single submitter ⚠
- p.Val759Ile Single submitter ⚠
- p.Val761Met Single submitter ⚠