EBNA1BP2 — 36 ClinVar variants
All ClinVar germline EBNA1BP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
2 Benign · 1 Likely benign · 33 Uncertain significance
Full EBNA1BP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EBNA1BP2 p.Ala112Val Uncertain significance Single submitter
- EBNA1BP2 p.Ala141Gly Uncertain significance Single submitter
- EBNA1BP2 p.Arg262Gln Uncertain significance Single submitter
- EBNA1BP2 p.Glu263Asp Uncertain significance Single submitter
- EBNA1BP2 p.Glu41Asp Uncertain significance Single submitter
- EBNA1BP2 p.Gly249Cys Uncertain significance Single submitter
- EBNA1BP2 p.Leu281Phe Uncertain significance Single submitter
- EBNA1BP2 p.Leu6Val Uncertain significance Single submitter
- EBNA1BP2 p.Lys287Glu Uncertain significance Single submitter
- EBNA1BP2 p.Lys44Arg Uncertain significance Single submitter
- EBNA1BP2 p.Met161Val Uncertain significance Single submitter
- EBNA1BP2 p.Pro293Ser Uncertain significance Single submitter
- EBNA1BP2 p.Pro43Thr Uncertain significance Single submitter
- EBNA1BP2 p.Pro86Leu Uncertain significance Single submitter
- EBNA1BP2 p.Thr182Met Uncertain significance Single submitter
- EBNA1BP2 p.Val38Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- EBNA1BP2 p.Asn290Ile Benign Multiple submitters
- EBNA1BP2 p.Ala141Thr Uncertain significance Single submitter
- EBNA1BP2 p.Ala198Gly Uncertain significance Single submitter
- EBNA1BP2 p.Arg110Gly Uncertain significance Single submitter
- EBNA1BP2 p.Arg122His Uncertain significance Single submitter
- EBNA1BP2 p.Arg151Gln Uncertain significance Single submitter
- EBNA1BP2 p.Asp25His Uncertain significance Single submitter
- EBNA1BP2 p.Gln103Pro Uncertain significance Single submitter
- EBNA1BP2 p.Gln125His Uncertain significance Single submitter
- EBNA1BP2 p.Lys142Arg Uncertain significance Single submitter
- EBNA1BP2 p.Lys178Arg Uncertain significance Single submitter
- EBNA1BP2 p.Ser11Leu Uncertain significance Single submitter
- EBNA1BP2 p.Ser16Pro Uncertain significance Single submitter
- EBNA1BP2 p.Ser207Pro Uncertain significance Single submitter
- EBNA1BP2 p.Tyr243Cys Uncertain significance Single submitter
- EBNA1BP2 p.Val184Ile Uncertain significance Single submitter
All EBNA1BP2 variants
Benign 2
- p.Asn290Ile Multiple submitters ⚠
- p.Pro76Arg Multiple submitters
Likely benign 1
- p.Thr305Ala Single submitter
Uncertain significance 33
- c.-14G>T Single submitter
- p.Ala112Val Single submitter ⚠
- p.Ala141Gly Single submitter ⚠
- p.Ala141Thr Single submitter ⚠
- p.Ala198Gly Single submitter ⚠
- p.Arg110Gly Single submitter ⚠
- p.Arg122His Single submitter ⚠
- p.Arg151Gln Single submitter ⚠
- p.Arg262Gln Single submitter ⚠
- p.Asp25His Single submitter ⚠
- p.Gln103Pro Single submitter ⚠
- p.Gln125His Single submitter ⚠
- p.Glu263Asp Single submitter ⚠
- p.Glu41Asp Single submitter ⚠
- p.Gly249Cys Single submitter ⚠
- p.Leu281Phe Single submitter ⚠
- p.Leu6Val Single submitter ⚠
- p.Lys142Arg Single submitter ⚠
- p.Lys178Arg Single submitter ⚠
- p.Lys287Glu Single submitter ⚠
- p.Lys44Arg Single submitter ⚠
- p.Met161Val Single submitter ⚠
- p.Pro293Ser Single submitter ⚠
- p.Pro43Thr Single submitter ⚠
- p.Pro86Leu Single submitter ⚠
- p.Ser11Leu Single submitter ⚠
- p.Ser16Pro Single submitter ⚠
- p.Ser207Pro Single submitter ⚠
- p.Thr182Met Single submitter ⚠
- p.Tyr243Cys Single submitter ⚠
- p.Tyr2Cys Single submitter
- p.Val184Ile Single submitter ⚠
- p.Val38Ile Single submitter ⚠