EEIG1 — 74 ClinVar variants
All ClinVar germline EEIG1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
1 Likely benign · 73 Uncertain significance
Full EEIG1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 58
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EEIG1 p.Arg118His Uncertain significance Single submitter
- EEIG1 p.Arg194Gln Uncertain significance Single submitter
- EEIG1 p.Arg228Gly Uncertain significance Single submitter
- EEIG1 p.Arg248Cys Uncertain significance Single submitter
- EEIG1 p.Arg258His Uncertain significance Single submitter
- EEIG1 p.Arg259Gly Uncertain significance Single submitter
- EEIG1 p.Arg283Gln Uncertain significance Single submitter
- EEIG1 p.Arg283Trp Uncertain significance Single submitter
- EEIG1 p.Arg286Gln Uncertain significance Single submitter
- EEIG1 p.Arg293Gln Uncertain significance Single submitter
- EEIG1 p.Arg296Gln Uncertain significance Single submitter
- EEIG1 p.Arg88Cys Uncertain significance Single submitter
- EEIG1 p.Asp212Tyr Uncertain significance Single submitter
- EEIG1 p.Asp302Asn Uncertain significance Single submitter
- EEIG1 p.Asp302Glu Uncertain significance Single submitter
- EEIG1 p.Asp320Gly Uncertain significance Single submitter
- EEIG1 p.Asp325Asn Uncertain significance Single submitter
- EEIG1 p.Cys81Arg Uncertain significance Single submitter
- EEIG1 p.Glu109Lys Uncertain significance Single submitter
- EEIG1 p.Glu210Lys Uncertain significance Single submitter
- EEIG1 p.Glu284Lys Uncertain significance Single submitter
- EEIG1 p.Glu313Gly Uncertain significance Single submitter
- EEIG1 p.Glu377Lys Uncertain significance Single submitter
- EEIG1 p.Gly148Glu Uncertain significance Single submitter
- EEIG1 p.Gly269Ala Uncertain significance Single submitter
- EEIG1 p.Gly76Ser Uncertain significance Single submitter
- EEIG1 p.Leu203Phe Uncertain significance Single submitter
- EEIG1 p.Leu252Ile Uncertain significance Single submitter
- EEIG1 p.Lys61Arg Uncertain significance Single submitter
- EEIG1 p.Lys68Arg Uncertain significance Single submitter
- EEIG1 p.Lys8Asn Uncertain significance Single submitter
- EEIG1 p.Phe26Val Uncertain significance Single submitter
- EEIG1 p.Pro195Leu Uncertain significance Single submitter
- EEIG1 p.Pro195Ser Uncertain significance Single submitter
- EEIG1 p.Pro196Arg Uncertain significance Single submitter
- EEIG1 p.Pro196His Uncertain significance Single submitter
- EEIG1 p.Pro218Ser Uncertain significance Single submitter
- EEIG1 p.Pro292Leu Uncertain significance Single submitter
- EEIG1 p.Pro297Leu Uncertain significance Single submitter
- EEIG1 p.Pro73Leu Uncertain significance Single submitter
- EEIG1 p.Pro80Ser Uncertain significance Single submitter
- EEIG1 p.Ser157Leu Uncertain significance Single submitter
- EEIG1 p.Ser170Phe Uncertain significance Single submitter
- EEIG1 p.Ser181Thr Uncertain significance Single submitter
- EEIG1 p.Ser185Asn Uncertain significance Single submitter
- EEIG1 p.Ser186Asn Uncertain significance Single submitter
- EEIG1 p.Ser186Gly Uncertain significance Single submitter
- EEIG1 p.Ser264Gly Uncertain significance Single submitter
- EEIG1 p.Thr201Ser Uncertain significance Single submitter
- EEIG1 p.Thr256Met Uncertain significance Single submitter
- EEIG1 p.Thr274Asn Uncertain significance Single submitter
- EEIG1 p.Trp318Arg Uncertain significance Single submitter
- EEIG1 p.Tyr376Cys Uncertain significance Single submitter
- EEIG1 p.Val275Met Uncertain significance Single submitter
- EEIG1 p.Val312Ala Uncertain significance Single submitter
- EEIG1 p.Val375Ile Uncertain significance Single submitter
- EEIG1 p.Val44Ala Uncertain significance Single submitter
- EEIG1 p.Val66Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- EEIG1 p.Ala326Val Uncertain significance Single submitter
- EEIG1 p.Arg286Trp Uncertain significance Single submitter
- EEIG1 p.Arg296Trp Uncertain significance Single submitter
- EEIG1 p.Asp357Asn Uncertain significance Single submitter
- EEIG1 p.Pro291Leu Uncertain significance Single submitter
- EEIG1 p.Pro294Leu Uncertain significance Single submitter
- EEIG1 p.Ser147Cys Uncertain significance Single submitter
- EEIG1 p.Ser227Phe Uncertain significance Single submitter
- EEIG1 p.Thr127Met Uncertain significance Single submitter
- EEIG1 p.Thr361Arg Uncertain significance Single submitter
- EEIG1 p.Thr361Met Uncertain significance Single submitter
All EEIG1 variants
Likely benign 1
- p.Asp320= Single submitter
Uncertain significance 73
- p.Ala326Val Single submitter ⚠
- p.Arg118His Single submitter ⚠
- p.Arg194Gln Single submitter ⚠
- p.Arg228Gly Single submitter ⚠
- p.Arg248Cys Single submitter ⚠
- p.Arg258His Single submitter ⚠
- p.Arg259Gly Single submitter ⚠
- p.Arg283Gln Single submitter ⚠
- p.Arg283Trp Single submitter ⚠
- p.Arg286Gln Single submitter ⚠
- p.Arg286Trp Single submitter ⚠
- p.Arg293Gln Single submitter ⚠
- p.Arg296Gln Single submitter ⚠
- p.Arg296Trp Single submitter ⚠
- p.Arg88Cys Single submitter ⚠
- p.Asp212Tyr Single submitter ⚠
- p.Asp302Asn Single submitter ⚠
- p.Asp302Glu Single submitter ⚠
- p.Asp320Gly Single submitter ⚠
- p.Asp325Asn Single submitter ⚠
- p.Asp357Asn Single submitter ⚠
- p.Cys81Arg Single submitter ⚠
- p.Glu109Lys Single submitter ⚠
- p.Glu210Lys Single submitter ⚠
- p.Glu284Lys Single submitter ⚠
- p.Glu313Gly Single submitter ⚠
- p.Glu346Lys Single submitter
- p.Glu377Lys Single submitter ⚠
- p.Gly148Glu Single submitter ⚠
- p.Gly177Asp Single submitter
- p.Gly269Ala Single submitter ⚠
- p.Gly76Ser Single submitter ⚠
- p.Leu203Phe Single submitter ⚠
- p.Leu252Ile Single submitter ⚠
- p.Lys61Arg Single submitter ⚠
- p.Lys68Arg Single submitter ⚠
- p.Lys8Asn Single submitter ⚠
- p.Phe26Val Single submitter ⚠
- p.Pro155Gln Single submitter
- p.Pro195Leu Single submitter ⚠
- p.Pro195Ser Single submitter ⚠
- p.Pro196Arg Single submitter ⚠
- p.Pro196His Single submitter ⚠
- p.Pro218Ser Single submitter ⚠
- p.Pro291Leu Single submitter ⚠
- p.Pro292Leu Single submitter ⚠
- p.Pro294Leu Single submitter ⚠
- p.Pro297Leu Single submitter ⚠
- p.Pro73Leu Single submitter ⚠
- p.Pro80Ser Single submitter ⚠
- p.Ser147Cys Single submitter ⚠
- p.Ser157Leu Single submitter ⚠
- p.Ser170Phe Single submitter ⚠
- p.Ser181Thr Single submitter ⚠
- p.Ser185Asn Single submitter ⚠
- p.Ser186Asn Single submitter ⚠
- p.Ser186Gly Single submitter ⚠
- p.Ser227Phe Single submitter ⚠
- p.Ser247Leu Single submitter
- p.Ser264Gly Single submitter ⚠
- p.Thr127Met Single submitter ⚠
- p.Thr201Ser Single submitter ⚠
- p.Thr256Met Single submitter ⚠
- p.Thr274Asn Single submitter ⚠
- p.Thr361Arg Single submitter ⚠
- p.Thr361Met Single submitter ⚠
- p.Trp318Arg Single submitter ⚠
- p.Tyr376Cys Single submitter ⚠
- p.Val275Met Single submitter ⚠
- p.Val312Ala Single submitter ⚠
- p.Val375Ile Single submitter ⚠
- p.Val44Ala Single submitter ⚠
- p.Val66Met Single submitter ⚠