EGR4 — 128 ClinVar variants
All ClinVar germline EGR4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 117 flagged for review →
3 Benign · 7 Likely benign · 118 Uncertain significance
Full EGR4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 117
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 95
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EGR4 c.-102T>C Uncertain significance Single submitter
- EGR4 c.-110C>A Uncertain significance Single submitter
- EGR4 c.-111G>C Uncertain significance Single submitter
- EGR4 c.-113G>A Uncertain significance Single submitter
- EGR4 c.-117G>T Uncertain significance Single submitter
- EGR4 c.-123C>T Uncertain significance Single submitter
- EGR4 c.-132T>A Uncertain significance Single submitter
- EGR4 c.-155C>G Uncertain significance Single submitter
- EGR4 c.-176G>A Uncertain significance Single submitter
- EGR4 c.-191G>C Uncertain significance Single submitter
- EGR4 c.-200C>T Uncertain significance Single submitter
- EGR4 c.-210A>T Uncertain significance Single submitter
- EGR4 c.-219G>A Uncertain significance Single submitter
- EGR4 c.-2C>G Uncertain significance Single submitter
- EGR4 c.-35C>T Uncertain significance Single submitter
- EGR4 c.-53G>T Uncertain significance Single submitter
- EGR4 c.-56C>T Uncertain significance Single submitter
- EGR4 c.-69T>G Uncertain significance Single submitter
- EGR4 c.-72G>A Uncertain significance Single submitter
- EGR4 c.-90G>T Uncertain significance Single submitter
- EGR4 c.-9C>T Uncertain significance Single submitter
- EGR4 p.Ala13Glu Uncertain significance Single submitter
- EGR4 p.Ala161Asp Uncertain significance Single submitter
- EGR4 p.Ala165Val Uncertain significance Single submitter
- EGR4 p.Ala228Ser Uncertain significance Single submitter
- EGR4 p.Ala23Pro Uncertain significance Single submitter
- EGR4 p.Ala27Val Uncertain significance Single submitter
- EGR4 p.Ala340Val Uncertain significance Single submitter
- EGR4 p.Ala356Glu Uncertain significance Single submitter
- EGR4 p.Ala356Gly Uncertain significance Single submitter
- EGR4 p.Ala39Val Uncertain significance Single submitter
- EGR4 p.Ala467Ser Uncertain significance Single submitter
- EGR4 p.Arg232Cys Uncertain significance Single submitter
- EGR4 p.Arg232Pro Uncertain significance Single submitter
- EGR4 p.Arg317His Uncertain significance Single submitter
- EGR4 p.Arg402Leu Uncertain significance Single submitter
- EGR4 p.Arg417Pro Uncertain significance Single submitter
- EGR4 p.Arg5Gln Uncertain significance Single submitter
- EGR4 p.Arg5Pro Uncertain significance Single submitter
- EGR4 p.Asn398Tyr Uncertain significance Single submitter
- EGR4 p.Asp143Glu Uncertain significance Single submitter
- EGR4 p.Asp267Glu Uncertain significance Single submitter
- EGR4 p.Asp323Glu Uncertain significance Single submitter
- EGR4 p.Cys219Gly Uncertain significance Single submitter
- EGR4 p.Gln170Lys Uncertain significance Single submitter
- EGR4 p.Gln353Lys Uncertain significance Single submitter
- EGR4 p.Glu11Gln Uncertain significance Single submitter
- EGR4 p.Glu24Lys Uncertain significance Single submitter
- EGR4 p.Gly185Asp Uncertain significance Single submitter
- EGR4 p.Gly185Ser Uncertain significance Single submitter
- EGR4 p.Gly22Ser Uncertain significance Single submitter
- EGR4 p.Gly277Arg Uncertain significance Single submitter
- EGR4 p.Gly292Arg Uncertain significance Single submitter
- EGR4 p.Gly406Asp Uncertain significance Single submitter
- EGR4 p.Gly61Glu Uncertain significance Single submitter
- EGR4 p.Ile240Met Uncertain significance Single submitter
- EGR4 p.Leu186Phe Uncertain significance Single submitter
- EGR4 p.Leu2Phe Uncertain significance Single submitter
- EGR4 p.Leu328Pro Uncertain significance Single submitter
- EGR4 p.Phe158Ser Uncertain significance Single submitter
- EGR4 p.Pro12Ser Uncertain significance Single submitter
- EGR4 p.Pro12Thr Uncertain significance Single submitter
- EGR4 p.Pro139Ser Uncertain significance Single submitter
- EGR4 p.Pro15Leu Uncertain significance Single submitter
- EGR4 p.Pro175Ala Uncertain significance Single submitter
- EGR4 p.Pro207Leu Uncertain significance Single submitter
- EGR4 p.Pro249Arg Uncertain significance Single submitter
- EGR4 p.Pro253Arg Uncertain significance Single submitter
- EGR4 p.Pro325Leu Uncertain significance Single submitter
- EGR4 p.Pro342Ala Uncertain significance Single submitter
- EGR4 p.Pro344Leu Uncertain significance Single submitter
- EGR4 p.Pro347Leu Uncertain significance Single submitter
- EGR4 p.Pro383Arg Uncertain significance Single submitter
- EGR4 p.Pro38His Uncertain significance Single submitter
- EGR4 p.Pro44Ser Uncertain significance Single submitter
- EGR4 p.Pro72Thr Uncertain significance Single submitter
- EGR4 p.Pro76Ala Uncertain significance Single submitter
- EGR4 p.Pro76Thr Uncertain significance Single submitter
- EGR4 p.Pro77Ala Uncertain significance Single submitter
- EGR4 p.Ser124Thr Uncertain significance Single submitter
- EGR4 p.Ser162Leu Uncertain significance Single submitter
- EGR4 p.Ser169Leu Uncertain significance Single submitter
- EGR4 p.Ser335Arg Uncertain significance Single submitter
- EGR4 p.Ser394Phe Uncertain significance Single submitter
- EGR4 p.Ser478Thr Uncertain significance Single submitter
- EGR4 p.Ser56Asn Uncertain significance Single submitter
- EGR4 p.Thr349Ile Uncertain significance Single submitter
- EGR4 p.Thr433Ala Uncertain significance Single submitter
- EGR4 p.Trp20Leu Uncertain significance Single submitter
- EGR4 p.Trp20Ser Uncertain significance Single submitter
- EGR4 p.Tyr145Cys Uncertain significance Single submitter
- EGR4 p.Tyr145His Uncertain significance Single submitter
- EGR4 p.Tyr225Asp Uncertain significance Single submitter
- EGR4 p.Val255Leu Uncertain significance Single submitter
- EGR4 p.Val7Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- EGR4 p.Ala392Pro Uncertain significance Single submitter
- EGR4 p.Arg358Cys Uncertain significance Single submitter
- EGR4 p.Arg362Leu Uncertain significance Single submitter
- EGR4 p.Arg413Cys Uncertain significance Single submitter
- EGR4 p.Arg445His Uncertain significance Single submitter
- EGR4 p.Asn398Ser Uncertain significance Single submitter
- EGR4 p.Cys67Gly Uncertain significance Single submitter
- EGR4 p.Gly203Arg Uncertain significance Single submitter
- EGR4 p.Gly444Ser Uncertain significance Single submitter
- EGR4 p.Gly475Ser Uncertain significance Single submitter
- EGR4 p.Gly84Cys Uncertain significance Single submitter
- EGR4 p.Leu109Phe Uncertain significance Single submitter
- EGR4 p.Leu416Pro Uncertain significance Single submitter
- EGR4 p.Leu50Ser Uncertain significance Single submitter
- EGR4 p.Lys453Asn Uncertain significance Single submitter
- EGR4 p.Phe130Cys Uncertain significance Single submitter
- EGR4 p.Phe351Leu Uncertain significance Single submitter
- EGR4 p.Pro375Leu Uncertain significance Single submitter
- EGR4 p.Pro95Thr Uncertain significance Single submitter
- EGR4 p.Ser17Phe Uncertain significance Single submitter
- EGR4 p.Tyr477Asn Uncertain significance Single submitter
- EGR4 p.Tyr477Cys Uncertain significance Single submitter
All EGR4 variants
Likely benign 7
- c.-180G>A Single submitter
- p.Ala206= Single submitter
- p.Pro290Leu Single submitter
- p.Ser420= Single submitter
- p.Thr238Ala Single submitter
- p.Val198Ala Single submitter
- p.Val255Gly Single submitter
Uncertain significance 118
- c.13C>G Single submitter
- c.-102T>C Single submitter ⚠
- c.-110C>A Single submitter ⚠
- c.-111G>C Single submitter ⚠
- c.-113G>A Single submitter ⚠
- c.-117G>T Single submitter ⚠
- c.-123C>T Single submitter ⚠
- c.-132T>A Single submitter ⚠
- c.-155C>G Single submitter ⚠
- c.-176G>A Single submitter ⚠
- c.-191G>C Single submitter ⚠
- c.-200C>T Single submitter ⚠
- c.-210A>T Single submitter ⚠
- c.-219G>A Single submitter ⚠
- c.-2C>G Single submitter ⚠
- c.-35C>T Single submitter ⚠
- c.-53G>T Single submitter ⚠
- c.-56C>T Single submitter ⚠
- c.-69T>G Single submitter ⚠
- c.-72G>A Single submitter ⚠
- c.-90G>T Single submitter ⚠
- c.-9C>T Single submitter ⚠
- p.Ala13Glu Single submitter ⚠
- p.Ala161Asp Single submitter ⚠
- p.Ala165Val Single submitter ⚠
- p.Ala228Ser Single submitter ⚠
- p.Ala23Pro Single submitter ⚠
- p.Ala27Val Single submitter ⚠
- p.Ala340Val Single submitter ⚠
- p.Ala356Glu Single submitter ⚠
- p.Ala356Gly Single submitter ⚠
- p.Ala392Pro Single submitter ⚠
- p.Ala39Val Single submitter ⚠
- p.Ala467Ser Single submitter ⚠
- p.Arg232Cys Single submitter ⚠
- p.Arg232Pro Single submitter ⚠
- p.Arg317His Single submitter ⚠
- p.Arg358Cys Single submitter ⚠
- p.Arg362Leu Single submitter ⚠
- p.Arg402Leu Single submitter ⚠
- p.Arg413Cys Single submitter ⚠
- p.Arg417Pro Single submitter ⚠
- p.Arg445His Single submitter ⚠
- p.Arg5Gln Single submitter ⚠
- p.Arg5Pro Single submitter ⚠
- p.Asn398Ser Single submitter ⚠
- p.Asn398Tyr Single submitter ⚠
- p.Asp143Glu Single submitter ⚠
- p.Asp267Glu Single submitter ⚠
- p.Asp323Glu Single submitter ⚠
- p.Cys219Gly Single submitter ⚠
- p.Cys67Gly Single submitter ⚠
- p.Gln170Lys Single submitter ⚠
- p.Gln353Lys Single submitter ⚠
- p.Glu11Gln Single submitter ⚠
- p.Glu24Lys Single submitter ⚠
- p.Gly185Asp Single submitter ⚠
- p.Gly185Ser Single submitter ⚠
- p.Gly203Arg Single submitter ⚠
- p.Gly22Ser Single submitter ⚠
- p.Gly277Arg Single submitter ⚠
- p.Gly292Arg Single submitter ⚠
- p.Gly406Asp Single submitter ⚠
- p.Gly444Ser Single submitter ⚠
- p.Gly475Ser Single submitter ⚠
- p.Gly61Glu Single submitter ⚠
- p.Gly84Cys Single submitter ⚠
- p.Ile240Met Single submitter ⚠
- p.Leu109Phe Single submitter ⚠
- p.Leu186Phe Single submitter ⚠
- p.Leu2Phe Single submitter ⚠
- p.Leu328Pro Single submitter ⚠
- p.Leu416Pro Single submitter ⚠
- p.Leu50Ser Single submitter ⚠
- p.Lys453Asn Single submitter ⚠
- p.Phe130Cys Single submitter ⚠
- p.Phe158Ser Single submitter ⚠
- p.Phe351Leu Single submitter ⚠
- p.Pro12Ser Single submitter ⚠
- p.Pro12Thr Single submitter ⚠
- p.Pro139Ser Single submitter ⚠
- p.Pro15Leu Single submitter ⚠
- p.Pro175Ala Single submitter ⚠
- p.Pro207Leu Single submitter ⚠
- p.Pro249Arg Single submitter ⚠
- p.Pro253Arg Single submitter ⚠
- p.Pro325Leu Single submitter ⚠
- p.Pro342Ala Single submitter ⚠
- p.Pro344Leu Single submitter ⚠
- p.Pro347Leu Single submitter ⚠
- p.Pro375Leu Single submitter ⚠
- p.Pro383Arg Single submitter ⚠
- p.Pro38His Single submitter ⚠
- p.Pro44Ser Single submitter ⚠
- p.Pro72Thr Single submitter ⚠
- p.Pro76Ala Single submitter ⚠
- p.Pro76Thr Single submitter ⚠
- p.Pro77Ala Single submitter ⚠
- p.Pro95Thr Single submitter ⚠
- p.Ser124Thr Single submitter ⚠
- p.Ser162Leu Single submitter ⚠
- p.Ser169Leu Single submitter ⚠
- p.Ser17Phe Single submitter ⚠
- p.Ser335Arg Single submitter ⚠
- p.Ser394Phe Single submitter ⚠
- p.Ser478Thr Single submitter ⚠
- p.Ser56Asn Single submitter ⚠
- p.Thr349Ile Single submitter ⚠
- p.Thr433Ala Single submitter ⚠
- p.Trp20Leu Single submitter ⚠
- p.Trp20Ser Single submitter ⚠
- p.Tyr145Cys Single submitter ⚠
- p.Tyr145His Single submitter ⚠
- p.Tyr225Asp Single submitter ⚠
- p.Tyr477Asn Single submitter ⚠
- p.Tyr477Cys Single submitter ⚠
- p.Val255Leu Single submitter ⚠
- p.Val7Ile Single submitter ⚠