EID3 — 57 ClinVar variants
All ClinVar germline EID3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
2 Likely benign · 55 Uncertain significance
Full EID3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EID3 p.Ala216Val Uncertain significance Single submitter
- EID3 p.Ala319Val Uncertain significance Single submitter
- EID3 p.Ala62Val Uncertain significance Single submitter
- EID3 p.Ala90Val Uncertain significance Single submitter
- EID3 p.Ala9Pro Uncertain significance Single submitter
- EID3 p.Arg55Pro Uncertain significance Single submitter
- EID3 p.Asn115Asp Uncertain significance Single submitter
- EID3 p.Asn316Asp Uncertain significance Single submitter
- EID3 p.Cys142Trp Uncertain significance Single submitter
- EID3 p.Gln116Arg Uncertain significance Single submitter
- EID3 p.Glu222Lys Uncertain significance Single submitter
- EID3 p.Glu68Gln Uncertain significance Single submitter
- EID3 p.Glu72Lys Uncertain significance Single submitter
- EID3 p.Glu85Asp Uncertain significance Single submitter
- EID3 p.Gly11Asp Uncertain significance Single submitter
- EID3 p.Gly11Ser Uncertain significance Single submitter
- EID3 p.Gly294Ala Uncertain significance Single submitter
- EID3 p.Gly294Arg Uncertain significance Single submitter
- EID3 p.Ile282Val Uncertain significance Single submitter
- EID3 p.Ile307Leu Uncertain significance Single submitter
- EID3 p.Ile307Val Uncertain significance Single submitter
- EID3 p.Ile317Val Uncertain significance Single submitter
- EID3 p.Leu129Met Uncertain significance Single submitter
- EID3 p.Leu16Arg Uncertain significance Single submitter
- EID3 p.Lys105Thr Uncertain significance Single submitter
- EID3 p.Lys194Arg Uncertain significance Single submitter
- EID3 p.Met201Val Uncertain significance Single submitter
- EID3 p.Phe113Leu Uncertain significance Single submitter
- EID3 p.Phe122Cys Uncertain significance Single submitter
- EID3 p.Phe122Ser Uncertain significance Single submitter
- EID3 p.Phe252Leu Uncertain significance Single submitter
- EID3 p.Pro182Ser Uncertain significance Single submitter
- EID3 p.Pro25Arg Uncertain significance Single submitter
- EID3 p.Pro285Ser Uncertain significance Single submitter
- EID3 p.Ser109Ala Uncertain significance Single submitter
- EID3 p.Trp314Cys Uncertain significance Single submitter
- EID3 p.Tyr213Phe Uncertain significance Single submitter
- EID3 p.Tyr49His Uncertain significance Single submitter
- EID3 p.Val23Leu Uncertain significance Single submitter
- EID3 p.Val266Leu Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- EID3 p.Ala153Pro Uncertain significance Single submitter
- EID3 p.Ala326Val Uncertain significance Single submitter
- EID3 p.Arg179Leu Uncertain significance Single submitter
- EID3 p.Arg38Cys Uncertain significance Single submitter
- EID3 p.Arg55Leu Uncertain significance Single submitter
- EID3 p.Asp121Tyr Uncertain significance Single submitter
- EID3 p.Glu178Gln Uncertain significance Single submitter
- EID3 p.Glu34Gly Uncertain significance Single submitter
- EID3 p.Glu72Val Uncertain significance Single submitter
- EID3 p.Leu27Arg Uncertain significance Single submitter
- EID3 p.Lys103Met Uncertain significance Single submitter
- EID3 p.Met48Arg Uncertain significance Single submitter
- EID3 p.Ser253Tyr Uncertain significance Single submitter
- EID3 p.Val221Ile Uncertain significance Single submitter
- EID3 p.Val318Leu Uncertain significance Single submitter
All EID3 variants
Likely benign 2
- p.Met3Val Single submitter
- p.Met48Ile Single submitter
Uncertain significance 55
- p.Ala153Pro Single submitter ⚠
- p.Ala216Val Single submitter ⚠
- p.Ala319Val Single submitter ⚠
- p.Ala326Val Single submitter ⚠
- p.Ala62Val Single submitter ⚠
- p.Ala90Val Single submitter ⚠
- p.Ala9Pro Single submitter ⚠
- p.Arg179Leu Single submitter ⚠
- p.Arg38Cys Single submitter ⚠
- p.Arg55Leu Single submitter ⚠
- p.Arg55Pro Single submitter ⚠
- p.Asn115Asp Single submitter ⚠
- p.Asn316Asp Single submitter ⚠
- p.Asp121Tyr Single submitter ⚠
- p.Cys142Trp Single submitter ⚠
- p.Gln116Arg Single submitter ⚠
- p.Glu178Gln Single submitter ⚠
- p.Glu222Lys Single submitter ⚠
- p.Glu34Gly Single submitter ⚠
- p.Glu68Gln Single submitter ⚠
- p.Glu72Lys Single submitter ⚠
- p.Glu72Val Single submitter ⚠
- p.Glu85Asp Single submitter ⚠
- p.Gly11Asp Single submitter ⚠
- p.Gly11Ser Single submitter ⚠
- p.Gly294Ala Single submitter ⚠
- p.Gly294Arg Single submitter ⚠
- p.Ile282Val Single submitter ⚠
- p.Ile307Leu Single submitter ⚠
- p.Ile307Val Single submitter ⚠
- p.Ile317Val Single submitter ⚠
- p.Leu129Met Single submitter ⚠
- p.Leu16Arg Single submitter ⚠
- p.Leu27Arg Single submitter ⚠
- p.Lys103Met Single submitter ⚠
- p.Lys105Thr Single submitter ⚠
- p.Lys194Arg Single submitter ⚠
- p.Met201Val Single submitter ⚠
- p.Met48Arg Single submitter ⚠
- p.Phe113Leu Single submitter ⚠
- p.Phe122Cys Single submitter ⚠
- p.Phe122Ser Single submitter ⚠
- p.Phe252Leu Single submitter ⚠
- p.Pro182Ser Single submitter ⚠
- p.Pro25Arg Single submitter ⚠
- p.Pro285Ser Single submitter ⚠
- p.Ser109Ala Single submitter ⚠
- p.Ser253Tyr Single submitter ⚠
- p.Trp314Cys Single submitter ⚠
- p.Tyr213Phe Single submitter ⚠
- p.Tyr49His Single submitter ⚠
- p.Val221Ile Single submitter ⚠
- p.Val23Leu Single submitter ⚠
- p.Val266Leu Single submitter ⚠
- p.Val318Leu Single submitter ⚠