EIF3C — 12 ClinVar variants
All ClinVar germline EIF3C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
1 Benign · 11 Uncertain significance
Full EIF3C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF3C p.Ala270Thr Uncertain significance Single submitter
- EIF3C p.Ala327Thr Uncertain significance Single submitter
- EIF3C p.Asn296Ser Uncertain significance Single submitter
- EIF3C p.Asp266Ala Uncertain significance Single submitter
- EIF3C p.Asp283Asn Uncertain significance Single submitter
- EIF3C p.Asp295Glu Uncertain significance Single submitter
- EIF3C p.Pro261Thr Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All EIF3C variants
Benign 1
- c.777-8G>T Multiple submitters
Uncertain significance 11
- p.Ala270Thr Single submitter ⚠
- p.Ala327Thr Single submitter ⚠
- p.Arg274Trp Single submitter ⚠
- p.Arg288Cys Single submitter ⚠
- p.Arg305Trp Single submitter ⚠
- p.Asn296Ser Single submitter ⚠
- p.Asp266Ala Single submitter ⚠
- p.Asp283Asn Single submitter ⚠
- p.Asp295Glu Single submitter ⚠
- p.Gly307Ala Single submitter ⚠
- p.Pro261Thr Single submitter ⚠