EIF3E — 13 ClinVar variants
All ClinVar germline EIF3E variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
13 Uncertain significance
Full EIF3E gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF3E p.Ala174Thr Uncertain significance Single submitter
- EIF3E p.Arg111Lys Uncertain significance Single submitter
- EIF3E p.Cys315Tyr Uncertain significance Single submitter
- EIF3E p.His12Pro Uncertain significance Single submitter
- EIF3E p.Lys193Arg Uncertain significance Single submitter
- EIF3E p.Val261Gly Uncertain significance Single submitter
- EIF3E p.Arg9Cys Uncertain significance No assertion criteria
Predictors split 5
The independent predictors disagree with each other — read with care.
All EIF3E variants
Uncertain significance 13
- p.Ala174Thr Single submitter ⚠
- p.Arg111Lys Single submitter ⚠
- p.Asp358His Single submitter
- p.Cys315Tyr Single submitter ⚠
- p.His12Pro Single submitter ⚠
- p.Lys193Arg Single submitter ⚠
- p.Lys279Glu Single submitter ⚠
- p.Phe220Leu Single submitter ⚠
- p.Phe25Val Single submitter ⚠
- p.Thr161Ile Single submitter ⚠
- p.Val19Gly Single submitter ⚠
- p.Val261Gly Single submitter ⚠
- p.Arg9Cys No assertion criteria ⚠