EIF3G — 34 ClinVar variants
All ClinVar germline EIF3G variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
1 Benign · 2 Likely benign · 31 Uncertain significance
Full EIF3G gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF3G p.Ala95Val Uncertain significance Single submitter
- EIF3G p.Arg290Cys Uncertain significance Single submitter
- EIF3G p.Asp22Tyr Uncertain significance Single submitter
- EIF3G p.Gln140His Uncertain significance Single submitter
- EIF3G p.Glu143Asp Uncertain significance Single submitter
- EIF3G p.Gly263Ser Uncertain significance Single submitter
- EIF3G p.Gly39Asp Uncertain significance Single submitter
- EIF3G p.Gly4Val Uncertain significance Single submitter
- EIF3G p.Ile60Val Uncertain significance Single submitter
- EIF3G p.Ile72Arg Uncertain significance Single submitter
- EIF3G p.Lys24Glu Uncertain significance Single submitter
- EIF3G p.Lys9Arg Uncertain significance Single submitter
- EIF3G p.Met128Thr Uncertain significance Single submitter
- EIF3G p.Pro35Ser Uncertain significance Single submitter
- EIF3G p.Pro45Ser Uncertain significance Single submitter
- EIF3G p.Ser223Gly Uncertain significance Single submitter
- EIF3G p.Ser223Thr Uncertain significance Single submitter
- EIF3G p.Ser8Leu Uncertain significance Single submitter
- EIF3G p.Thr206Met Uncertain significance Single submitter
- EIF3G p.Thr3Ile Uncertain significance Single submitter
- EIF3G p.Thr3Ser Uncertain significance Single submitter
- EIF3G p.Val59Phe Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- EIF3G p.Ala239Thr Uncertain significance Single submitter
- EIF3G p.Glu201Lys Uncertain significance Single submitter
- EIF3G p.Glu248Asp Uncertain significance Single submitter
- EIF3G p.Gly114Arg Uncertain significance Single submitter
- EIF3G p.Phe6Leu Uncertain significance Single submitter
- EIF3G p.Pro197Leu Uncertain significance Single submitter
- EIF3G p.Tyr213Asn Uncertain significance Single submitter
- EIF3G p.Val96Ala Uncertain significance Single submitter
All EIF3G variants
Benign 1
- p.Phe282= Multiple submitters
Likely benign 2
- p.Asn208Ser Single submitter
- p.Glu201Asp Single submitter
Uncertain significance 31
- c.947+2dup Single submitter EIF3G-related autism spectrum disorder
- p.Ala239Thr Single submitter ⚠
- p.Ala95Val Single submitter ⚠
- p.Arg290Cys Single submitter ⚠
- p.Asp22Tyr Single submitter ⚠
- p.Gln140His Single submitter ⚠
- p.Glu143Asp Single submitter ⚠
- p.Glu201Lys Single submitter ⚠
- p.Glu248Asp Single submitter ⚠
- p.Gly114Arg Single submitter ⚠
- p.Gly263Ser Single submitter ⚠
- p.Gly39Asp Single submitter ⚠
- p.Gly4Val Single submitter ⚠
- p.Ile60Val Single submitter ⚠
- p.Ile72Arg Single submitter ⚠
- p.Lys24Glu Single submitter ⚠
- p.Lys9Arg Single submitter ⚠
- p.Met128Thr Single submitter ⚠
- p.Phe6Leu Single submitter ⚠
- p.Pro197Leu Single submitter ⚠
- p.Pro35Ser Single submitter ⚠
- p.Pro45Ser Single submitter ⚠
- p.Ser223Gly Single submitter ⚠
- p.Ser223Thr Single submitter ⚠
- p.Ser8Leu Single submitter ⚠
- p.Thr206Met Single submitter ⚠
- p.Thr3Ile Single submitter ⚠
- p.Thr3Ser Single submitter ⚠
- p.Tyr213Asn Single submitter ⚠
- p.Val59Phe Single submitter ⚠
- p.Val96Ala Single submitter ⚠