EIF3I — 15 ClinVar variants
All ClinVar germline EIF3I variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
1 Benign · 14 Uncertain significance
Full EIF3I gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF3I p.Ala206Thr Uncertain significance Single submitter
- EIF3I p.Arg77His Uncertain significance Single submitter
- EIF3I p.Asn192Ser Uncertain significance Single submitter
- EIF3I p.Cys160Arg Uncertain significance Single submitter
- EIF3I p.Ile108Thr Uncertain significance Single submitter
- EIF3I p.Leu89Phe Uncertain significance Single submitter
- EIF3I p.Lys298Arg Uncertain significance Single submitter
- EIF3I p.Met140Thr Uncertain significance Single submitter
- EIF3I p.Pro130Arg Uncertain significance Single submitter
- EIF3I p.Pro239His Uncertain significance Single submitter
- EIF3I p.Ser238Phe Uncertain significance Single submitter
- EIF3I p.Thr83Ile Uncertain significance Single submitter
- EIF3I p.Val204Leu Uncertain significance Single submitter
All EIF3I variants
Benign 1
- c.803+10A>G Multiple submitters
Uncertain significance 14
- p.Ala206Thr Single submitter ⚠
- p.Arg77His Single submitter ⚠
- p.Asn192Ser Single submitter ⚠
- p.Cys160Arg Single submitter ⚠
- p.Ile108Thr Single submitter ⚠
- p.Leu89Phe Single submitter ⚠
- p.Lys298Arg Single submitter ⚠
- p.Met140Thr Single submitter ⚠
- p.Met1Val Single submitter
- p.Pro130Arg Single submitter ⚠
- p.Pro239His Single submitter ⚠
- p.Ser238Phe Single submitter ⚠
- p.Thr83Ile Single submitter ⚠
- p.Val204Leu Single submitter ⚠