EIF3J — 15 ClinVar variants
All ClinVar germline EIF3J variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
15 Uncertain significance
Full EIF3J gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF3J p.Ala4Ser Uncertain significance Single submitter
- EIF3J p.Asp23Asn Uncertain significance Single submitter
- EIF3J p.Glu61Gln Uncertain significance Single submitter
- EIF3J p.Glu94Asp Uncertain significance Single submitter
- EIF3J p.Leu118Met Uncertain significance Single submitter
- EIF3J p.Lys121Arg Uncertain significance Single submitter
- EIF3J p.Lys27Met Uncertain significance Single submitter
- EIF3J p.Pro105Thr Uncertain significance Single submitter
- EIF3J p.Ser178Arg Uncertain significance Single submitter
- EIF3J p.Thr235Asn Uncertain significance Single submitter
- EIF3J p.Tyr143His Uncertain significance Single submitter
- EIF3J p.Val107Ala Uncertain significance Single submitter
- EIF3J p.Val187Leu Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All EIF3J variants
Uncertain significance 15
- p.Ala4Ser Single submitter ⚠
- p.Arg119Gln Single submitter ⚠
- p.Asp23Asn Single submitter ⚠
- p.Glu61Gln Single submitter ⚠
- p.Glu94Asp Single submitter ⚠
- p.Leu118Met Single submitter ⚠
- p.Lys121Arg Single submitter ⚠
- p.Lys27Met Single submitter ⚠
- p.Pro105Leu Single submitter ⚠
- p.Pro105Thr Single submitter ⚠
- p.Ser178Arg Single submitter ⚠
- p.Thr235Asn Single submitter ⚠
- p.Tyr143His Single submitter ⚠
- p.Val107Ala Single submitter ⚠
- p.Val187Leu Single submitter ⚠