EIF3K — 35 ClinVar variants
All ClinVar germline EIF3K variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
35 Uncertain significance
Full EIF3K gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF3K p.Ala116Ser Uncertain significance Single submitter
- EIF3K p.Arg155Cys Uncertain significance Single submitter
- EIF3K p.Arg155His Uncertain significance Single submitter
- EIF3K p.Arg97Gln Uncertain significance Single submitter
- EIF3K p.Asn200Ser Uncertain significance Single submitter
-
EIF3K p.Asp43Gly
Uncertain significance
Single submitter
EIF3K related disorder
- EIF3K p.Gly106Arg Uncertain significance Single submitter
- EIF3K p.Ile131Thr Uncertain significance Single submitter
- EIF3K p.Leu162Phe Uncertain significance Single submitter
- EIF3K p.Leu170Val Uncertain significance Single submitter
- EIF3K p.Lys171Arg Uncertain significance Single submitter
- EIF3K p.Met125Val Uncertain significance Single submitter
- EIF3K p.Met3Val Uncertain significance Single submitter
- EIF3K p.Phe4Ser Uncertain significance Single submitter
- EIF3K p.Pro78Ala Uncertain significance Single submitter
- EIF3K p.Ser137Cys Uncertain significance Single submitter
- EIF3K p.Ser180Asn Uncertain significance Single submitter
- EIF3K p.Ser195Asn Uncertain significance Single submitter
- EIF3K p.Trp173Cys Uncertain significance Single submitter
- EIF3K p.Val11Gly Uncertain significance Single submitter
- EIF3K p.Val146Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- EIF3K p.Ala215Val Uncertain significance Single submitter
- EIF3K p.Ala67Thr Uncertain significance Single submitter
- EIF3K p.Asn47Ser Uncertain significance Single submitter
- EIF3K p.Asn76Lys Uncertain significance Single submitter
- EIF3K p.Asp164Val Uncertain significance Single submitter
- EIF3K p.Gln94Glu Uncertain significance Single submitter
- EIF3K p.Glu135Lys Uncertain significance Single submitter
- EIF3K p.Glu183Lys Uncertain significance Single submitter
- EIF3K p.Ile99Val Uncertain significance Single submitter
- EIF3K p.Leu48Val Uncertain significance Single submitter
- EIF3K p.Lys52Arg Uncertain significance Single submitter
- EIF3K p.Phe60Leu Uncertain significance Single submitter
- EIF3K p.Ser168Ile Uncertain significance Single submitter
- EIF3K p.Thr132Ile Uncertain significance Single submitter
All EIF3K variants
Uncertain significance 35
- p.Ala116Ser Single submitter ⚠
- p.Ala215Val Single submitter ⚠
- p.Ala67Thr Single submitter ⚠
- p.Arg155Cys Single submitter ⚠
- p.Arg155His Single submitter ⚠
- p.Arg97Gln Single submitter ⚠
- p.Asn200Ser Single submitter ⚠
- p.Asn47Ser Single submitter ⚠
- p.Asn76Lys Single submitter ⚠
- p.Asp164Val Single submitter ⚠
- p.Asp43Gly Single submitter EIF3K related disorder ⚠
- p.Gln94Glu Single submitter ⚠
- p.Glu135Lys Single submitter ⚠
- p.Glu183Lys Single submitter ⚠
- p.Gly106Arg Single submitter ⚠
- p.Ile131Thr Single submitter ⚠
- p.Ile99Val Single submitter ⚠
- p.Leu162Phe Single submitter ⚠
- p.Leu170Val Single submitter ⚠
- p.Leu48Val Single submitter ⚠
- p.Lys171Arg Single submitter ⚠
- p.Lys52Arg Single submitter ⚠
- p.Met125Val Single submitter ⚠
- p.Met3Val Single submitter ⚠
- p.Phe4Ser Single submitter ⚠
- p.Phe60Leu Single submitter ⚠
- p.Pro78Ala Single submitter ⚠
- p.Ser137Cys Single submitter ⚠
- p.Ser168Ile Single submitter ⚠
- p.Ser180Asn Single submitter ⚠
- p.Ser195Asn Single submitter ⚠
- p.Thr132Ile Single submitter ⚠
- p.Trp173Cys Single submitter ⚠
- p.Val11Gly Single submitter ⚠
- p.Val146Met Single submitter ⚠