EIF3M — 28 ClinVar variants
All ClinVar germline EIF3M variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
28 Uncertain significance
Full EIF3M gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF3M p.Ala136Val Uncertain significance Single submitter
- EIF3M p.Arg94Cys Uncertain significance Single submitter
- EIF3M p.Arg94His Uncertain significance Single submitter
- EIF3M p.Arg98Cys Uncertain significance Single submitter
- EIF3M p.Asp264His Uncertain significance Single submitter
- EIF3M p.Asp77Asn Uncertain significance Single submitter
- EIF3M p.Glu95Lys Uncertain significance Single submitter
- EIF3M p.Ile292Val Uncertain significance Single submitter
- EIF3M p.Leu269Ser Uncertain significance Single submitter
- EIF3M p.Leu86Pro Uncertain significance Single submitter
- EIF3M p.Pro141Ala Uncertain significance Single submitter
- EIF3M p.Ser367Asn Uncertain significance Single submitter
- EIF3M p.Trp357Cys Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- EIF3M p.Arg166Ile Uncertain significance Single submitter
- EIF3M p.Asn108Lys Uncertain significance Single submitter
- EIF3M p.Asn360Lys Uncertain significance Single submitter
- EIF3M p.Glu17Ala Uncertain significance Single submitter
- EIF3M p.His339Arg Uncertain significance Single submitter
- EIF3M p.Ile45Thr Uncertain significance Single submitter
- EIF3M p.Leu188Val Uncertain significance Single submitter
- EIF3M p.Met283Thr Uncertain significance Single submitter
- EIF3M p.Met64Lys Uncertain significance Single submitter
- EIF3M p.Pro228Leu Uncertain significance Single submitter
- EIF3M p.Ser62Asn Uncertain significance Single submitter
- EIF3M p.Tyr21Cys Uncertain significance Single submitter
All EIF3M variants
Uncertain significance 28
- p.Ala136Val Single submitter ⚠
- p.Ala27Thr Single submitter
- p.Arg166Ile Single submitter ⚠
- p.Arg94Cys Single submitter ⚠
- p.Arg94His Single submitter ⚠
- p.Arg98Cys Single submitter ⚠
- p.Asn108Lys Single submitter ⚠
- p.Asn360Lys Single submitter ⚠
- p.Asp264His Single submitter ⚠
- p.Asp77Asn Single submitter ⚠
- p.Glu17Ala Single submitter ⚠
- p.Glu95Lys Single submitter ⚠
- p.His339Arg Single submitter ⚠
- p.His39fs Single submitter
- p.Ile292Val Single submitter ⚠
- p.Ile45Thr Single submitter ⚠
- p.Leu188Val Single submitter ⚠
- p.Leu269Ser Single submitter ⚠
- p.Leu86Pro Single submitter ⚠
- p.Met283Thr Single submitter ⚠
- p.Met64Lys Single submitter ⚠
- p.Pro141Ala Single submitter ⚠
- p.Pro228Leu Single submitter ⚠
- p.Ser367Asn Single submitter ⚠
- p.Ser62Asn Single submitter ⚠
- p.Ser66Gly Single submitter
- p.Trp357Cys Single submitter ⚠
- p.Tyr21Cys Single submitter ⚠