EIF4A1 — 16 ClinVar variants
All ClinVar germline EIF4A1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
1 Benign · 2 Likely benign · 13 Uncertain significance
Full EIF4A1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 7
The independent predictors disagree with each other — read with care.
- EIF4A1 p.Arg233Gln Uncertain significance Single submitter
- EIF4A1 p.Arg247Cys Uncertain significance Single submitter
- EIF4A1 p.Gln148His Uncertain significance Single submitter
- EIF4A1 p.Glu95Gly Uncertain significance Single submitter
- EIF4A1 p.Ser7Phe Uncertain significance Single submitter
- EIF4A1 p.Thr351Ile Uncertain significance Single submitter
- EIF4A1 p.Val105Ile Uncertain significance Single submitter
All EIF4A1 variants
Benign 1
- p.Ser89= Multiple submitters
Uncertain significance 13
- c.769-8A>G Single submitter
- p.Arg233Gln Single submitter ⚠
- p.Arg247Cys Single submitter ⚠
- p.Asn12Ser Single submitter ⚠
- p.Gln148His Single submitter ⚠
- p.Glu18Asp Single submitter ⚠
- p.Glu95Gly Single submitter ⚠
- p.Met216Val Single submitter ⚠
- p.Ser4Arg Single submitter ⚠
- p.Ser7Phe Single submitter ⚠
- p.Thr351Ile Single submitter ⚠
- p.Val105Ile Single submitter ⚠
- p.Val120Ile Single submitter ⚠