EIF4B — 74 ClinVar variants
All ClinVar germline EIF4B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 72 flagged for review →
1 Likely benign · 73 Uncertain significance
Full EIF4B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 72
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF4B p.Ala204Gly Uncertain significance Single submitter
- EIF4B p.Ala493Thr Uncertain significance Single submitter
- EIF4B p.Ala65Ser Uncertain significance Single submitter
- EIF4B p.Arg202Cys Uncertain significance Single submitter
- EIF4B p.Arg227His Uncertain significance Single submitter
- EIF4B p.Arg232Trp Uncertain significance Single submitter
- EIF4B p.Arg273Trp Uncertain significance Single submitter
- EIF4B p.Arg401Trp Uncertain significance Single submitter
- EIF4B p.Arg415Gln Uncertain significance Single submitter
- EIF4B p.Arg438Gln Uncertain significance Single submitter
- EIF4B p.Arg89His Uncertain significance Single submitter
- EIF4B p.Asn436Thr Uncertain significance Single submitter
- EIF4B p.Asp531Gly Uncertain significance Single submitter
- EIF4B p.Asp602His Uncertain significance Single submitter
- EIF4B p.Asp86Asn Uncertain significance Single submitter
- EIF4B p.Glu519Gln Uncertain significance Single submitter
- EIF4B p.Glu603Gly Uncertain significance Single submitter
- EIF4B p.Glu611Gly Uncertain significance Single submitter
- EIF4B p.Glu611Lys Uncertain significance Single submitter
- EIF4B p.Gly26Ala Uncertain significance Single submitter
- EIF4B p.Gly541Arg Uncertain significance Single submitter
- EIF4B p.Gly550Glu Uncertain significance Single submitter
- EIF4B p.Gly606Arg Uncertain significance Single submitter
- EIF4B p.Ile112Val Uncertain significance Single submitter
- EIF4B p.Ile68Val Uncertain significance Single submitter
- EIF4B p.Lys511Arg Uncertain significance Single submitter
- EIF4B p.Lys566Arg Uncertain significance Single submitter
- EIF4B p.Pro213Thr Uncertain significance Single submitter
- EIF4B p.Pro467Arg Uncertain significance Single submitter
- EIF4B p.Pro514Gln Uncertain significance Single submitter
- EIF4B p.Ser131Gly Uncertain significance Single submitter
- EIF4B p.Ser131Thr Uncertain significance Single submitter
- EIF4B p.Ser276Thr Uncertain significance Single submitter
- EIF4B p.Ser418Leu Uncertain significance Single submitter
- EIF4B p.Ser462Phe Uncertain significance Single submitter
- EIF4B p.Ser589Ala Uncertain significance Single submitter
- EIF4B p.Thr205Ala Uncertain significance Single submitter
- EIF4B p.Thr32Ala Uncertain significance Single submitter
- EIF4B p.Thr420Ala Uncertain significance Single submitter
- EIF4B p.Tyr593His Uncertain significance Single submitter
- EIF4B p.Val598Leu Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- EIF4B p.Ala364Val Uncertain significance Single submitter
- EIF4B p.Ala5Val Uncertain significance Single submitter
- EIF4B p.Arg225Gln Uncertain significance Single submitter
- EIF4B p.Arg238Trp Uncertain significance Single submitter
- EIF4B p.Arg247Gln Uncertain significance Single submitter
- EIF4B p.Arg255Trp Uncertain significance Single submitter
- EIF4B p.Arg308Gln Uncertain significance Single submitter
- EIF4B p.Arg318Gln Uncertain significance Single submitter
- EIF4B p.Arg322Ser Uncertain significance Single submitter
- EIF4B p.Arg323His Uncertain significance Single submitter
- EIF4B p.Arg379Trp Uncertain significance Single submitter
- EIF4B p.Arg401Gln Uncertain significance Single submitter
- EIF4B p.Arg401Pro Uncertain significance Single submitter
- EIF4B p.Arg417Trp Uncertain significance Single submitter
- EIF4B p.Asp271Glu Uncertain significance Single submitter
- EIF4B p.Asp319Val Uncertain significance Single submitter
- EIF4B p.Glu441Gln Uncertain significance Single submitter
- EIF4B p.Glu481Asp Uncertain significance Single submitter
- EIF4B p.Gly295Arg Uncertain significance Single submitter
- EIF4B p.Gly509Trp Uncertain significance Single submitter
- EIF4B p.Ile360Val Uncertain significance Single submitter
- EIF4B p.Ile72Thr Uncertain significance Single submitter
- EIF4B p.Pro328Leu Uncertain significance Single submitter
- EIF4B p.Ser418Trp Uncertain significance Single submitter
- EIF4B p.Ser504Phe Uncertain significance Single submitter
- EIF4B p.Ser52Leu Uncertain significance Single submitter
- EIF4B p.Ser591Arg Uncertain significance Single submitter
- EIF4B p.Tyr241Cys Uncertain significance Single submitter
- EIF4B p.Tyr270Cys Uncertain significance Single submitter
- EIF4B p.Tyr298Cys Uncertain significance Single submitter
- EIF4B p.Val473Gly Uncertain significance Single submitter
All EIF4B variants
Likely benign 1
- p.Ala65= Single submitter
Uncertain significance 73
- p.Ala204Gly Single submitter ⚠
- p.Ala364Val Single submitter ⚠
- p.Ala493Thr Single submitter ⚠
- p.Ala5Val Single submitter ⚠
- p.Ala65Ser Single submitter ⚠
- p.Arg202Cys Single submitter ⚠
- p.Arg225Gln Single submitter ⚠
- p.Arg227His Single submitter ⚠
- p.Arg232Trp Single submitter ⚠
- p.Arg238Trp Single submitter ⚠
- p.Arg247Gln Single submitter ⚠
- p.Arg255Trp Single submitter ⚠
- p.Arg273Trp Single submitter ⚠
- p.Arg308Gln Single submitter ⚠
- p.Arg318Gln Single submitter ⚠
- p.Arg322Ser Single submitter ⚠
- p.Arg323His Single submitter ⚠
- p.Arg379Trp Single submitter ⚠
- p.Arg401Gln Single submitter ⚠
- p.Arg401Pro Single submitter ⚠
- p.Arg401Trp Single submitter ⚠
- p.Arg415Gln Single submitter ⚠
- p.Arg417Trp Single submitter ⚠
- p.Arg438Gln Single submitter ⚠
- p.Arg89His Single submitter ⚠
- p.Asn436Thr Single submitter ⚠
- p.Asp271Glu Single submitter ⚠
- p.Asp319Val Single submitter ⚠
- p.Asp531Gly Single submitter ⚠
- p.Asp59Asn Single submitter
- p.Asp602His Single submitter ⚠
- p.Asp86Asn Single submitter ⚠
- p.Glu441Gln Single submitter ⚠
- p.Glu481Asp Single submitter ⚠
- p.Glu519Gln Single submitter ⚠
- p.Glu603Gly Single submitter ⚠
- p.Glu611Gly Single submitter ⚠
- p.Glu611Lys Single submitter ⚠
- p.Gly26Ala Single submitter ⚠
- p.Gly295Arg Single submitter ⚠
- p.Gly509Trp Single submitter ⚠
- p.Gly541Arg Single submitter ⚠
- p.Gly550Glu Single submitter ⚠
- p.Gly606Arg Single submitter ⚠
- p.Ile112Val Single submitter ⚠
- p.Ile360Val Single submitter ⚠
- p.Ile68Val Single submitter ⚠
- p.Ile72Thr Single submitter ⚠
- p.Lys511Arg Single submitter ⚠
- p.Lys566Arg Single submitter ⚠
- p.Pro213Thr Single submitter ⚠
- p.Pro328Leu Single submitter ⚠
- p.Pro467Arg Single submitter ⚠
- p.Pro514Gln Single submitter ⚠
- p.Ser131Gly Single submitter ⚠
- p.Ser131Thr Single submitter ⚠
- p.Ser276Thr Single submitter ⚠
- p.Ser418Leu Single submitter ⚠
- p.Ser418Trp Single submitter ⚠
- p.Ser462Phe Single submitter ⚠
- p.Ser504Phe Single submitter ⚠
- p.Ser52Leu Single submitter ⚠
- p.Ser589Ala Single submitter ⚠
- p.Ser591Arg Single submitter ⚠
- p.Thr205Ala Single submitter ⚠
- p.Thr32Ala Single submitter ⚠
- p.Thr420Ala Single submitter ⚠
- p.Tyr241Cys Single submitter ⚠
- p.Tyr270Cys Single submitter ⚠
- p.Tyr298Cys Single submitter ⚠
- p.Tyr593His Single submitter ⚠
- p.Val473Gly Single submitter ⚠
- p.Val598Leu Single submitter ⚠