EIF4E1B — 37 ClinVar variants
All ClinVar germline EIF4E1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
4 Likely benign · 33 Uncertain significance
Full EIF4E1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF4E1B p.Ala226Val Uncertain significance Single submitter
- EIF4E1B p.Arg172Gly Uncertain significance Single submitter
- EIF4E1B p.Arg193Gly Uncertain significance Single submitter
- EIF4E1B p.Arg193Ser Uncertain significance Single submitter
- EIF4E1B p.Arg67Ser Uncertain significance Single submitter
- EIF4E1B p.Cys161Tyr Uncertain significance Single submitter
- EIF4E1B p.Glu10Val Uncertain significance Single submitter
- EIF4E1B p.Glu168Asp Uncertain significance Single submitter
- EIF4E1B p.Gly164Arg Uncertain significance Single submitter
- EIF4E1B p.Gly53Val Uncertain significance Single submitter
- EIF4E1B p.Lys34Asn Uncertain significance Single submitter
- EIF4E1B p.Phe240Ser Uncertain significance Single submitter
- EIF4E1B p.Val190Leu Uncertain significance Single submitter
- EIF4E1B p.Val201Met Uncertain significance Single submitter
- EIF4E1B p.Val6Leu Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- EIF4E1B p.Ala195Val Uncertain significance Single submitter
- EIF4E1B p.Arg134Trp Uncertain significance Single submitter
- EIF4E1B p.Arg147Ser Uncertain significance Single submitter
- EIF4E1B p.Arg153Trp Uncertain significance Single submitter
- EIF4E1B p.Arg206Gly Uncertain significance Single submitter
- EIF4E1B p.Arg206Leu Uncertain significance Single submitter
- EIF4E1B p.Glu19Lys Likely benign Single submitter
- EIF4E1B p.Gly213Ser Uncertain significance Single submitter
- EIF4E1B p.His170Pro Uncertain significance Single submitter
- EIF4E1B p.Ile220Thr Uncertain significance Single submitter
- EIF4E1B p.Lys90Asn Uncertain significance Single submitter
- EIF4E1B p.Lys90Glu Uncertain significance Single submitter
- EIF4E1B p.Pro216Ser Uncertain significance Single submitter
- EIF4E1B p.Pro63Leu Uncertain significance Single submitter
- EIF4E1B p.Ser44Phe Uncertain significance Single submitter
- EIF4E1B p.Thr158Met Uncertain significance Single submitter
- EIF4E1B p.Thr29Met Uncertain significance Single submitter
- EIF4E1B p.Val179Leu Uncertain significance Single submitter
- EIF4E1B p.Val94Ala Uncertain significance Single submitter
All EIF4E1B variants
Likely benign 4
- p.Gln124Glu Single submitter
- p.Glu19Lys Single submitter ⚠
- p.Ile163= Single submitter
- p.Thr51Met Single submitter
Uncertain significance 33
- p.Ala195Val Single submitter ⚠
- p.Ala226Val Single submitter ⚠
- p.Arg134Trp Single submitter ⚠
- p.Arg147Ser Single submitter ⚠
- p.Arg153Trp Single submitter ⚠
- p.Arg172Gly Single submitter ⚠
- p.Arg193Gly Single submitter ⚠
- p.Arg193Ser Single submitter ⚠
- p.Arg206Gly Single submitter ⚠
- p.Arg206Leu Single submitter ⚠
- p.Arg67Ser Single submitter ⚠
- p.Cys161Tyr Single submitter ⚠
- p.Glu10Val Single submitter ⚠
- p.Glu168Asp Single submitter ⚠
- p.Gly164Arg Single submitter ⚠
- p.Gly213Ser Single submitter ⚠
- p.Gly53Val Single submitter ⚠
- p.His170Pro Single submitter ⚠
- p.Ile220Thr Single submitter ⚠
- p.Lys34Asn Single submitter ⚠
- p.Lys90Asn Single submitter ⚠
- p.Lys90Glu Single submitter ⚠
- p.Phe240Ser Single submitter ⚠
- p.Pro216Ser Single submitter ⚠
- p.Pro63Leu Single submitter ⚠
- p.Ser44Phe Single submitter ⚠
- p.Thr158Met Single submitter ⚠
- p.Thr29Met Single submitter ⚠
- p.Val179Leu Single submitter ⚠
- p.Val190Leu Single submitter ⚠
- p.Val201Met Single submitter ⚠
- p.Val6Leu Single submitter ⚠
- p.Val94Ala Single submitter ⚠