EIF4E2 — 24 ClinVar variants
All ClinVar germline EIF4E2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
24 Uncertain significance
Full EIF4E2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF4E2 p.Arg103His Uncertain significance Single submitter
- EIF4E2 p.Arg146His Uncertain significance Single submitter
- EIF4E2 p.Arg174Cys Uncertain significance Single submitter
- EIF4E2 p.Arg197Gln Uncertain significance Single submitter
- EIF4E2 p.Arg197Trp Uncertain significance Single submitter
- EIF4E2 p.Arg231Gly Uncertain significance Single submitter
- EIF4E2 p.Arg241Gln Uncertain significance Single submitter
- EIF4E2 p.Arg241Trp Uncertain significance Single submitter
- EIF4E2 p.Asn19Ser Uncertain significance Single submitter
- EIF4E2 p.Asn3Tyr Uncertain significance Single submitter
- EIF4E2 p.Asp126Asn Uncertain significance Single submitter
- EIF4E2 p.Gln57His Uncertain significance Single submitter
- EIF4E2 p.Lys43Asn Uncertain significance Single submitter
- EIF4E2 p.Pro240Arg Uncertain significance Single submitter
- EIF4E2 p.Pro55Ser Uncertain significance Single submitter
- EIF4E2 p.Ser220Ile Uncertain significance Single submitter
- EIF4E2 p.Thr33Met Uncertain significance Single submitter
- EIF4E2 p.Val102Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- EIF4E2 p.Ala7Thr Uncertain significance Single submitter
- EIF4E2 p.Gly70Ser Uncertain significance Single submitter
- EIF4E2 p.Leu204Phe Uncertain significance Single submitter
- EIF4E2 p.Pro51Leu Uncertain significance Single submitter
- EIF4E2 p.Ser99Gly Uncertain significance Single submitter
- EIF4E2 p.Thr192Ile Uncertain significance Single submitter
All EIF4E2 variants
Uncertain significance 24
- p.Ala7Thr Single submitter ⚠
- p.Arg103His Single submitter ⚠
- p.Arg146His Single submitter ⚠
- p.Arg174Cys Single submitter ⚠
- p.Arg197Gln Single submitter ⚠
- p.Arg197Trp Single submitter ⚠
- p.Arg231Gly Single submitter ⚠
- p.Arg241Gln Single submitter ⚠
- p.Arg241Trp Single submitter ⚠
- p.Asn19Ser Single submitter ⚠
- p.Asn3Tyr Single submitter ⚠
- p.Asp126Asn Single submitter ⚠
- p.Gln57His Single submitter ⚠
- p.Gly70Ser Single submitter ⚠
- p.Leu204Phe Single submitter ⚠
- p.Lys43Asn Single submitter ⚠
- p.Pro240Arg Single submitter ⚠
- p.Pro51Leu Single submitter ⚠
- p.Pro55Ser Single submitter ⚠
- p.Ser220Ile Single submitter ⚠
- p.Ser99Gly Single submitter ⚠
- p.Thr192Ile Single submitter ⚠
- p.Thr33Met Single submitter ⚠
- p.Val102Ile Single submitter ⚠