EIF4G2 — 75 ClinVar variants
All ClinVar germline EIF4G2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
1 Benign · 3 Likely benign · 71 Uncertain significance
Full EIF4G2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF4G2 p.Ala150Val Uncertain significance Single submitter
- EIF4G2 p.Ala25Val Uncertain significance Single submitter
- EIF4G2 p.Ala340Val Uncertain significance Single submitter
- EIF4G2 p.Ala68Pro Uncertain significance Single submitter
- EIF4G2 p.Arg569Lys Uncertain significance Single submitter
- EIF4G2 p.Arg592Gly Uncertain significance Single submitter
- EIF4G2 p.Arg687Gly Uncertain significance Single submitter
- EIF4G2 p.Asn404His Uncertain significance Single submitter
- EIF4G2 p.Asn66Ser Uncertain significance Single submitter
- EIF4G2 p.Asp594Asn Uncertain significance Single submitter
- EIF4G2 p.Asp789His Uncertain significance Single submitter
- EIF4G2 p.Gln199Arg Uncertain significance Single submitter
- EIF4G2 p.Gln405His Uncertain significance Single submitter
- EIF4G2 p.Gln437His Uncertain significance Single submitter
- EIF4G2 p.Gln486Lys Uncertain significance Single submitter
- EIF4G2 p.Gln609Arg Uncertain significance Single submitter
- EIF4G2 p.Gln807Lys Uncertain significance Single submitter
- EIF4G2 p.Glu152Asp Uncertain significance Single submitter
- EIF4G2 p.Glu904Asp Uncertain significance Single submitter
- EIF4G2 p.Gly19Arg Uncertain significance Single submitter
- EIF4G2 p.Gly34Ser Uncertain significance Single submitter
- EIF4G2 p.His413Tyr Uncertain significance Single submitter
- EIF4G2 p.Ile214Thr Uncertain significance Single submitter
- EIF4G2 p.Ile472Val Uncertain significance Single submitter
- EIF4G2 p.Ile586Phe Uncertain significance Single submitter
- EIF4G2 p.Ile750Thr Uncertain significance Single submitter
- EIF4G2 p.Leu286Ser Uncertain significance Single submitter
- EIF4G2 p.Leu316Phe Uncertain significance Single submitter
- EIF4G2 p.Leu435Gln Uncertain significance Single submitter
- EIF4G2 p.Leu450Gln Uncertain significance Single submitter
- EIF4G2 p.Leu705Pro Uncertain significance Single submitter
- EIF4G2 p.Leu808Gln Uncertain significance Single submitter
- EIF4G2 p.Lys608Arg Uncertain significance Single submitter
- EIF4G2 p.Lys761Arg Uncertain significance Single submitter
- EIF4G2 p.Lys882Arg Uncertain significance Single submitter
- EIF4G2 p.Phe394Tyr Uncertain significance Single submitter
- EIF4G2 p.Phe728Leu Uncertain significance Single submitter
- EIF4G2 p.Pro488Ser Uncertain significance Single submitter
- EIF4G2 p.Pro539Leu Uncertain significance Single submitter
- EIF4G2 p.Pro630Ala Uncertain significance Single submitter
- EIF4G2 p.Ser16Ala Uncertain significance Single submitter
- EIF4G2 p.Ser420Leu Uncertain significance Single submitter
- EIF4G2 p.Ser443Asn Uncertain significance Single submitter
- EIF4G2 p.Ser448Pro Uncertain significance Single submitter
- EIF4G2 p.Ser601Gly Uncertain significance Single submitter
- EIF4G2 p.Ser602Tyr Uncertain significance Single submitter
- EIF4G2 p.Ser782Cys Uncertain significance Single submitter
- EIF4G2 p.Thr56Ala Uncertain significance Single submitter
- EIF4G2 p.Thr669Asn Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- EIF4G2 p.Arg241Ser Uncertain significance Single submitter
- EIF4G2 p.Arg54Gly Uncertain significance Single submitter
- EIF4G2 p.Arg649His Uncertain significance Single submitter
- EIF4G2 p.Asp594Gly Uncertain significance Single submitter
- EIF4G2 p.Cys97Phe Uncertain significance Single submitter
- EIF4G2 p.Gly370Glu Uncertain significance Single submitter
- EIF4G2 p.Gly382Arg Uncertain significance Single submitter
- EIF4G2 p.Ile5Asn Uncertain significance Single submitter
- EIF4G2 p.Leu98Phe Uncertain significance Single submitter
- EIF4G2 p.Met571Thr Uncertain significance Single submitter
- EIF4G2 p.Met858Ile Uncertain significance Single submitter
- EIF4G2 p.Phe351Leu Uncertain significance Single submitter
- EIF4G2 p.Phe646Leu Uncertain significance Single submitter
- EIF4G2 p.Pro379Ser Uncertain significance Single submitter
- EIF4G2 p.Ser593Arg Uncertain significance Single submitter
- EIF4G2 p.Ser653Leu Uncertain significance Single submitter
- EIF4G2 p.Tyr839Cys Uncertain significance Single submitter
All EIF4G2 variants
Benign 1
- p.Val625= Multiple submitters
Likely benign 3
- p.Asn566Ser Single submitter
- p.Lys108= Single submitter
- p.Ser36= Single submitter
Uncertain significance 71
- p.Ala150Val Single submitter ⚠
- p.Ala25Val Single submitter ⚠
- p.Ala340Val Single submitter ⚠
- p.Ala68Pro Single submitter ⚠
- p.Arg241Ser Single submitter ⚠
- p.Arg54Gly Single submitter ⚠
- p.Arg569Lys Single submitter ⚠
- p.Arg592Gly Single submitter ⚠
- p.Arg649His Single submitter ⚠
- p.Arg687Gly Single submitter ⚠
- p.Asn177fs Single submitter
- p.Asn404His Single submitter ⚠
- p.Asn66Ser Single submitter ⚠
- p.Asp594Asn Single submitter ⚠
- p.Asp594Gly Single submitter ⚠
- p.Asp789His Single submitter ⚠
- p.Cys97Phe Single submitter ⚠
- p.Gln199Arg Single submitter ⚠
- p.Gln405His Single submitter ⚠
- p.Gln437His Single submitter ⚠
- p.Gln486Lys Single submitter ⚠
- p.Gln609Arg Single submitter ⚠
- p.Gln628Ter Single submitter
- p.Gln807Lys Single submitter ⚠
- p.Glu152Asp Single submitter ⚠
- p.Glu598Val Single submitter
- p.Glu904Asp Single submitter ⚠
- p.Gly19Arg Single submitter ⚠
- p.Gly34Ser Single submitter ⚠
- p.Gly370Glu Single submitter ⚠
- p.Gly382Arg Single submitter ⚠
- p.His413Tyr Single submitter ⚠
- p.Ile214Thr Single submitter ⚠
- p.Ile472Val Single submitter ⚠
- p.Ile586Phe Single submitter ⚠
- p.Ile5Asn Single submitter ⚠
- p.Ile750Thr Single submitter ⚠
- p.Leu286Ser Single submitter ⚠
- p.Leu316Phe Single submitter ⚠
- p.Leu39= Single submitter
- p.Leu435Gln Single submitter ⚠
- p.Leu450Gln Single submitter ⚠
- p.Leu705Pro Single submitter ⚠
- p.Leu808Gln Single submitter ⚠
- p.Leu98Phe Single submitter ⚠
- p.Lys608Arg Single submitter ⚠
- p.Lys761Arg Single submitter ⚠
- p.Lys882Arg Single submitter ⚠
- p.Met571Thr Single submitter ⚠
- p.Met858Ile Single submitter ⚠
- p.Phe351Leu Single submitter ⚠
- p.Phe394Tyr Single submitter ⚠
- p.Phe646Leu Single submitter ⚠
- p.Phe728Leu Single submitter ⚠
- p.Pro379Ser Single submitter ⚠
- p.Pro488Ser Single submitter ⚠
- p.Pro539Leu Single submitter ⚠
- p.Pro630Ala Single submitter ⚠
- p.Ser16Ala Single submitter ⚠
- p.Ser420Leu Single submitter ⚠
- p.Ser443Asn Single submitter ⚠
- p.Ser448Pro Single submitter ⚠
- p.Ser593Arg Single submitter ⚠
- p.Ser601Gly Single submitter ⚠
- p.Ser602Tyr Single submitter ⚠
- p.Ser653Leu Single submitter ⚠
- p.Ser782Cys Single submitter ⚠
- p.Thr322Met Single submitter
- p.Thr56Ala Single submitter ⚠
- p.Thr669Asn Single submitter ⚠
- p.Tyr839Cys Single submitter ⚠