EIF4G3 — 184 ClinVar variants
All ClinVar germline EIF4G3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 164 flagged for review →
1 Likely pathogenic · 1 Benign/Likely benign · 12 Likely benign · 170 Uncertain significance
Full EIF4G3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 164
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 115
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF4G3 p.Ala1543Thr Uncertain significance Single submitter
- EIF4G3 p.Ala178Val Uncertain significance Single submitter
- EIF4G3 p.Ala258Thr Uncertain significance Single submitter
- EIF4G3 p.Ala261Gly Uncertain significance Single submitter
- EIF4G3 p.Ala352Val Uncertain significance Single submitter
- EIF4G3 p.Ala500Thr Uncertain significance Single submitter
- EIF4G3 p.Ala522Gly Uncertain significance Single submitter
- EIF4G3 p.Ala533Thr Uncertain significance Single submitter
- EIF4G3 p.Ala648Gly Uncertain significance Single submitter
- EIF4G3 p.Ala880Thr Uncertain significance Single submitter
- EIF4G3 p.Ala923Ser Uncertain significance Single submitter
- EIF4G3 p.Arg1226Gln Uncertain significance Single submitter
- EIF4G3 p.Arg1485Gln Uncertain significance Single submitter
- EIF4G3 p.Arg1585Gln Uncertain significance Single submitter
- EIF4G3 p.Arg332Pro Uncertain significance Single submitter
- EIF4G3 p.Arg571Gln Uncertain significance Single submitter
- EIF4G3 p.Arg634His Uncertain significance Single submitter
- EIF4G3 p.Arg725Gln Uncertain significance Single submitter
- EIF4G3 p.Arg729Gln Uncertain significance Single submitter
- EIF4G3 p.Arg929Lys Uncertain significance Single submitter
- EIF4G3 p.Asn1205Ser Uncertain significance Single submitter
- EIF4G3 p.Asn413His Uncertain significance Single submitter
- EIF4G3 p.Asn547Ile Uncertain significance Single submitter
- EIF4G3 p.Asn713Asp Uncertain significance Single submitter
- EIF4G3 p.Asp1218Glu Uncertain significance Single submitter
- EIF4G3 p.Asp355Asn Uncertain significance Single submitter
- EIF4G3 p.Asp388Asn Uncertain significance Single submitter
- EIF4G3 p.Asp534Ala Uncertain significance Single submitter
- EIF4G3 p.Asp616Glu Uncertain significance Single submitter
- EIF4G3 p.Gln144Pro Uncertain significance Single submitter
- EIF4G3 p.Gln302Pro Uncertain significance Single submitter
- EIF4G3 p.Gln556His Uncertain significance Single submitter
- EIF4G3 p.Gln606His Uncertain significance Single submitter
- EIF4G3 p.Glu1018Gly Uncertain significance Single submitter
- EIF4G3 p.Glu1228Gly Uncertain significance Single submitter
- EIF4G3 p.Glu1276Asp Uncertain significance Single submitter
- EIF4G3 p.Glu1510Lys Uncertain significance Single submitter
- EIF4G3 p.Glu246Gln Uncertain significance Single submitter
- EIF4G3 p.Glu298Lys Uncertain significance Single submitter
- EIF4G3 p.Glu317Gln Uncertain significance Single submitter
- EIF4G3 p.Glu451Ala Uncertain significance Single submitter
- EIF4G3 p.Glu628Asp Uncertain significance Single submitter
- EIF4G3 p.Glu638Gly Uncertain significance Single submitter
- EIF4G3 p.Gly304Asp Uncertain significance Single submitter
- EIF4G3 p.Gly645Glu Uncertain significance Single submitter
- EIF4G3 p.His1291Pro Uncertain significance Single submitter
- EIF4G3 p.Ile1015Thr Uncertain significance Single submitter
- EIF4G3 p.Ile1461Met Uncertain significance Single submitter
- EIF4G3 p.Ile180Val Uncertain significance Single submitter
- EIF4G3 p.Ile335Val Uncertain significance Single submitter
- EIF4G3 p.Ile348Val Uncertain significance Single submitter
- EIF4G3 p.Ile445Ser Uncertain significance Single submitter
- EIF4G3 p.Ile540Asn Uncertain significance Single submitter
- EIF4G3 p.Ile646Val Uncertain significance Single submitter
- EIF4G3 p.Ile712Met Uncertain significance Single submitter
- EIF4G3 p.Ile856Val Uncertain significance Single submitter
- EIF4G3 p.Leu1412Ile Uncertain significance Single submitter
- EIF4G3 p.Leu443Ser Uncertain significance Single submitter
- EIF4G3 p.Leu982Val Uncertain significance Single submitter
- EIF4G3 p.Lys1002Thr Uncertain significance Single submitter
- EIF4G3 p.Lys1281Glu Uncertain significance Single submitter
- EIF4G3 p.Lys1385Arg Uncertain significance Single submitter
- EIF4G3 p.Lys1475Glu Uncertain significance Single submitter
- EIF4G3 p.Lys1484Glu Uncertain significance Single submitter
- EIF4G3 p.Lys770Arg Uncertain significance Single submitter
- EIF4G3 p.Met1074Leu Uncertain significance Single submitter
- EIF4G3 p.Met1074Val Uncertain significance Single submitter
- EIF4G3 p.Met578Leu Uncertain significance Single submitter
- EIF4G3 p.Met719Leu Uncertain significance Single submitter
- EIF4G3 p.Phe349Leu Uncertain significance Single submitter
- EIF4G3 p.Phe688Tyr Uncertain significance Single submitter
- EIF4G3 p.Pro1081Ser Uncertain significance Single submitter
- EIF4G3 p.Pro10Ala Uncertain significance Single submitter
- EIF4G3 p.Pro1260Ser Uncertain significance Single submitter
- EIF4G3 p.Pro142Ala Uncertain significance Single submitter
- EIF4G3 p.Pro1466Arg Uncertain significance Single submitter
- EIF4G3 p.Pro1466Leu Uncertain significance Single submitter
- EIF4G3 p.Pro1516Ser Uncertain significance Single submitter
- EIF4G3 p.Pro1550Leu Uncertain significance Single submitter
- EIF4G3 p.Pro226Leu Uncertain significance Single submitter
- EIF4G3 p.Pro383Ser Uncertain significance Single submitter
- EIF4G3 p.Pro450Ala Uncertain significance Single submitter
- EIF4G3 p.Pro481Ser Uncertain significance Single submitter
- EIF4G3 p.Pro498Leu Uncertain significance Single submitter
- EIF4G3 p.Pro562Arg Uncertain significance Single submitter
- EIF4G3 p.Pro568Leu Uncertain significance Single submitter
- EIF4G3 p.Pro614Ser Uncertain significance Single submitter
- EIF4G3 p.Pro745Ser Uncertain significance Single submitter
- EIF4G3 p.Pro751Ser Uncertain significance Single submitter
- EIF4G3 p.Pro81Ser Uncertain significance Single submitter
- EIF4G3 p.Pro94Leu Uncertain significance Single submitter
- EIF4G3 p.Ser1130Asn Uncertain significance Single submitter
- EIF4G3 p.Ser1326Arg Uncertain significance Single submitter
- EIF4G3 p.Ser1463Ala Uncertain significance Single submitter
- EIF4G3 p.Ser1558Ala Uncertain significance Single submitter
- EIF4G3 p.Ser340Ala Uncertain significance Single submitter
- EIF4G3 p.Ser543Pro Uncertain significance Single submitter
- EIF4G3 p.Ser605Asn Uncertain significance Single submitter
- EIF4G3 p.Ser605Ile Uncertain significance Single submitter
- EIF4G3 p.Ser615Pro Uncertain significance Single submitter
- EIF4G3 p.Ser705Asn Uncertain significance Single submitter
- EIF4G3 p.Ser705Thr Uncertain significance Single submitter
- EIF4G3 p.Thr1021Ile Uncertain significance Single submitter
- EIF4G3 p.Thr1172Lys Uncertain significance Single submitter
- EIF4G3 p.Thr409Ile Uncertain significance Single submitter
- EIF4G3 p.Thr463Ile Uncertain significance Single submitter
- EIF4G3 p.Thr494Ala Uncertain significance Single submitter
- EIF4G3 p.Thr494Ser Uncertain significance Single submitter
- EIF4G3 p.Val1619Met Uncertain significance Single submitter
- EIF4G3 p.Val398Ala Uncertain significance Single submitter
- EIF4G3 p.Val418Asp Uncertain significance Single submitter
- EIF4G3 p.Val596Ala Uncertain significance Single submitter
- EIF4G3 p.Val620Leu Uncertain significance Single submitter
- EIF4G3 p.Arg943Trp Uncertain significance No assertion criteria
-
EIF4G3 p.Asp904Tyr
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 49
The independent predictors disagree with each other — read with care.
- EIF4G3 p.Met1383Thr Benign/Likely benign Multiple submitters
- EIF4G3 p.Ala1533Gly Uncertain significance Single submitter
- EIF4G3 p.Ala920Val Uncertain significance Single submitter
- EIF4G3 p.Arg1101Trp Uncertain significance Single submitter
- EIF4G3 p.Arg1148Trp Uncertain significance Single submitter
- EIF4G3 p.Arg1203Trp Uncertain significance Single submitter
- EIF4G3 p.Arg1392Thr Uncertain significance Single submitter
- EIF4G3 p.Arg571Trp Uncertain significance Single submitter
- EIF4G3 p.Arg720Pro Uncertain significance Single submitter
- EIF4G3 p.Arg729Gly Uncertain significance Single submitter
- EIF4G3 p.Arg870Gln Uncertain significance Single submitter
- EIF4G3 p.Arg8His Uncertain significance Single submitter
- EIF4G3 p.Asn1451Asp Uncertain significance Single submitter
- EIF4G3 p.Asp1464His Uncertain significance Single submitter
- EIF4G3 p.Asp1534Asn Uncertain significance Single submitter
- EIF4G3 p.Asp1640Gly Uncertain significance Single submitter
- EIF4G3 p.Asp534Tyr Uncertain significance Single submitter
- EIF4G3 p.Gln186Lys Uncertain significance Single submitter
- EIF4G3 p.Gln69Arg Uncertain significance Single submitter
- EIF4G3 p.Ile805Met Uncertain significance Single submitter
- EIF4G3 p.Leu1160Val Uncertain significance Single submitter
- EIF4G3 p.Leu1458Phe Uncertain significance Single submitter
- EIF4G3 p.Leu1508Val Uncertain significance Single submitter
- EIF4G3 p.Lys1421Arg Uncertain significance Single submitter
- EIF4G3 p.Lys899Asn Uncertain significance Single submitter
- EIF4G3 p.Met868Leu Uncertain significance Single submitter
- EIF4G3 p.Pro10Leu Uncertain significance Single submitter
- EIF4G3 p.Pro1165His Uncertain significance Single submitter
- EIF4G3 p.Pro133Leu Uncertain significance Single submitter
- EIF4G3 p.Pro137Leu Uncertain significance Single submitter
- EIF4G3 p.Pro146Leu Uncertain significance Single submitter
- EIF4G3 p.Pro157Ser Uncertain significance Single submitter
- EIF4G3 p.Pro173Leu Uncertain significance Single submitter
- EIF4G3 p.Pro188Leu Uncertain significance Single submitter
- EIF4G3 p.Pro703Arg Uncertain significance Single submitter
- EIF4G3 p.Pro728Leu Uncertain significance Single submitter
- EIF4G3 p.Pro735Ser Uncertain significance Single submitter
- EIF4G3 p.Pro81Leu Uncertain significance Single submitter
- EIF4G3 p.Pro94Ser Uncertain significance Single submitter
- EIF4G3 p.Ser1463Cys Uncertain significance Single submitter
- EIF4G3 p.Ser1463Tyr Uncertain significance Single submitter
- EIF4G3 p.Ser220Asn Uncertain significance Single submitter
- EIF4G3 p.Ser341Phe Uncertain significance Single submitter
- EIF4G3 p.Thr1169Met Uncertain significance Single submitter
- EIF4G3 p.Thr1172Met Uncertain significance Single submitter
- EIF4G3 p.Thr184Met Uncertain significance Single submitter
- EIF4G3 p.Thr233Ile Uncertain significance Single submitter
- EIF4G3 p.Val1094Leu Uncertain significance Single submitter
- EIF4G3 p.Val1526Ile Uncertain significance Single submitter
All EIF4G3 variants
Likely pathogenic 1
- p.Lys1609fs Single submitter heparin cofactor 2 deficiency
Benign/Likely benign 1
- p.Met1383Thr Multiple submitters ⚠
Likely benign 12
- c.-361GGC[14] Single submitter
- c.-361GGC[7] Single submitter
- c.-456+129A>C Single submitter
- c.-456+155T>G Single submitter
- p.Ala1634= Single submitter
- p.Gly1211Ser Single submitter
- p.Ile312= Single submitter
- p.Ile312Val Single submitter
- p.Ile353Val Single submitter
- p.Ile367Val Single submitter
- p.Leu1486= Single submitter
- p.Val313Ile Single submitter
Uncertain significance 170
- c.2253+798T>C Single submitter
- c.2253+860G>A Single submitter
- c.2253+863A>T Single submitter
- c.2253+869C>T Single submitter
- c.2253+879T>C Single submitter
- c.2253+885G>A Single submitter
- c.2253+894T>C Single submitter
- p.Ala1533Gly Single submitter ⚠
- p.Ala1543Thr Single submitter ⚠
- p.Ala178Val Single submitter ⚠
- p.Ala258Thr Single submitter ⚠
- p.Ala261Gly Single submitter ⚠
- p.Ala352Val Single submitter ⚠
- p.Ala500Thr Single submitter ⚠
- p.Ala522Gly Single submitter ⚠
- p.Ala533Thr Single submitter ⚠
- p.Ala648Gly Single submitter ⚠
- p.Ala880Thr Single submitter ⚠
- p.Ala920Val Single submitter ⚠
- p.Ala923Ser Single submitter ⚠
- p.Arg1101Trp Single submitter ⚠
- p.Arg1148Trp Single submitter ⚠
- p.Arg1203Trp Single submitter ⚠
- p.Arg1226Gln Single submitter ⚠
- p.Arg1392Thr Single submitter ⚠
- p.Arg1485Gln Single submitter ⚠
- p.Arg1585Gln Single submitter ⚠
- p.Arg332Pro Single submitter ⚠
- p.Arg571Gln Single submitter ⚠
- p.Arg571Trp Single submitter ⚠
- p.Arg634His Single submitter ⚠
- p.Arg720Pro Single submitter ⚠
- p.Arg725Gln Single submitter ⚠
- p.Arg729Gln Single submitter ⚠
- p.Arg729Gly Single submitter ⚠
- p.Arg870Gln Single submitter ⚠
- p.Arg8His Single submitter ⚠
- p.Arg929Lys Single submitter ⚠
- p.Asn1205Ser Single submitter ⚠
- p.Asn1451Asp Single submitter ⚠
- p.Asn413His Single submitter ⚠
- p.Asn547Ile Single submitter ⚠
- p.Asn713Asp Single submitter ⚠
- p.Asp1218Glu Single submitter ⚠
- p.Asp1464His Single submitter ⚠
- p.Asp1534Asn Single submitter ⚠
- p.Asp1640Gly Single submitter ⚠
- p.Asp355Asn Single submitter ⚠
- p.Asp388Asn Single submitter ⚠
- p.Asp534Ala Single submitter ⚠
- p.Asp534Tyr Single submitter ⚠
- p.Asp616Glu Single submitter ⚠
- p.Gln144Pro Single submitter ⚠
- p.Gln186Lys Single submitter ⚠
- p.Gln302Pro Single submitter ⚠
- p.Gln556His Single submitter ⚠
- p.Gln606His Single submitter ⚠
- p.Gln69Arg Single submitter ⚠
- p.Glu1018Gly Single submitter ⚠
- p.Glu1228Gly Single submitter ⚠
- p.Glu1276Asp Single submitter ⚠
- p.Glu1510Lys Single submitter ⚠
- p.Glu246Gln Single submitter ⚠
- p.Glu298Lys Single submitter ⚠
- p.Glu317Gln Single submitter ⚠
- p.Glu451Ala Single submitter ⚠
- p.Glu628Asp Single submitter ⚠
- p.Glu638Gly Single submitter ⚠
- p.Gly304Asp Single submitter ⚠
- p.Gly645Glu Single submitter ⚠
- p.His1291Pro Single submitter ⚠
- p.Ile1015Thr Single submitter ⚠
- p.Ile1461Met Single submitter ⚠
- p.Ile180Val Single submitter ⚠
- p.Ile335Val Single submitter ⚠
- p.Ile348Val Single submitter ⚠
- p.Ile445Ser Single submitter ⚠
- p.Ile540Asn Single submitter ⚠
- p.Ile646Val Single submitter ⚠
- p.Ile712Met Single submitter ⚠
- p.Ile805Met Single submitter ⚠
- p.Ile856Val Single submitter ⚠
- p.Leu1160Val Single submitter ⚠
- p.Leu1412Ile Single submitter ⚠
- p.Leu1458Phe Single submitter ⚠
- p.Leu1508Val Single submitter ⚠
- p.Leu443Ser Single submitter ⚠
- p.Leu982Val Single submitter ⚠
- p.Lys1002Thr Single submitter ⚠
- p.Lys1281Glu Single submitter ⚠
- p.Lys1385Arg Single submitter ⚠
- p.Lys1421Arg Single submitter ⚠
- p.Lys1475Glu Single submitter ⚠
- p.Lys1484Glu Single submitter ⚠
- p.Lys770Arg Single submitter ⚠
- p.Lys899Asn Single submitter ⚠
- p.Met1074Leu Single submitter ⚠
- p.Met1074Val Single submitter ⚠
- p.Met578Leu Single submitter ⚠
- p.Met719Leu Single submitter ⚠
- p.Met868Leu Single submitter ⚠
- p.Phe349Leu Single submitter ⚠
- p.Phe688Tyr Single submitter ⚠
- p.Pro1081Ser Single submitter ⚠
- p.Pro10Ala Single submitter ⚠
- p.Pro10Leu Single submitter ⚠
- p.Pro1165His Single submitter ⚠
- p.Pro1260Ser Single submitter ⚠
- p.Pro133Leu Single submitter ⚠
- p.Pro137Leu Single submitter ⚠
- p.Pro142Ala Single submitter ⚠
- p.Pro1466Arg Single submitter ⚠
- p.Pro1466Leu Single submitter ⚠
- p.Pro146Leu Single submitter ⚠
- p.Pro1516Ser Single submitter ⚠
- p.Pro1550Leu Single submitter ⚠
- p.Pro157Ser Single submitter ⚠
- p.Pro173Leu Single submitter ⚠
- p.Pro188Leu Single submitter ⚠
- p.Pro226Leu Single submitter ⚠
- p.Pro383Ser Single submitter ⚠
- p.Pro450Ala Single submitter ⚠
- p.Pro481Ser Single submitter ⚠
- p.Pro498Leu Single submitter ⚠
- p.Pro562Arg Single submitter ⚠
- p.Pro568Leu Single submitter ⚠
- p.Pro614Ser Single submitter ⚠
- p.Pro703Arg Single submitter ⚠
- p.Pro728Leu Single submitter ⚠
- p.Pro735Ser Single submitter ⚠
- p.Pro745Ser Single submitter ⚠
- p.Pro751Ser Single submitter ⚠
- p.Pro81Leu Single submitter ⚠
- p.Pro81Ser Single submitter ⚠
- p.Pro94Leu Single submitter ⚠
- p.Pro94Ser Single submitter ⚠
- p.Ser1130Asn Single submitter ⚠
- p.Ser1326Arg Single submitter ⚠
- p.Ser1463Ala Single submitter ⚠
- p.Ser1463Cys Single submitter ⚠
- p.Ser1463Tyr Single submitter ⚠
- p.Ser1558Ala Single submitter ⚠
- p.Ser220Asn Single submitter ⚠
- p.Ser340Ala Single submitter ⚠
- p.Ser341Phe Single submitter ⚠
- p.Ser543Pro Single submitter ⚠
- p.Ser605Asn Single submitter ⚠
- p.Ser605Ile Single submitter ⚠
- p.Ser615Pro Single submitter ⚠
- p.Ser705Asn Single submitter ⚠
- p.Ser705Thr Single submitter ⚠
- p.Thr1021Ile Single submitter ⚠
- p.Thr1169Met Single submitter ⚠
- p.Thr1172Lys Single submitter ⚠
- p.Thr1172Met Single submitter ⚠
- p.Thr184Met Single submitter ⚠
- p.Thr233Ile Single submitter ⚠
- p.Thr409Ile Single submitter ⚠
- p.Thr463Ile Single submitter ⚠
- p.Thr494Ala Single submitter ⚠
- p.Thr494Ser Single submitter ⚠
- p.Val1094Leu Single submitter ⚠
- p.Val1526Ile Single submitter ⚠
- p.Val1619Met Single submitter ⚠
- p.Val398Ala Single submitter ⚠
- p.Val418Asp Single submitter ⚠
- p.Val596Ala Single submitter ⚠
- p.Val620Leu Single submitter ⚠
- p.Arg943Trp No assertion criteria ⚠
- p.Asp904Tyr No assertion criteria prostate cancer ⚠