ELF3 — 23 ClinVar variants
All ClinVar germline ELF3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
1 Benign · 3 Likely benign · 19 Uncertain significance
Full ELF3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ELF3 p.Arg205Trp Uncertain significance Single submitter
- ELF3 p.Arg233Cys Uncertain significance Single submitter
- ELF3 p.Arg370Gln Uncertain significance Single submitter
- ELF3 p.Asp220Tyr Uncertain significance Single submitter
- ELF3 p.Asp234Asn Uncertain significance Single submitter
- ELF3 p.Asp96Glu Uncertain significance Single submitter
- ELF3 p.Glu290Lys Uncertain significance Single submitter
- ELF3 p.Leu154Val Uncertain significance Single submitter
- ELF3 p.Met148Ile Uncertain significance Single submitter
- ELF3 p.Pro181Leu Uncertain significance Single submitter
- ELF3 p.Pro189Leu Uncertain significance Single submitter
- ELF3 p.Thr54Lys Uncertain significance Single submitter
- ELF3 p.Trp59Leu Uncertain significance Single submitter
- ELF3 p.Val217Met Uncertain significance Single submitter
- ELF3 p.Val302Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All ELF3 variants
Benign 1
- p.Asn104= Multiple submitters
Likely benign 3
- p.Asp172= Single submitter
- p.Gly173Ser Single submitter
- p.Ser68= Single submitter
Uncertain significance 19
- p.Arg205Trp Single submitter ⚠
- p.Arg233Cys Single submitter ⚠
- p.Arg307His Single submitter ⚠
- p.Arg370Gln Single submitter ⚠
- p.Arg370Trp Single submitter ⚠
- p.Asp220Tyr Single submitter ⚠
- p.Asp234Asn Single submitter ⚠
- p.Asp96Glu Single submitter ⚠
- p.Cys5Arg Single submitter ⚠
- p.Glu290Lys Single submitter ⚠
- p.Leu154Val Single submitter ⚠
- p.Met148Ile Single submitter ⚠
- p.Pro181Leu Single submitter ⚠
- p.Pro189Leu Single submitter ⚠
- p.Ser193Asn Single submitter ⚠
- p.Thr54Lys Single submitter ⚠
- p.Trp59Leu Single submitter ⚠
- p.Val217Met Single submitter ⚠
- p.Val302Ile Single submitter ⚠