ELK3 — 64 ClinVar variants
All ClinVar germline ELK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
3 Benign · 2 Likely benign · 59 Uncertain significance
Full ELK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ELK3 p.Ala121Thr Uncertain significance Single submitter
- ELK3 p.Ala157Thr Uncertain significance Single submitter
- ELK3 p.Ala208Val Uncertain significance Single submitter
- ELK3 p.Ala215Thr Uncertain significance Single submitter
- ELK3 p.Ala236Ser Uncertain significance Single submitter
- ELK3 p.Ala236Val Uncertain significance Single submitter
- ELK3 p.Ala263Thr Uncertain significance Single submitter
- ELK3 p.Ala264Val Uncertain significance Single submitter
- ELK3 p.Ala291Val Uncertain significance Single submitter
- ELK3 p.Ala333Thr Uncertain significance Single submitter
- ELK3 p.Ala360Gly Uncertain significance Single submitter
- ELK3 p.Ala365Thr Uncertain significance Single submitter
- ELK3 p.Arg102Gln Uncertain significance Single submitter
- ELK3 p.Arg102Leu Uncertain significance Single submitter
- ELK3 p.Arg119His Uncertain significance Single submitter
- ELK3 p.Arg257Thr Uncertain significance Single submitter
- ELK3 p.Asp111Asn Uncertain significance Single submitter
- ELK3 p.Cys265Gly Uncertain significance Single submitter
- ELK3 p.Glu206Ala Uncertain significance Single submitter
- ELK3 p.Gly125Arg Uncertain significance Single submitter
- ELK3 p.Gly125Ser Uncertain significance Single submitter
- ELK3 p.Gly308Ser Uncertain significance Single submitter
- ELK3 p.Gly312Ser Uncertain significance Single submitter
- ELK3 p.Gly338Val Uncertain significance Single submitter
- ELK3 p.His20Leu Uncertain significance Single submitter
- ELK3 p.His383Gln Uncertain significance Single submitter
- ELK3 p.Ile222Val Uncertain significance Single submitter
- ELK3 p.Ile388Val Uncertain significance Single submitter
- ELK3 p.Ile76Met Uncertain significance Single submitter
- ELK3 p.Ile90Met Uncertain significance Single submitter
- ELK3 p.Leu201Pro Uncertain significance Single submitter
- ELK3 p.Leu201Val Uncertain significance Single submitter
- ELK3 p.Leu252Phe Uncertain significance Single submitter
- ELK3 p.Met226Leu Uncertain significance Single submitter
- ELK3 p.Pro116Leu Uncertain significance Single submitter
- ELK3 p.Pro174Ala Uncertain significance Single submitter
- ELK3 p.Pro174Ser Uncertain significance Single submitter
- ELK3 p.Pro202Ser Uncertain significance Single submitter
- ELK3 p.Pro285Leu Uncertain significance Single submitter
- ELK3 p.Pro289Ala Uncertain significance Single submitter
- ELK3 p.Pro397Leu Uncertain significance Single submitter
- ELK3 p.Ser110Gly Uncertain significance Single submitter
- ELK3 p.Ser203Phe Uncertain significance Single submitter
- ELK3 p.Ser223Ala Uncertain significance Single submitter
- ELK3 p.Ser258Gly Uncertain significance Single submitter
- ELK3 p.Ser270Phe Uncertain significance Single submitter
- ELK3 p.Ser278Ala Uncertain significance Single submitter
- ELK3 p.Ser286Phe Uncertain significance Single submitter
- ELK3 p.Ser404Pro Uncertain significance Single submitter
- ELK3 p.Thr163Met Uncertain significance Single submitter
- ELK3 p.Thr309Ile Uncertain significance Single submitter
- ELK3 p.Thr332Ala Uncertain significance Single submitter
- ELK3 p.Thr372Met Uncertain significance Single submitter
- ELK3 p.Val218Leu Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All ELK3 variants
Benign 3
- p.Pro343= Multiple submitters
- p.Ser278= Multiple submitters
- c.1125+7G>A Single submitter
Likely benign 2
- p.Thr204Met Multiple submitters
- p.Met226Ile Single submitter
Uncertain significance 59
- p.Ala121Thr Single submitter ⚠
- p.Ala157Thr Single submitter ⚠
- p.Ala208Val Single submitter ⚠
- p.Ala215Thr Single submitter ⚠
- p.Ala236Ser Single submitter ⚠
- p.Ala236Val Single submitter ⚠
- p.Ala263Thr Single submitter ⚠
- p.Ala264Val Single submitter ⚠
- p.Ala291Val Single submitter ⚠
- p.Ala333Thr Single submitter ⚠
- p.Ala360Gly Single submitter ⚠
- p.Ala365Thr Single submitter ⚠
- p.Ala4Val Single submitter ⚠
- p.Arg102Gln Single submitter ⚠
- p.Arg102Leu Single submitter ⚠
- p.Arg119His Single submitter ⚠
- p.Arg184Gly Single submitter ⚠
- p.Arg257Thr Single submitter ⚠
- p.Asn381Lys Single submitter ⚠
- p.Asp111Asn Single submitter ⚠
- p.Cys265Gly Single submitter ⚠
- p.Glu206Ala Single submitter ⚠
- p.Gly125Arg Single submitter ⚠
- p.Gly125Ser Single submitter ⚠
- p.Gly308Ser Single submitter ⚠
- p.Gly312Ser Single submitter ⚠
- p.Gly338Val Single submitter ⚠
- p.His20Leu Single submitter ⚠
- p.His383Gln Single submitter ⚠
- p.Ile222Val Single submitter ⚠
- p.Ile388Val Single submitter ⚠
- p.Ile76Met Single submitter ⚠
- p.Ile90Met Single submitter ⚠
- p.Leu201Pro Single submitter ⚠
- p.Leu201Val Single submitter ⚠
- p.Leu252Phe Single submitter ⚠
- p.Leu346Pro Single submitter ⚠
- p.Met226Leu Single submitter ⚠
- p.Pro116Leu Single submitter ⚠
- p.Pro174Ala Single submitter ⚠
- p.Pro174Ser Single submitter ⚠
- p.Pro202Ser Single submitter ⚠
- p.Pro285Leu Single submitter ⚠
- p.Pro289Ala Single submitter ⚠
- p.Pro303Leu Single submitter ⚠
- p.Pro397Leu Single submitter ⚠
- p.Ser110Gly Single submitter ⚠
- p.Ser203Phe Single submitter ⚠
- p.Ser223Ala Single submitter ⚠
- p.Ser258Gly Single submitter ⚠
- p.Ser270Phe Single submitter ⚠
- p.Ser278Ala Single submitter ⚠
- p.Ser286Phe Single submitter ⚠
- p.Ser404Pro Single submitter ⚠
- p.Thr163Met Single submitter ⚠
- p.Thr309Ile Single submitter ⚠
- p.Thr332Ala Single submitter ⚠
- p.Thr372Met Single submitter ⚠
- p.Val218Leu Single submitter ⚠