ELK4 — 54 ClinVar variants
All ClinVar germline ELK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
2 Likely benign · 52 Uncertain significance
Full ELK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ELK4 p.Arg48Cys Uncertain significance Single submitter
- ELK4 p.Asn159Ser Uncertain significance Single submitter
- ELK4 p.Asn295Ser Uncertain significance Single submitter
- ELK4 p.Asp119Asn Uncertain significance Single submitter
- ELK4 p.Cys105Ser Uncertain significance Single submitter
- ELK4 p.Glu106Gln Uncertain significance Single submitter
- ELK4 p.Glu173Lys Uncertain significance Single submitter
- ELK4 p.Glu202Gln Uncertain significance Single submitter
- ELK4 p.Gly123Arg Uncertain significance Single submitter
- ELK4 p.Ile214Thr Uncertain significance Single submitter
- ELK4 p.Ile214Val Uncertain significance Single submitter
- ELK4 p.Ile282Val Uncertain significance Single submitter
- ELK4 p.Ile363Phe Uncertain significance Single submitter
- ELK4 p.Leu175Met Uncertain significance Single submitter
- ELK4 p.Leu225Phe Uncertain significance Single submitter
- ELK4 p.Leu386Val Uncertain significance Single submitter
- ELK4 p.Lys127Glu Uncertain significance Single submitter
- ELK4 p.Lys179Ile Uncertain significance Single submitter
- ELK4 p.Lys190Arg Uncertain significance Single submitter
- ELK4 p.Lys310Glu Uncertain significance Single submitter
- ELK4 p.Lys323Arg Uncertain significance Single submitter
- ELK4 p.Lys323Glu Uncertain significance Single submitter
- ELK4 p.Lys34Arg Uncertain significance Single submitter
- ELK4 p.Met246Val Uncertain significance Single submitter
- ELK4 p.Met290Ile Uncertain significance Single submitter
- ELK4 p.Met290Val Uncertain significance Single submitter
- ELK4 p.Pro129Leu Uncertain significance Single submitter
- ELK4 p.Pro18Thr Uncertain significance Single submitter
- ELK4 p.Pro260Thr Uncertain significance Single submitter
- ELK4 p.Pro289Arg Uncertain significance Single submitter
- ELK4 p.Pro293Arg Uncertain significance Single submitter
- ELK4 p.Ser215Cys Uncertain significance Single submitter
- ELK4 p.Ser284Leu Uncertain significance Single submitter
- ELK4 p.Ser287Pro Uncertain significance Single submitter
- ELK4 p.Ser347Pro Uncertain significance Single submitter
- ELK4 p.Ser86Phe Uncertain significance Single submitter
- ELK4 p.Thr193Met Uncertain significance Single submitter
- ELK4 p.Thr240Ile Uncertain significance Single submitter
- ELK4 p.Thr267Ile Uncertain significance Single submitter
- ELK4 p.Thr350Ile Uncertain significance Single submitter
- ELK4 p.Thr97Arg Uncertain significance Single submitter
- ELK4 p.Val229Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- ELK4 p.Ala384Val Uncertain significance Single submitter
- ELK4 p.Asn20Lys Uncertain significance Single submitter
- ELK4 p.Pro322Arg Uncertain significance Single submitter
- ELK4 p.Pro349Arg Uncertain significance Single submitter
- ELK4 p.Ser345Asn Uncertain significance Single submitter
- ELK4 p.Ser406Cys Uncertain significance Single submitter
- ELK4 p.Ser425Phe Uncertain significance Single submitter
All ELK4 variants
Likely benign 2
- p.Pro259Ser Single submitter
- p.Thr247Ala Single submitter
Uncertain significance 52
- p.Ala384Val Single submitter ⚠
- p.Arg48Cys Single submitter ⚠
- p.Arg48His Single submitter
- p.Asn159Ser Single submitter ⚠
- p.Asn20Lys Single submitter ⚠
- p.Asn295Ser Single submitter ⚠
- p.Asp119Asn Single submitter ⚠
- p.Cys105Ser Single submitter ⚠
- p.Gln13His Single submitter
- p.Glu106Gln Single submitter ⚠
- p.Glu173Lys Single submitter ⚠
- p.Glu202Gln Single submitter ⚠
- p.Gly123Arg Single submitter ⚠
- p.Ile214Thr Single submitter ⚠
- p.Ile214Val Single submitter ⚠
- p.Ile282Val Single submitter ⚠
- p.Ile363Phe Single submitter ⚠
- p.Leu175Met Single submitter ⚠
- p.Leu225Phe Single submitter ⚠
- p.Leu386Val Single submitter ⚠
- p.Lys127Glu Single submitter ⚠
- p.Lys179Ile Single submitter ⚠
- p.Lys190Arg Single submitter ⚠
- p.Lys310Glu Single submitter ⚠
- p.Lys323Arg Single submitter ⚠
- p.Lys323Glu Single submitter ⚠
- p.Lys34Arg Single submitter ⚠
- p.Met246Val Single submitter ⚠
- p.Met290Ile Single submitter ⚠
- p.Met290Val Single submitter ⚠
- p.Pro129Leu Single submitter ⚠
- p.Pro18Thr Single submitter ⚠
- p.Pro260Thr Single submitter ⚠
- p.Pro289Arg Single submitter ⚠
- p.Pro293Arg Single submitter ⚠
- p.Pro322Arg Single submitter ⚠
- p.Pro349Arg Single submitter ⚠
- p.Ser215Cys Single submitter ⚠
- p.Ser284Leu Single submitter ⚠
- p.Ser287Pro Single submitter ⚠
- p.Ser345Asn Single submitter ⚠
- p.Ser347Pro Single submitter ⚠
- p.Ser402Pro Single submitter
- p.Ser406Cys Single submitter ⚠
- p.Ser425Phe Single submitter ⚠
- p.Ser86Phe Single submitter ⚠
- p.Thr193Met Single submitter ⚠
- p.Thr240Ile Single submitter ⚠
- p.Thr267Ile Single submitter ⚠
- p.Thr350Ile Single submitter ⚠
- p.Thr97Arg Single submitter ⚠
- p.Val229Leu Single submitter ⚠