ELOC — 5 ClinVar variants
All ClinVar germline ELOC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 5 flagged for review →
5 Uncertain significance
Full ELOC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 5
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 1
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 4
The independent predictors disagree with each other — read with care.
All ELOC variants
Uncertain significance 5
- p.Ala96Gly Single submitter ⚠
- p.Glu4Lys Single submitter ⚠
- p.Ile22Leu Single submitter ⚠
- p.Leu21Val Single submitter ⚠
- p.Met75Val Single submitter ⚠